Nanoscale Biodegradable Organic–Inorganic Hybrids for Efficient Cell Penetration and Drug Delivery

Hörner, Sebastian; Knauer, Sascha; Uth, Christina; Jöst, Marina; Schmidts, Volker; Frauendorf, Holm; Thiele, Christina M.; Avrutina, Olga; Kolmar, Harald

doi:10.1002/anie.201606065

Cited by 17 publications

(10 citation statements)

References 52 publications

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“…The other factor is the well-known high ability of POSS to penetrate cell membranes. 30 Both these properties of POSS-NH 2 $HCl-DOX system appear to interplay and lead to improved activity on co-delivery of POSS and DOX. These results can point to a useful and simple way of improving efficacy of chemotherapy also for other drug-POSS systems, provided they contain functional groups assuring such weak but efficient interactions.…”

Section: Discussionmentioning

confidence: 99%

Reasons for enhanced activity of doxorubicin on co-delivery with octa(3-aminopropyl)silsesquioxane

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Reasons for enhanced activity of doxorubicin on co-delivery with octa(3-aminopropyl)silsesquioxane

et al. 2020

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“…In addition, POSS shows low toxicity and excellent biocompatibility. [ 75,76 ] These combined features have triggered an interest in the application of POSS structures in areas such as bioimaging [ 77–79 ] and nanomedicine. [ 80 ]…”

Section: Applications Of Poss As Photoluminescent Materialsmentioning

confidence: 99%

The Role of Polyhedral Oligomeric Silsesquioxanes in Optical Applications

Tunstall-Garcia

Charles

Evans

2021

Advanced Photonics Research

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The popularity of polyhedral oligomeric silsesquioxanes (POSS) for use in hybrid organic–inorganic materials and devices has grown in the past two decades due to desirable properties such as good thermal stability and biocompatibility, as well as their potential to be functionalized for a wide range of applications, from polymer composites to optoelectronics. Herein, the role of POSS for photonic applications, including sensing, bioimaging, and optoelectronic devices, is summarized. Functionalized POSS building blocks commonly incorporated with luminescent materials are identified, and areas of potential growth within the field are discussed. The addition of POSS to light‐emitting materials is widely shown to prevent aggregation in organic lumophores and inorganic nanocrystals, leading to reduced photoluminescence quenching. The POSS unit is also capable of acting as a passivating agent for nanocrystals and thin films, improving the emission quantum yields of photoluminescent materials and devices. POSS therefore offers the potential to enhance both the functional and photonic properties of cutting‐edge hybrid technologies.

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“…Arginine-rich peptides such as trans-activator of transcription or homeoprotein transcription factors appear in nature and thus are evolutionarily optimized in the presence of biological fluids. Recently, it was demonstrated that cubeoctameric silsesquioxanes 70 with similar positively charged ligands efficiently translocate through cell membranes.…”

Section: A Properties Of the Surrounding Mediamentioning

confidence: 99%

Nanomaterial interactions with biomembranes: Bridging the gap between soft matter models and biological context

et al. 2018

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Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and the alteration of biological function. Nature and humans use different design strategies to create nanomaterials: biological objects have emerged from billions of years of evolution and from adaptation to their environment resulting in high levels of structural complexity; in contrast, synthetic nanomaterials result from minimalistic but controlled design options limited by the authors' current understanding of the biological world. This conceptual mismatch makes it challenging to create synthetic nanomaterials that possess desired functions in biological media. In many biologically relevant applications, nanomaterials must enter the cell interior to perform their functions. An essential transport barrier is the cell-protecting plasma membrane and hence the understanding of its interaction with nanomaterials is a fundamental task in biotechnology. The authors present open questions in the field of nanomaterial interactions with biological membranes, including: how physical mechanisms and molecular forces acting at the nanoscale restrict or inspire design options; which levels of complexity to include next in computational and experimental models to describe how nanomaterials cross barriers via passive or active processes; and how the biological media and protein corona interfere with nanomaterial functionality. In this Perspective, the authors address these questions with the aim of offering guidelines for the development of next-generation nanomaterials that function in biological media.

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Nanoscale Biodegradable Organic–Inorganic Hybrids for Efficient Cell Penetration and Drug Delivery

Cited by 17 publications

References 52 publications

Reasons for enhanced activity of doxorubicin on co-delivery with octa(3-aminopropyl)silsesquioxane

Reasons for enhanced activity of doxorubicin on co-delivery with octa(3-aminopropyl)silsesquioxane

The Role of Polyhedral Oligomeric Silsesquioxanes in Optical Applications

Nanomaterial interactions with biomembranes: Bridging the gap between soft matter models and biological context

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