Nanorobots for improved theranostic applications

Anzar, Nigar; Yadav, Neelam; Narang, Jagriti

doi:10.1016/b978-0-323-85785-7.00002-4

Cited by 2 publications

(1 citation statement)

References 87 publications

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“…The utilization of light as a means of actuation in the field of micro and nanorobotics has gained significant traction, highlighting remarkable potential for diverse applications, including theranostics [91] and drug release mechanisms. [92] Light actuation enables precise control over micro and nanorobots by harnessing the unique properties of light, such as its noncontact nature, high precision, and ability to manipulate objects at small scales.…”

Section: Light Field Actuationmentioning

confidence: 99%

State of the Art in Actuation of Micro/Nanorobots for Biomedical Applications

Elnaggar,

Kang,

Tian

et al. 2024

Small Science

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The emergence of micro/nanorobotics stands poised to revolutionize various biomedical applications, given its potential to offer precision, reduced invasiveness, and enhanced functionality. In the face of such potential, understanding the mechanisms that drive these tiny robots, especially their actuation techniques, becomes critical. Although there is a surge in research dedicated to micro/nanorobotics, there exists a gap in consolidating the diverse actuation strategies and their suitability for biomedical applications. This comprehensive review seeks to bridge this gap by providing an in‐depth evaluation of the current actuation techniques employed by micro/nanorobots, particularly emphasizing their relevance and potential for clinical translation. The discussion starts by elucidating the different actuation strategies, ranging from magnetic, electric, acoustic, light‐based, to chemical and biological mechanisms. Then, various examples and meticulous assessment of each technique are offered, spotlighting their respective merits and limitations within a biomedical context. This review illuminates the transformative capabilities of these actuation methods in medicine. It not only highlights the progress made in this burgeoning field but also underscores the areas that require further exploration and development.

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Section: Light Field Actuationmentioning

confidence: 99%

State of the Art in Actuation of Micro/Nanorobots for Biomedical Applications

Elnaggar,

Kang,

Tian

et al. 2024

Small Science

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Nanomedicine: Treatment of Chronic Disease Using Gold Nano Thermo Robot (GNTR) Empowered With Nanotechnology Approaches

Hasan,

Fatima,

Shahzad

et al. 2024

IEEE Access

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Nanotechnologists and medical researchers are working hard to develop new and innovative ways to use nanorobots as nanomedicine to improve healthcare outcomes and revolutionize the field of therapeutics. Nanotechnology has the potential to revolutionize healthcare by providing new ways of treating chronic diseases in the field of medicine. A "Gold Nano Thermo Robot" (GNTR) model has been proposed in this research article, which can be considered a nanomedicine that will deliver controlled thermal therapy to targeted malignant tissues without damaging healthy tissues. The proposed nanotherapeutic system, empowered with a nano sensor network, interbody body communication network, and Internet of nanomedical things, has been used to normalize and control hyperthermal waves in real-time that have been used to eliminate breast cancer cells using the "SEE and TREAT" technique. To generate hyperthermia, which has been irradiated by laser pulses to propose GNTR, a Coulomb explosion took place, and a huge amount of dispersed hyperthermia waves were produced. To convert the intensity of dispersed and irregular hyperthermia into a regulated and disciplined format, a Finite Difference Method has been used to develop a "Heat Control System." A comparative analysis has been provided of the intricate relationship between the required radius of Gold Nano Thermo Robots and the volume depth of the tumor for penetration, with a keen focus on evaluating how different GNTR sizes fit or do not fit for the task of effectively treating tumors at various depths within cancer tumors. Furthermore, the effectiveness of treatment has multifaceted outcomes that have been acquired by the interplay between two critical factors, the temperature limit and therapy duration. By examining a comprehensive matrix of thermal therapy durations (ranging from 25 minutes to 60 minutes) alongside various temperature limits (ranging from 33°C to 60°C). The best fit and the best response therapy session have been verified with a temperature limit of 42 °C for 30 minutes, achieving near-complete tumor ablation with minimum harm to the healthy tissues. The complex physical effects on the Gold Nano Robots surfaces due to the Coulomb explosion procedure are also provided in the form of simulation analysis, and an explanation is given in nine panels. INDEX TERMSCoulomb explosion; nanotherapeutic system; nano sensor network; hyperthermia; nanomedicine; interbody body communication network; Internet of nanomedical things; finite difference method; see and treat technique. I.

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Nanorobots for improved theranostic applications

Cited by 2 publications

References 87 publications

State of the Art in Actuation of Micro/Nanorobots for Biomedical Applications

State of the Art in Actuation of Micro/Nanorobots for Biomedical Applications

Nanomedicine: Treatment of Chronic Disease Using Gold Nano Thermo Robot (GNTR) Empowered With Nanotechnology Approaches

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