Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

Tan, Justin; Wang, Yajun; Yip, Xiaopei; Glynn, Fergal; Shepherd, Robert K.; Caruso, Frank

doi:10.1002/adma.201200634

Cited by 76 publications

(77 citation statements)

References 34 publications

(21 reference statements)

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“…Delivery of drugs through the BBB could be attained by application of nanotechnology [62]. Nanotechnological advances for neurotrophin delivery systems are promising regarding their ability to activate neurotrophin signalling for neuroprotection and neuroregeneration [63]. Neurotrophins are indispensable for the development and functions of neurons and can be delivered to their site of action by CNTs [92,93].…”

Section: Carbon Nanotubes As Cns Drug Delivery Vehicles For the Treatmentioning

confidence: 99%

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Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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Extensive research on carbon nanotubes has been conducted due to their excellent physicochemical properties. Based on their outstanding physicochemical properties, carbon nanotubes have the potential to be employed as theranostic tools for neurological pathologies such as Alzheimer’s disease and Parkinson’s disease including ischemic stroke diagnosis and treatment. Stroke is currently regarded as the third root cause of death and the leading source of immobility around the globe. The development and improvement of efficient and effective procedures for central nervous system disease diagnosis and treatment is necessitated. The main aim of this review is to discuss the application of nanotechnology, specifically carbon nanotubes, to the diagnosis and treatment of neurological disorders with an emphasis on ischemic stroke. Areas covered include the conventional current diagnosis and treatment of neurological disorders, as well as a critical review of the application of carbon nanotubes in the diagnosis and treatment of ischemic stroke, covering areas such as functionalization of carbon nanotubes and carbon nanotube-based biosensors. A broad perspective on carbon nanotube stimuli-responsiveness, carbon nanotube toxicity, and commercially available carbon nanotubes is provided. Potential future studies employing carbon nanotubes have been discussed, evaluating their extent of advancement in the diagnosis and treatment of neurological and ischemic disorders.

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Section: Carbon Nanotubes As Cns Drug Delivery Vehicles For the Treatmentioning

confidence: 99%

“…This intensive selection of substances into the brain plays a crucial role in the regulation of homeostasis of the CNS. Moreover, it protects the CNS from invasion by foreign material such as toxins, viruses, bacteria, and other unwanted substances [15,62,63,100].…”

Section: Carbon Nanotubes As Cns Drug Delivery Vehicles For the Treatmentioning

confidence: 99%

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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“…43 Thus, emerging nanotechnologies for production of neurotrophin delivery systems are promising in terms of their ability to activate neurotrophin signaling for neuroprotection and neuroregeneration. 44 Neurotrophins are proteins that were initially recognized as being factors related to the survival of sympathetic and sensory neurons. Neurotrophins are essential for the development and function of neurons in both the CNS and PNS, and can be delivered using CNTs.…”

Section: Cnts In Drug Deliverymentioning

confidence: 99%

Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery

John¹,

Subramanian²,

Vellayappan³

et al. 2015

IJN

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Neuroregeneration is the regrowth or repair of nervous tissues, cells, or cell products involved in neurodegeneration and inflammatory diseases of the nervous system like Alzheimer’s disease and Parkinson’s disease. Nowadays, application of nanotechnology is commonly used in developing nanomedicines to advance pharmacokinetics and drug delivery exclusively for central nervous system pathologies. In addition, nanomedical advances are leading to therapies that disrupt disarranged protein aggregation in the central nervous system, deliver functional neuroprotective growth factors, and change the oxidative stress and excitotoxicity of affected neural tissues to regenerate the damaged neurons. Carbon nanotubes and graphene are allotropes of carbon that have been exploited by researchers because of their excellent physical properties and their ability to interface with neurons and neuronal circuits. This review describes the role of carbon nanotubes and graphene in neuroregeneration. In the future, it is hoped that the benefits of nanotechnologies will outweigh their risks, and that the next decade will present huge scope for developing and delivering technologies in the field of neuroscience.

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“…Polypeptide poly(L-glutamic acid) (PGA) Brain-derived neurotrophic factor (BDNF) [82] In vitro, Release of drug in SGF.…”

Section: Nanoporous Peptide Particlesmentioning

confidence: 99%

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

et al. 2016

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Currently, many sensitive molecules have been studied for effective oral administration. These substances are biologically active compounds that mainly suffer early degradation in the gastrointestinal tract (GIT) and physicochemical instability, inactivation and poor solubility and permeability. The sensibility of the biomolecules has limited their oral administration in the body and today is an important research topic to achieve desired effects in medicine field. Under this perspective, various enhancement approaches have been studied as alternatives to increase their oral bioavailability. Some of these strategies include functionalized polymers to provide specific useful benefits as protection to the intestinal tract by preventing its degradation by stomach enzymes, to increase their absorption, permeability, stability, and to make a proper release in the GIT. Due to specific chemical groups, shapes and sizes, morphologies, mechanical properties, and degradation, recent advances in functionalized polymers have opened the door to great possibilities to improve the physicochemical characteristics of these biopharmaceuticals. Today, many biomolecules are found in basic studies, preclinical steps, and others are late stage clinical development. This review summarizes the contribution of functionalized polymers to enhance oral bioavailability of sensitive molecules and their application status in medicine for different diseases. Future trends of these polymers and their possible uses to achieve different formulation goals for oral delivery are also covered in this manuscript.

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Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

Cited by 76 publications

References 34 publications

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Carbon nanotubes and graphene as emerging candidates in neuroregeneration and neurodrug delivery

Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules

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