Nanoscale covalent organic frameworks as smart carriers for drug delivery

Bai, Linyi; Phua, Soo Zeng Fiona; Lim, Wei Qi; Jana, Avijit; Luo, Zhong; Tham, Huijun Phoebe; Zhao, Lingzhi; Gao, Qiang; Zhao, Yanli

doi:10.1039/c6cc00853d

Cited by 391 publications

(283 citation statements)

References 30 publications

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“…Recently, these porous frameworks open up a new avenue for exciting opportunities in biomedical and pharmaceutical fields. Especially, the imine‐linked COFs with enhanced hydrolytic stability as drug carrier have been widely investigated and demonstrated various advantages . For example, the combination of high surface area, tunable pore structure, and π–π stacking interactions endows COFs with high loading capacity and minimized drug leakage.…”

Section: Methodsmentioning

confidence: 99%

“…Due to the unique and attractive features, various COFs have exhibited great potential to serve as a promising platform for drug delivery. Especially, the imine‐linked COFs based on Schiff‐base chemistry possessed a high hydrolytic stability in aqueous solutions over a wide pH range and provided some distinctive advantages for biomedical and pharmaceutical applications . The disulfide bond containing COFs (SS‐COFs) were prepared by use of an acetic‐acid‐catalyzed Schiff‐base between commercially available DDS and BTA as building blocks.…”

Section: Methodsmentioning

confidence: 99%

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Facile Fabrication of Redox‐Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin

Liu

Yang

Guo

et al. 2020

Macromol. Rapid Commun.

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Covalent organic frameworks (COFs) as drug delivery systems have shown great promise, but their pharmaceutical applications are often limited by complex building blocks, tedious preparations, irregular shape, and uncontrolled drug release within target cells. Herein, a facile strategy is developed to prepare PEGylated redox‐responsive nanoscale COFs (denoted F68@SS‐COFs) for efficiently loading and delivering doxorubicin (DOX) by use of FDA‐approved Pluronic F68 and commercially available building blocks. The obtained F68@SS‐COFs with controlled size, high stability, and good biocompatibility can not only achieve a very high DOX‐loading content (about 21%) and very low premature leakage at physiological condition but can also rapidly respond to the tumor intracellular microenvironment and efficiently release DOX to kill tumor cells. Considering the readily available raw materials, simple preparation process, and desirable redox‐responsiveness, the strategy provided here opens up a promising avenue to develop well‐defined COFs‐based nanomedicines for cancer therapy.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Facile Fabrication of Redox‐Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin

Liu

Yang

Guo

et al. 2020

Macromol. Rapid Commun.

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show abstract

“…They have also found to be of great potential for utilities in water treatment, 10 energy storage, 11 gas adsorption 12 and drug delivery. 13 Porous carbon possesses multifaceted advantages for CCS such as high physicochemical stabilities, good moisture stability, light weight, low cost and ease of regeneration.…”

Section: Introductionmentioning

confidence: 99%

Facile Carbonization of Microporous Organic Polymers into Hierarchically Porous Carbons Targeted for Effective CO₂ Uptake at Low Pressures

Zhu

et al. 2016

ACS Appl. Mater. Interfaces

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The advent of microporous organic polymers (MOPs) has delivered great potential in gas storage and separation (CCS). However, the presence of only micropores in these polymers often imposes diffusion limitations, which has resulted in the low utilization of MOPs in CCS. Herein, facile chemical activation of the single microporous organic polymers (MOPs) resulted in a series of hierarchically porous carbons with hierarchically meso-microporous structures and high CO2 uptake capacities at low pressures. The MOPs precursors (termed as MOP-7-10) with a simple narrow micropore structure obtained in this work possess moderate apparent BET surface areas ranging from 479 to 819 m(2) g(-1). By comparing different activating agents for the carbonization of these MOPs matrials, we found the optimized carbon matrials MOPs-C activated by KOH show unique hierarchically porous structures with a significant expansion of dominant pore size from micropores to mesopores, whereas their microporosity is also significantly improved, which was evidenced by a significant increase in the micropore volume (from 0.27 to 0.68 cm(3) g(-1)). This maybe related to the collapse and the structural rearrangement of the polymer farmeworks resulted from the activation of the activating agent KOH at high temperature. The as-made hierarchically porous carbons MOPs-C show an obvious increase in the BET surface area (from 819 to 1824 m(2) g(-1)). And the unique hierarchically porous structures of MOPs-C significantly contributed to the enhancement of the CO2 capture capacities, which are up to 214 mg g(-1) (at 273 K and 1 bar) and 52 mg g(-1) (at 273 K and 0.15 bar), superior to those of the most known MOPs and porous carbons. The high physicochemical stabilities and appropriate isosteric adsorption heats as well as high CO2/N2 ideal selectivities endow these hierarchically porous carbon materials great potential in gas sorption and separation.

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“…The syntheses of COFs have attracted significant interest due to their outstanding properties such as low mass density, controllable pore structure, inherent porosity, large specific surface area, and high stability . These properties make COFs great potential such as in gas storage , catalysis , proton and ion conduction , chemical sensing and drug delivery .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a hydrazone‐linked covalent organic framework‐bound capillary column for gas chromatography separation

Huang

Lan

Yan

et al. 2019

Separation Science Plus

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Covalent organic frameworks are a new class of crystalline porous materials that have various potential applications. However, utilization of covalent organic frameworks as new stationary phases for gas chromatography separation has been less explored. In this work, a hydrazone‐linked chiral covalent organic framework has been covalently bonded onto the inner surface of fused silica capillary. The fabricated hydrazone‐linked covalent organic framework‐bound capillary column displays a moderate polarity nature and exhibits relatively high resolution performances for separation of linear alkanes and alcohols, as well as aromatic positional isomers including xylene, nitrotoluene, chloronitrobenzene, benzenediol, and naphthol isomers. The present study reveals that the hydrazone‐linked covalent organic framework‐bound capillary column is quite promising for the gas chromatography separation of aromatic positional isomers.

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Nanoscale covalent organic frameworks as smart carriers for drug delivery

Abstract: Two porous covalent organic frameworks (COFs) with good biocompatibility were employed as drug nanocarriers, where three different drugs were loaded for subsequent drug release in vitro. The present work demonstrates that COFs are applicable in drug delivery for therapeutic applications.

Cited by 391 publications

References 30 publications

Facile Fabrication of Redox‐Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin

Facile Fabrication of Redox‐Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin

Facile Carbonization of Microporous Organic Polymers into Hierarchically Porous Carbons Targeted for Effective CO₂ Uptake at Low Pressures

Fabrication of a hydrazone‐linked covalent organic framework‐bound capillary column for gas chromatography separation

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Nanoscale covalent organic frameworks as smart carriers for drug delivery

Abstract: Two porous covalent organic frameworks (COFs) with good biocompatibility were employed as drug nanocarriers, where three different drugs were loaded for subsequent drug release in vitro. The present work demonstrates that COFs are applicable in drug delivery for therapeutic applications.

Cited by 391 publications

References 30 publications

Facile Fabrication of Redox‐Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin

Facile Fabrication of Redox‐Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin

Facile Carbonization of Microporous Organic Polymers into Hierarchically Porous Carbons Targeted for Effective CO2 Uptake at Low Pressures

Fabrication of a hydrazone‐linked covalent organic framework‐bound capillary column for gas chromatography separation

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Product

Resources

About

Facile Carbonization of Microporous Organic Polymers into Hierarchically Porous Carbons Targeted for Effective CO₂ Uptake at Low Pressures