Nanoscale celecoxib prodrugs: As efficient anti-inflammatory principles

Saleem, Rudaba; Rehman, Mujeeb-ur; Hussain, Saadat; Arif, Aqsa; Malik, Hira Noor; Naqvi, Farwa; Jabeen, Almas

doi:10.1016/j.jddst.2023.105089

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…A prodrug of celecoxib (celecoxib-butyryl) was shown to have greater relative bioavailability than standard celecoxib when taken orally [172]. Similarly, nano-sized celecoxib prodrugs were shown to have in vitro anti-inflammatory activity by inhibiting TNF-α synthesis in a lipopolysaccharide-activated cell line [173]. However, these formulations were found to be less effective at decreasing swelling than standard celecoxib using a mouse collageninduced arthritis model due to slow release from the prodrug.…”

Section: Prodrugsmentioning

confidence: 99%

Strategies to Improve the Transdermal Delivery of Poorly Water-Soluble Non-Steroidal Anti-Inflammatory Drugs

Balmanno,

Falconer,

Ravuri

et al. 2024

Pharmaceutics

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The transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has the potential to overcome some of the major disadvantages relating to oral NSAID usage, such as gastrointestinal adverse events and compliance. However, the poor solubility of many of the newer NSAIDs creates challenges in incorporating the drugs into formulations suitable for application to skin and may limit transdermal permeation, particularly if the goal is therapeutic systemic drug concentrations. This review is an overview of the various strategies used to increase the solubility of poorly soluble NSAIDs and enhance their permeation through skin, such as the modification of the vehicle, the modification of or bypassing the barrier function of the skin, and using advanced nano-sized formulations. Furthermore, the simple yet highly versatile microemulsion system has been found to be a cost-effective and highly successful technology to deliver poorly water-soluble NSAIDs.

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Section: Prodrugsmentioning

confidence: 99%