Nanoscale Delivery Systems for Combination Chemotherapy

Liboiron, Barry D.; Tardi, Paul; Harasym, BS Troy O.; Mayer, BS Lawrence D.

doi:10.1002/9783527634057.ch31

Cited by 2 publications

(1 citation statement)

References 92 publications

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“…Scientists and clinicians are making concerted efforts to develop pharmacological and immunological interventions for multiple targets, which are efficient, cost effective and could potentially increase the life span of patients with advanced stage cancers. Some clinical studies on pediatric leukemia showed that the efficacy of monotherapies was remarkably enhanced when another drug was administered together during the treatment ( 10 ). Currently, biologically active molecules and adoptive cell therapies are considered to be the most advanced areas of research in the development of potential therapeutics for cancer treatments.…”

Section: Introductionmentioning

confidence: 99%

Biologically Active α-Amino Amide Analogs and γδ T Cells—A Unique Anticancer Approach for Leukemia

et al. 2021

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Advanced stage cancers are aggressive and difficult to treat with mono-therapeutics, substantially decreasing patient survival rates. Hence, there is an urgent need to develop unique therapeutic approaches to treat cancer with superior potency and efficacy. This study investigates a new approach to develop a potent combinational therapy to treat advanced stage leukemia. Biologically active α-amino amide analogs (RS)-N-(2-(cyclohexylamino)-2-oxo-1-phenylethyl)-N-phenylpropiolamide (α-AAA-A) and (RS)-N-(2-(cyclohexylamino)-2-oxo-1-phenylethyl)-N-phenylbut2-enamide (α-AAA-B) were synthesized using linear Ugi multicomponent reaction. Cytotoxicities and IC50 values of α-AAA-A and α-AAA-B against leukemia cancer cell lines (HL-60 and K562) were analyzed though MTT assay. Cytotoxic assay analyzed percent killing of leukemia cell lines due to the effect of γδ T cells alone or in combination with α-AAA-A or α-AAA-B. Synthesized biologically active molecule α-AAA-A exhibited increased cytotoxicity of HL-60 (54%) and K562 (44%) compared with α-AAA-B (44% and 36% respectively). Similarly, α-AAA-A showed low IC50 values for HL-60 (1.61 ± 0.11 μM) and K562 (3.01 ± 0.14 μM) compared to α-AAA-B (3.12 ± 0.15 μM and 6.21 ± 0.17 μM respectively). Additive effect of amide analogs and γδ T cells showed significantly high leukemia cancer cell killing as compared to γδ T cells alone. A unique combinational therapy with γδ T cells and biologically active anti-cancer molecules (α-AAA-A/B), concomitantly may be a promising cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Biologically Active α-Amino Amide Analogs and γδ T Cells—A Unique Anticancer Approach for Leukemia

et al. 2021

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Nanoscale Particulate Systems for Multidrug Delivery: Towards Improved Combination Chemotherapy

Liboiron

Mayer

2014

Ther. Deliv.

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While combination chemotherapy has led to measurable improvements in cancer treatment outcomes, its full potential remains to be realized. Nanoscale particles such as liposomes, nanoparticles and polymer micelles have been shown to increase delivery to the tumor site while bypassing many drug resistance mechanisms that limit the effectiveness of conventional therapies. Recent efforts in drug delivery have focused on coordinated, controlled delivery of multiple anticancer agents encapsulated within a single particle system. In this review, we analyze recent progress made in multidrug delivery in three main areas of interest: co-delivery of antineoplastic agents with drug sensitizers, sequential delivery via temporal release particles and simultaneous delivery of multiple agents. Future directions of the field, in light of recent advances with molecularly targeted agents, are suggested and discussed.

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Nanoscale Delivery Systems for Combination Chemotherapy

Cited by 2 publications

References 92 publications

Biologically Active α-Amino Amide Analogs and γδ T Cells—A Unique Anticancer Approach for Leukemia

Biologically Active α-Amino Amide Analogs and γδ T Cells—A Unique Anticancer Approach for Leukemia

Nanoscale Particulate Systems for Multidrug Delivery: Towards Improved Combination Chemotherapy

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