Nanoscale metal–organic frameworks coated with poly(vinyl alcohol) for ratiometric peroxynitrite sensing through FRET

Ding, Zhaoyang; Tan, Jiajia; Feng, Gang; Yuan, Zhen; Wu, Changfeng; Zhang, Xuanjun

doi:10.1039/c7sc01077j

Cited by 58 publications

(24 citation statements)

References 47 publications

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“…It was revealed that loading molecules with strong ICT into pores of MOF or linking onto MOF surface could enhance fluorescence because of the change of the polarity of the local environment. 41−43 In this nanoprobe system, as expected, efficient energy transfer from the NMOF to the molecule BPP was observed after a small amount of BPP was coated onto the surface of the NMOF. Upon reacting with ONOO – , BPP detached from NMOF and the FRET between them was destroyed, which led to the recovery of NMOF fluorescence and the fading of the BPP fluorescence.…”

Section: Resultssupporting

confidence: 80%

Energy-Transfer Metal–Organic Nanoprobe for Ratiometric Sensing with Dual Response to Peroxynitrite and Hypochlorite

et al. 2018

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An energy-transfer metal–organic nanoprobe is designed for ratiometric sensing with dual response to both peroxynitrite (ONOO – ) and hypochlorite (ClO – ). Here, a nanoscale metal–organic framework (NMOF) acts as the energy donor and molecular probe as the acceptor to construct a Förster resonance energy transfer (FRET) nanosystem. Biocompatible dextran conveniently binds to the NMOF surface through multiple weak coordination interactions to improve water dispersibility and cell uptake. Dextran can also coordinate with the molecular probe with arylboronic acid group, which enables the convenient grafting of molecular probes to the NMOF surface to construct energy-transfer nanoprobes. Because of efficient FRET, the bright blue fluorescence of NMOF is quenched, whereas red emission from the acceptor is enhanced. Upon reacting with ONOO – , the probe departs from NMOF and the fluorescence of NMOF is recovered because of the interruption of FRET. When reacting with ClO – , the phenothiazine moiety in the molecular probe is oxidized into phenothiazine-5-oxide, which leads to more efficient energy transfer and the fluorescence shifts from red to orange. The nanoprobes are also successfully applied to the detection of ONOO – and ClO – in living cells.

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Section: Resultssupporting

confidence: 80%

Energy-Transfer Metal–Organic Nanoprobe for Ratiometric Sensing with Dual Response to Peroxynitrite and Hypochlorite

et al. 2018

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“…Nanostructured probes based on different material backbones have been developed for ONOO − . Zhang and co‐workers constructed a nanoscale metal‐organic framework (NMOF), which was coated with two kinds of poly(vinyl alcohol) (PVA). A fluorophore modified with a boronic acid group was attached to the surface of the NMOF through binding to the exposed diols of PVA.…”

Section: Fluorescent Probes For the Detection Of Ros‐related Diseasesmentioning

confidence: 99%

Section: Fluorescent Probes For the Detection Of Ros‐related Diseasesmentioning

confidence: 99%

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

et al. 2019

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Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence‐based strategies, many small‐molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence‐based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

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“…Ratiometric imaging depends on recording fluorescence intensities at two wavelengths simultaneously and calculating the ratio between the two intensities. This technique significantly reduces the effects of environmental changes around the sensor and consequently results in enhanced sensitivity [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

A Coumarin-Benzothiazole Derivative as a FRET-Based Chemosensor of Adenosine 5′-Triphosphate

et al. 2019

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A coumarin-benzothiazole ratiometric probe of ATP was designed and synthesized. The probe is based on incorporation of benzothiazole scaffold as a donor and coumarin nucleus as an acceptor in a single Förster resonance energy transfer/fluorescence resonance energy transfer (FRET) sensing platform. The sensor can detect ATP in aqueous solution with high selectivity over other nucleotide polyphosphate (NPP) anions. Binding of ATP to the sensor results in modulation of FRET efficiency between the donor and the acceptor which afforded a linear relationship between FRET signal and ATP (0.1–10 μM). A limit of detection (LOD) of 94.5 nM was quantified for FRET sensing of ATP by the probe. In addition, Job plot analysis revealed 1:1 binding interaction between the probe and ATP. The FRET probe was successfully utilized in monitoring ATP hydrolysis by apyrase in aqueous solution.

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Nanoscale metal–organic frameworks coated with poly(vinyl alcohol) for ratiometric peroxynitrite sensing through FRET

Abstract: This work describes a facile yet powerful approach to energy-transfer NMOF (nanoscale metal–organic framework) fabrication for ratiometric peroxynitrite (ONOO–) sensing.

Cited by 58 publications

References 47 publications

Energy-Transfer Metal–Organic Nanoprobe for Ratiometric Sensing with Dual Response to Peroxynitrite and Hypochlorite

Energy-Transfer Metal–Organic Nanoprobe for Ratiometric Sensing with Dual Response to Peroxynitrite and Hypochlorite

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

A Coumarin-Benzothiazole Derivative as a FRET-Based Chemosensor of Adenosine 5′-Triphosphate

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