Nanoporous Metal–Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide

Abstract

Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense Fe -TA complexes in nanoporous CaCO template particles. The particles have potential for the diagnostic detection of endogenous levels of H O ex vivo and in vivo by ultrasound imaging, which is based on the catalytic activity of the coordinated Fe in the particles to break down H O to O microbubbles.

Nanocatalytic Medicine

“…Copyright 2013, Wiley‐VCH; Image for 2014: Reproduced with permission . Copyright 2014, American Chemical Society; Image for 2015: Reproduced with permission . Copyright 2015, Wiley‐VCH; Image for 2016: Reproduced with permission .…”

“…Moreover, this strategy, which utilizes endogenous H 2 O 2 in pathological regions as a reactant to support such a catalytic process, can also confer high diagnostic specificity. As a representative paradigm, Guo et al first fabricated nanoporous metal‐phenolic particles that could respond to pathological H 2 O 2 and catalyze O 2 generation for enhancing US contrast ( Figure ) . Such a diagnostic nanosystem was fabricated by loading tannic acid (TA) and Fe 3+ in nanoporous CaCO 3 templates, followed by acid etching to enable the structure replication from CaCO 3 templates to the ultimate products (denoted np Fe III –TA RPs).…”

“…f) Brightness mode (B‐mode) and contrast enhanced US (CEU) images of the mouse livers in vivo. a–f) Reproduced with permission . Copyright 2015, Wiley‐VCH.…”

Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications

“…17,72 The galloyl or catechol groups within the polyphenol compounds provide sites for metal ions to cross-link, resulting in a stable yet flexible matrix around the template substrates. 43,73 Using this metal-polyphenol crosslinking and the natural affinity of polyphenols for various surfaces, a wide variety of functional materials (microcapsules, 43 replica particles, 74 nanoparticles, [75][76] superstructures, 77 synthetic spores, 78-79 etc.) have been engineered for a wide spectrum of biological applications.…”

Ultrasound Detection of Regional Oxidative Stress in Deep Tissues Using Novel Enzyme Loaded Nanoparticles

“…H 2 O 2 , the most common ROS, can increase by as much as fivefold in tissues injured by an ischemic event . Although many attempts have been made at detecting H 2 O 2 in vivo, translation of these methods remains elusive. Here, we introduce a novel translatable silica nanoshell as an ultrasound contrast agent to detect elevated levels of H 2 O 2 in tissues.…”