Nanoreactors for Biomedical Applications

Itel, Fabian; Dinu, Ionel Adrian; Fischer, Ozana; Palivan, Cornelia G.

doi:10.1142/9789814520652_0064

Cited by 5 publications

(2 citation statements)

References 226 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,5 Molecular parameters of the BCP macromolecules, that is, molecular weight, chemistry of the blocks, and so forth, determine the properties of the final, self-assembled membrane. 6 The membrane properties can therefore be tuned by simply changing those molecular parameters to optimize the membrane for a desired technological application. Recently, biomimetic membranes based on BCPs have been successfully used for insertion of sensitive, biological MPs, 5,7−19 biopores/ ionophores, 20−22 and polysaccharide-based cell receptors.…”

mentioning

confidence: 99%

“…As an improved alternative to phospholipids, amphiphilic block copolymers (BCPs), which imitate the amphiphilic membrane-forming property of lipids, have gained much interest, especially due to the higher mechanical and chemical stability of the corresponding BCP membranes compared to phospholipid bilayers; − this is an essential requirement for advanced and high-throughput technological applications . Another advantage that is provided by BCP membranes is their ability to form a barrier with reduced permeability to water, ions and neutral molecules compared to natural lipid bilayer membranes. , Molecular parameters of the BCP macromolecules, that is, molecular weight, chemistry of the blocks, and so forth, determine the properties of the final, self-assembled membrane . The membrane properties can therefore be tuned by simply changing those molecular parameters to optimize the membrane for a desired technological application.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch

2015

Self Cite

View full text Add to dashboard Cite

The functioning of biological membrane proteins (MPs) within synthetic block copolymer membranes is an intriguing phenomenon that is believed to offer great potential for applications in life and medical sciences and engineering. The question why biological MPs are able to function in this completely artificial environment is still unresolved by any experimental data. Here, we have analyzed the lateral diffusion properties of different sized MPs within poly(dimethylsiloxane) (PDMS)-containing amphiphilic block copolymer membranes of membrane thicknesses between 9 and 13 nm, which results in a hydrophobic mismatch between the membrane thickness and the size of the proteins of 3.3-7.1 nm (3.5-5 times). We show that the high flexibility of PDMS, which provides membrane fluidities similar to phospholipid bilayers, is the key-factor for MP incorporation.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch

2015

Self Cite

View full text Add to dashboard Cite

show abstract

Therapeutic Nanoreactors as In Vivo Nanoplatforms for Cancer Therapy

Mukerabigwi

Kataoka

2018

Chemistry A European J

View full text Add to dashboard Cite

Therapeutic nanoreactors have been proposed as nanoplatforms to treat diseases through in situ production of therapeutic agents. When this treatment strategy is applied in cancer therapy, it can efficiently produce highly toxic anticancer drugs in situ from low-toxic prodrugs or some biomolecules in tumor tissues, which can maximize the therapeutic efficacy with a significantly low systemic toxicity. An ideal therapeutic nanoreactor can provide the reaction space, protect the loaded fragile catalysts, target the desired pathological site, and be selectively activated. In this minireview, we highlight the recent advances concerning the applications of therapeutic nanoreactors as in vivo nanoplatforms particularly in cancer therapy. Herein, the therapeutic nanoreactors are discussed on the basis of treatment strategies and various nanoparticles. Specifically, the treatment strategies of nanoreactors including single enzyme, single enzyme with chemodrugs, and multienzymes, as well as varying types of engineered nanoparticle-loaded active catalysts, primarily including liposomes, polymersomes, polymeric micelles, inorganic nanoparticles, and metal-organic framework (MOF) architectures, are documented and briefly discussed. Finally, we elucidate the current challenges to be addressed toward further development and translation into clinical applications of these therapeutic nanoreactors in cancer therapy.

show abstract

Enzymatic Sol-Gel Transition in Milk

Smykov,

Myagkonosov

2024

Colloid J

View full text Add to dashboard Cite

Nanoreactors for Biomedical Applications

Cited by 5 publications

References 226 publications

Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch

Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch

Therapeutic Nanoreactors as In Vivo Nanoplatforms for Cancer Therapy

Enzymatic Sol-Gel Transition in Milk

Contact Info

Product

Resources

About