Nanoscale Composite Lignin Colloids with Tunable Visible Colors Used for Anti-UV Cosmetics

Bai, Yating; Li, Xinke; Wang, Xing; Wang, Xinru; Yang, Xujie; Xin, Hanwen; Sun, Dayin; Zhou, Jinghui; Chai, Minghao

doi:10.1021/acs.langmuir.3c02764

Cited by 3 publications

(1 citation statement)

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“…Most lignin is either incinerated for energy generation or discharged, resulting in a considerably low utilization rate for high-value applications. , Nevertheless, lignin, as a polyphenolic polymer, exhibits biocompatibility, biodegradability, and low toxicity. Its benzene ring, hydroxyl group, and conjugated structure contribute to its antioxidant and UV-absorbing properties . Industrial lignin, in particular, may possess antimicrobial properties and probiotic effects, which can be beneficial for intestinal health .…”

Section: Introductionmentioning

confidence: 99%

Lipase-Responsive Lignin Composite Nanoparticles for the Delivery of Insoluble Bioactives

Bai,

Liu,

et al. 2024

Langmuir

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Low solubility and chemical instability are the main problems with insoluble bioactives. Lignin, with its exceptional biological properties and amphiphilicity, holds promise as a delivery system material. In this study, glycerol esters were incorporated into alkali lignin (AL) through ether and ester bonds, resulting in the successful synthesis of three hydrophobically modified alkali lignins (AL-OA, AL-OGL, and AL-SAN-OGL). Subsequently, lignin composite nanoparticles (LNPs@BC) encapsulating β-carotene were prepared using antisolvent and sonication techniques. The encapsulation rates were determined to be 37.69 ± 2.21%, 84.01 ± 5.55%, 83.82 ± 5.23%, and 83.11 ± 5.85% for LNP@BC-1, LNP@BC-2, LNP@BC-3, and LNP@BC-4, respectively, with AL, AL-OA, AL-OGL, and AL-SAN-OGL serving as the wall materials under optimized preparation conditions. The antioxidant properties and UV-absorbing capacity of the four lignins were characterized, demonstrating their efficacy in enhancing the oxygen and photostability of β-carotene. Following 6 h of UV irradiation, LNP@BC-4 exhibited a retention rate of 83.03 ± 2.85% for β-carotene, while storage under light-protected conditions at 25 °C for 7 days retained 73.33 ± 7.62% of β-carotene. Furthermore, the encapsulated β-carotene demonstrated enhanced thermal and storage stability. In vitro release experiments revealed superior stability of LNPs@BC in simulated gastric fluid (SGF), with β-carotene retention exceeding 77% in both LNP@BC-3 and LNP@BC-4. LNP@BC-4 exhibited the highest bioaccessibility in simulated intestinal fluid (SIF) at 46.96 ± 0.80%, that LNP@BC-1 only achieved 10.87 ± 0.90%. The enzymatic responsiveness of AL-OGL and AL-SAN-OGL was confirmed. Moreover, LNPs@BC exhibited no cytotoxicity toward L929 cells and demonstrated excellent hemocompatibility. In summary, this study introduces a novel enzyme-responsive modified lignin that has promising applications in the fields of food, biomedicine, and animal feed.

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