Nanoscale Glutathione-Functionalized Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Loaded with Metformin for the Treatment of Spinal Cord Injury
Zhiru Zou,
Shan Wen,
Qi Yu
et al.
Abstract:Spinal cord injury (SCI) is a central nervous system
disease with
a high disability. Immune activation of microglia cells can be induced,
and the activated microglia cells are mainly divided into two different
subtypes, namely, proinflammatory phenotype (M1) and anti-inflammatory
phenotype (M2). Regulating the transformation of microglial subtypes
is the key to alleviating inflammation. However, because of the blood–spinal
cord barrier (BSCB), most drugs cannot reach the target site and give
a full effect. The… Show more
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