Nanosafety research in Europe – Towards a focus on nano-enabled products

Pomar-Portillo, Vicenç; Park, Barry; Crossley, Alison; Vázquez‐Campos, Socorro

doi:10.1016/j.impact.2021.100323

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…caNanoLab allows submission and retrieval of NM characterization data, in vitro and in vivo assays, and associated nanotechnology protocols and publications in a secure environment. In Europe, more than 50 nanoEHS (Nano Environmental Health and Safety)-related projects have been funded over the last ten years or so, such as the funding programs FP6 (2002–2006), FP7 (2007–2013), and Horizon 2020 (2014–2020) . These projects resulted in a comprehensive platform for coordinating nanosafety research in Europe, the EU-NanoSafety Cluster.…”

Section: Nanotoxicity Data and Model-friendly Databasesmentioning

confidence: 99%

Converting Nanotoxicity Data to Information Using Artificial Intelligence and Simulation

et al. 2023

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Decades of nanotoxicology research have generated extensive and diverse data sets. However, data is not equal to information. The question is how to extract critical information buried in vast data streams. Here we show that artificial intelligence (AI) and molecular simulation play key roles in transforming nanotoxicity data into critical information, i.e., constructing the quantitative nanostructure (physicochemical properties)–toxicity relationships, and elucidating the toxicity-related molecular mechanisms. For AI and molecular simulation to realize their full impacts in this mission, several obstacles must be overcome. These include the paucity of high-quality nanomaterials (NMs) and standardized nanotoxicity data, the lack of model-friendly databases, the scarcity of specific and universal nanodescriptors, and the inability to simulate NMs at realistic spatial and temporal scales. This review provides a comprehensive and representative, but not exhaustive, summary of the current capability gaps and tools required to fill these formidable gaps. Specifically, we discuss the applications of AI and molecular simulation, which can address the large-scale data challenge for nanotoxicology research. The need for model-friendly nanotoxicity databases, powerful nanodescriptors, new modeling approaches, molecular mechanism analysis, and design of the next-generation NMs are also critically discussed. Finally, we provide a perspective on future trends and challenges.

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Section: Nanotoxicity Data and Model-friendly Databasesmentioning

confidence: 99%

Converting Nanotoxicity Data to Information Using Artificial Intelligence and Simulation

et al. 2023

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“…Nanotechnology is an emerging field promising innovative solutions in a wide range of applications that are expected to greatly contribute to sustainable development [ 217 ]. Nevertheless, the fast growth of nanotechnology research associated with the increased interest in novel systems and nanomaterials has not been completely followed by sufficient knowledge about safety and sustainability issues [ 218 , 219 , 220 , 221 , 222 ]. Hence, over the last few years, the scientific community from the diverse fields of the nanosafety framework has made an effort to focus research on identifying and understanding the potential risks and impacts that this emerging field may have on humans and the environment [ 221 ], as has been pointed out throughout this review.…”

Section: Life Cycle Assessment and Nanosafetymentioning

confidence: 99%

“…Nevertheless, the fast growth of nanotechnology research associated with the increased interest in novel systems and nanomaterials has not been completely followed by sufficient knowledge about safety and sustainability issues [ 218 , 219 , 220 , 221 , 222 ]. Hence, over the last few years, the scientific community from the diverse fields of the nanosafety framework has made an effort to focus research on identifying and understanding the potential risks and impacts that this emerging field may have on humans and the environment [ 221 ], as has been pointed out throughout this review. For instance, and as an outcome example, a series of tools has been developed under the scope of different European projects (e.g., NanoFase, NanoReg2, SUNSHINE, SbD4Nano, ASINA, and SAbyNA), some of which are still ongoing.…”

Section: Life Cycle Assessment and Nanosafetymentioning

confidence: 99%

Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment

et al. 2022

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The use of nanomaterials has been increasing in recent times, and they are widely used in industries such as cosmetics, drugs, food, water treatment, and agriculture. The rapid development of new nanomaterials demands a set of approaches to evaluate the potential toxicity and risks related to them. In this regard, nanosafety has been using and adapting already existing methods (toxicological approach), but the unique characteristics of nanomaterials demand new approaches (nanotoxicology) to fully understand the potential toxicity, immunotoxicity, and (epi)genotoxicity. In addition, new technologies, such as organs-on-chips and sophisticated sensors, are under development and/or adaptation. All the information generated is used to develop new in silico approaches trying to predict the potential effects of newly developed materials. The overall evaluation of nanomaterials from their production to their final disposal chain is completed using the life cycle assessment (LCA), which is becoming an important element of nanosafety considering sustainability and environmental impact. In this review, we give an overview of all these elements of nanosafety.

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“…The size and concentration of nanoparticles will affect the effect of nano-fertilizers, and may also produce toxic reactions. The effects need to be further studied [ 79 , 80 ].…”

Section: Effect Of Nanomaterials (Nms) On Nutritional Quality Of Agri...mentioning

confidence: 99%

Engineered Nanomaterials for Improving the Nutritional Quality of Agricultural Products: A Review

et al. 2022

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To ensure food safety, the current agricultural development has put forward requirements for improving nutritional quality and reducing the harmful accumulation of agricultural chemicals. Nano-enabled sustainable agriculture and food security have been increasingly explored as a new research frontier. Nano-fertilizers show the potential to be more efficient than traditional fertilizers, reducing the amount used while ensuring plant uptake, supplying the inorganic nutrients needed by plants, and improving the process by which plants produce organic nutrients. Other agricultural uses of nanotechnology affect crop productivity and nutrient quality in addition to nano-fertilizers. This article will review the research progress of using nanomaterials to improve nutritional quality in recent years and point out the focus of future research.

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Nanosafety research in Europe – Towards a focus on nano-enabled products

Cited by 6 publications

References 27 publications

Converting Nanotoxicity Data to Information Using Artificial Intelligence and Simulation

Converting Nanotoxicity Data to Information Using Artificial Intelligence and Simulation

Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment

Engineered Nanomaterials for Improving the Nutritional Quality of Agricultural Products: A Review

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