Nanoscale Cage-like Structures Derived from Polyisoprene-Containing Shell Cross-linked Nanoparticle Templates

Turner, Jeffrey L.; Wooley, Karen L.

doi:10.1021/nl0497981

Cited by 77 publications

(62 citation statements)

References 47 publications

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“…Hence, they can be also utilized for the controlled formation of hollow nanostructures. [108][109][110] The general fabrication procedure is as follows: i) synthesis of block copolymer composed of a crosslinkable block and a degradable block; ii) micellization; iii) crosslinking of the shell block; iv) removal of the core block by chemical degradation. Wooley's group has studied the fabrication of hollow nanospheres by ozonolysis of shell-crosslinked micelles consisting of a series of block copolymers.…”

Section: Polymer Nanostructuresmentioning

confidence: 99%

“…Poly(isoprene-b-acrylic acid) (PI-b-PAA) diblock copolymers formed micelles with a PI core and a PAA shell in an aqueous solution. 108 The PAA shell was crosslinked with a diamino crosslinker, 2,2'-(ethylenedioxy)bis(ethylamine), and the PI core could be removed by ozonolytic degradation. Similarly, poly (ε-caprolactone-b-acrylic acid) (PCL-b-PAA) diblock copolymers formed micelles with a PCL core and a PAA shell in an aqueous solution.…”

Section: Polymer Nanostructuresmentioning

confidence: 99%

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Versatile strategies for fabricating polymer nanomaterials with controlled size and morphology

et al. 2008

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The development of reliable synthetic routes to polymer nanomaterials with well-defined size and morphology is a critical research topic in contemporary materials science. The ability to generate nanometer-sized polymer materials can offer unprecedented, interesting insights into the physical and chemical properties of the corresponding materials. In addition, control over shape and geometry of polymer nanoparticles affords versatile polymer nanostructures, encompassing nanospheres, core-shell nanoparticles, hollow nanoparticles, nanorods/ fibers, nanotubes, and nanoporous materials. This review summarizes a diverse range of synthetic methods (broadly, hard template synthesis, soft template synthesis, and template-free synthesis) for fabricating polymer nanomaterials. The basic concepts and significant issues with respect to the synthetic strategies and tools are briefly introduced, and the examples of some of the outstanding research are highlighted. Our aim is to present a comprehensive review of research activities that concentrate on fabrication of various kinds of polymer nanoparticles.

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Section: Polymer Nanostructuresmentioning

confidence: 99%

Section: Polymer Nanostructuresmentioning

confidence: 99%

Versatile strategies for fabricating polymer nanomaterials with controlled size and morphology

et al. 2008

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“…Core-polymerization was employed to stabilize micelles of heterotelechelic amphiphilic block copolymers containing polymerizable groups at the ends of hydrophobic blocks [234]. Wooley et al have developed cage-like nanostructures on the base of polymeric micelles with hydrophobic core and cross-linked anionic shell [155,235,236]. In addition micelles with cross-linked ionic cores were prepared by self-assembly of ionic blocks of double hydrophilic block copolymers with a condensing agent, followed by chemical cross-linking of ionic blocks [153].…”

Section: Polymeric Micellesmentioning

confidence: 99%

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

Kabanov

Gendelman

2007

Progress in Polymer Science

234

138

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Neurodegenerative and infectious disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population's age. Alzheimer's disease alone currently affects 4.5 million Americans, and more than $100 billion is spent per year on medical and institutional care for affected people. Such numbers will double in the ensuing decades. Currently disease diagnosis for all disorders is made, in large measure, on clinical grounds as laboratory and neuroimaging tests confirm what is seen by more routine examination. Achieving early diagnosis would enable improved disease outcomes. Drugs, vaccines or regenerative proteins present "real" possibilities for positively affecting disease outcomes, but are limited in that their entry into the brain is commonly restricted across the blood-brain barrier. This review highlights how these obstacles can be overcome by polymer science and nanotechnology. Such approaches may improve diagnostic and therapeutic outcomes. New developments in polymer science coupled with cell-based delivery strategies support the notion that diseases that now have limited therapeutic options can show improved outcomes by advances in nanomedicine.

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“…There are many reports on pH-sensitive polymeric nanospheres and hollow spheres in the literatures [6,7,[18][19][20][21][22][23][24][25][26]. Wooley et al [6,18] reported a sophisticated procedure containing successive steps: micellization of a block copolymer in the selective solvent forming a degradable core and cross-linkable shell, crosslinking the shell and chemical degradation of the core.…”

Section: Ph-sensitive Polymeric Nanospheres and Hollow Spheresmentioning

confidence: 99%

“…Wooley et al [6,18] reported a sophisticated procedure containing successive steps: micellization of a block copolymer in the selective solvent forming a degradable core and cross-linkable shell, crosslinking the shell and chemical degradation of the core. Thus, for example, pH-sensitive hollow spheres (or nanocages) of crosslinked poly(acrylic acid) (PAA) were obtained thereby.…”

Section: Ph-sensitive Polymeric Nanospheres and Hollow Spheresmentioning

confidence: 99%

New approaches to stimuli-responsive polymeric micelles and hollow spheres

Jiang

Zhang

2006

Front. Chem. China

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This article briefly describes some new approaches to stimuli-sensitive polymeric micelles and hollow spheres, which were developed in the authors' laboratory in recent years. (1) Self-assembly of component polymers to non-covalently connected micelles (NCCM) driven by specific interactions. For example, in water, PCL and PAA formed core-shell nanospheres due to interpolymer hydrogen bonding. After crosslinking the PAA shell and removing the PCL core, "nanocages" made of PAA network were obtained. This hollow structure shows perfect reversible size-pH dependence.(2) Simultaneous in-situ polymerization of monomers and self-assembly of the polymers. In this approach, PNIPAM network was formed by radical polymerization covering PCL particles. Hollow spheres of PNIPAM network were then obtained by biodegradation of the PCL core. Both the core-shell spheres and hollow spheres show reversible size dependence on temperature change because of the phase transition of PNIPAM around 32°C. (3) Complexation-induced micellization and transition between the micelles and hollow spheres. Graft copolymers of hydroxylethyl cellulose (HEC) and PAA were prepared by free radical polymerization. The copolymers showed pH dependent micellization, i.e., micelles formed when pH of the graft copolymer solution decreased to around 3. The micellar structure could be locked by crosslinking the PAA grafts. The resultant cross-linked micelles undergo pH-dependent transition between the micelles and hollow spheres, which accompanies a remarkable particle size change. Both the micellization and the structure transition were found to be reversible and associated with H-bonding complexation between the main chain and grafts.Keywords micelle, hollow sphere, hydrogen bonding, self-assembly, stimuli-sensitivityIn recent years, efforts in our group have been made to develop new routes for polymer micellization. Based on our long-term research on interpolymer complexation [1], we succeeded in developing a series of routes for macromolecular assembly [2]. Differing from the traditional self-assembly of block copolymers in selective solvents, we obtained a series of new type polymeric micelles via macromolecular assembly driven by interpolymer hydrogen bonding complexation, in which homopolymer, random copolymer, graft copolymer and oligomer were used as building blocks. As the new micelles have no covalent bond connecting the core and shell, they are called non-covalently connected micelles (NCCM). The procedure is also called "block-copolymer-free" route for polymer micellization. In this paper, we briefly summarize a part of this work with emphasis on the new routes to stimuli-sensitive NCCMs and hollow spheres, and the structure and properties of the obtained assemblies.Polymeric nanospheres or micelles (polymeric nanospheres, for simplification) with stable core-shell structures and hollow spheres with inner cavity structures in nano or sub-micro scales have many applications in biomedicine, micro-reactors, environmental protection and others. For exa...

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Nanoscale Cage-like Structures Derived from Polyisoprene-Containing Shell Cross-linked Nanoparticle Templates

Cited by 77 publications

References 47 publications

Versatile strategies for fabricating polymer nanomaterials with controlled size and morphology

Versatile strategies for fabricating polymer nanomaterials with controlled size and morphology

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

New approaches to stimuli-responsive polymeric micelles and hollow spheres

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