Nanoscale Metal–Organic Framework Hierarchically Combines High-Z Components for Multifarious Radio-Enhancement

Lan, Guangxu; Ni, Kaiyuan; Veroneau, Samuel S.; Luo, Taokun; You, Eric; Lin, Wenbin

doi:10.1021/jacs.9b03029

Cited by 75 publications

(70 citation statements)

References 31 publications

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“…[2][3][4][5][6] Apart from the bulk phase, nanoscale MOFs (NMOFs) have attracted support from researchers 7,8 for their designable multiple elements, porous architecture and good biocompatibility; this is especially true for biomaterials scientists in recent years. [9][10][11][12] For example, a series of studies on NMOFs for enhancing photodynamic therapy (PDT), radiotherapy, chemotherapy and immunotherapy were performed by Lin's group, [13][14][15][16] and various high-efficiency NMOFs were designed, synthesized and applied for cancer treatments. Wang et al reported a multifunctional Mn-Cobased NMOF that can catalyse tumour endogenous H 2 O 2 decomposition for O 2 generation to achieve negative MRIguided PDT.…”

Section: Introductionmentioning

confidence: 99%

“…25 As a high-Z element, Hf, with high X-ray attenuation, can be used as an efficient X-ray CT contrast agent 26 and RT. 16 Porphyrins and their derivatives have good photophysical properties and have been widely used as photosensitizers for PDT, PTT and PAI. 27 For tumour targeting, folic acid (FA) was directly conjugated to the Hf 6 cluster with the carboxylate end of the folate by coordination.…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy

Bao¹,

Zu²,

Wang³

et al. 2020

IJN

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Background: Recent studies have validated and confirmed the great potential of nanoscale metal-organic framework (NMOF) in the biomedical field, especially in improving the efficiency of cancer diagnosis and therapy. However, most previous studies only utilized either the metal cluster or the organic ligand of the NMOF for cancer treatments and merely reported limited theranostic functions, which may not be optimized. As a highly designable and easily functionalized material, prospective rational design offers a powerful way to extract the maximum benefit from NMOF for cancer theranostic applications. Materials and Methods: A NMOF based on hafnium (Hf) cluster and Mn(III)-porphyrin ligand was rational designed and synthesized as a high-performance multifunctional theranostic agent. The folic acid (FA) was modified on the NMOF surface to enhance the cancer targeting efficacy. The proposed "all-in-one" FA-Hf-Mn-NMOF (fHMNM) was characterized and identified using various analytical techniques. Then, in vitro and in vivo studies were performed to further explore the effects of fHMNM both as the magnetic resonance imaging (MRI)/computed tomography (CT)/photoacoustic imaging (PAI) contrast agent and as the photothermal therapy (PTT)/radiotherapy (RT) agent. Results: A tumour targeting multifunctional fHMNM was successfully synthesized with high performance for MRI/CT/PAI enhancements and image-guided PTT/RT synergistic therapy properties. Compared with the current clinical CT and MR contrast agents, the X-ray attenuation and T 1 relaxation rate of this integrated nanosystem increased 1.7-fold and 3-5-fold, respectively. More importantly, the catalase-like Mn(III)-porphyrin ligand can decompose H 2 O 2 into O 2 in tumour microenvironments to improve the synergistic treatment efficiency of PTT and RT. Significant tumour growth inhibition was achieved in mouse cancer models without obvious damage to the other organs. Conclusion: This work highlights the potential of fHMNM as an easily designable material for biomedical applications, could be an effective tool for in vivo detection and subsequent treatment of tumour.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy

Bao¹,

Zu²,

Wang³

et al. 2020

IJN

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“…In vivo study demonstrated that NMOF-enabled mitochondria-targeted RT-RDT led to obvious regression of MC38/ CT26 xenograft tumors. More recently, Lan et al 43 synthesized a multifarious radioenhancer by integrating three high-Z components (Hf 12 , DBB-Ir and W 18 ) into one NMOF. Upon X-ray irradiation, W 18 @Hf 12 -DBB-Ir showed superb anticancer efficacy on two murine colorectal adenocarcinoma models.…”

Section: Implication Of Nmofs In Rtmentioning

confidence: 99%

Recent Progress of Nanoscale Metal-Organic Frameworks in Cancer Theranostics and the Challenges of Their Clinical Application

Sun¹,

Li²,

Tang³

et al. 2020

IJN

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The growing incidence of cancer raises an urgent need to develop effective diagnostic and therapeutic strategies. With the rapid development of nanomedicine, nanoscale metal-organic frameworks (NMOFs) presented promising potential in various biomedical applications in the last 2 decades, especially in cancer theranostics. Due to the unique features of NMOFs, including structural diversities, enormous porosity, multifunctionality and biocompatibility, they have been widely used to deliver imaging contrast agents and therapeutic drugs. Moreover, multiple types of contrast agents, anti-cancer drugs and targeting ligands could be co-delivered through one single NMOF to enable combination therapy. Co-delivering system using NMOFs helped to avoid multidrug resistance, to reduce adverse effects, to achieve imaging-guided precise therapy and to enhance anti-cancer efficacy. This review summarized the recent research advances on the application of NMOFs in biomedical imaging and cancer treatments in the last few years. The current challenges that impeding their translation to clinical practices and the perspectives for their future applications were also highlighted and discussed.

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“…Using a different approach, Lan and co‐workers prepared a metal–organic framework (MOF) constituted by Hf 12 building units and [Ir(bpy) 2 (ppy)] + (bpy = 2,2'‐bipyridine, ppy = 2‐phenylpyridine) derived dicarboxylate ligands (DBB‐Ir) forming cationic Hf 12 ‐DBB‐Ir, which was then loaded with the Wells–Dawson anion [P 2 W 18 O 62 ] 6– (W 18 ), see Figure . Without X‐ray irradiation, W 18 @Hf 12 ‐DBB‐Ir exhibited low cytotoxicity in vitro (MC38 and CT26 cells) and no systemic toxicity in vivo (MC38‐ and CT26‐tumour‐bearing mice).…”

Section: Polyoxometalate Composites As Radiosensitisersmentioning

confidence: 99%

“…It is also schematised the production of three distinct ROS, namely · OH, 1 O 2 , and O 2 – , by each one of the MOF subunits. Reprinted with permission from ref . Copyright 2019 American Chemical Society.…”

Section: Polyoxometalate Composites As Radiosensitisersmentioning

confidence: 99%

Polyoxometalate Composites in Cancer Therapy and Diagnostics

et al. 2020

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Polyoxometalates (POMs) are metal‐oxide inorganic clusters, mostly anionic, where the metal is usually a transition metal (such as V, W, or Mo). Owing to their great variety of structures and large range of molecular dimensions, POMs have attracted considerable attention over the years. The high solubility in water together with the extent of their redox chemistry make POMs and their composites very versatile materials that find many applications in the biomedical field such as drug delivery systems or anti‐viral and anti‐tumoural agents. While the antitumoural activity of POMs and their derivatives is well documented, their application in emergent cancer therapies has not been addressed. This review presents the application of POM‐based composites as photothermal agents, radiosensitisers, and biosensors. The latest advances in the design of novel POM nanocomposites for cancer theranostics are also highlighted.

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Nanoscale Metal–Organic Framework Hierarchically Combines High-Z Components for Multifarious Radio-Enhancement

Cited by 75 publications

References 31 publications

<p>Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy</p>

<p>Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy</p>

<p>Recent Progress of Nanoscale Metal-Organic Frameworks in Cancer Theranostics and the Challenges of Their Clinical Application</p>

Polyoxometalate Composites in Cancer Therapy and Diagnostics

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