Nanoporous hybrid core–shell nanoparticles for sequential release

Abstract

Silica inside – organosilica outside, and nanoporous throughout: Drug molecules to be released sequentially from novel core–shell nanoparticles select their location (core/shell) autonomously.

Preparation of Magnetic–Luminescent Bifunctional Rapeseed Pod-Like Drug Delivery System for Sequential Release of Dual Drugs

“…The strategy of a rapid release of vancomycin for the initial 2 days, followed by sustained release of recombinant human bone morphogenetic protein-2, was used to inhibit bacterial invasion at the initial stage and later promote the behavior of related osteogenesis cells for favorable osteointegration after dental implantation [ 31 ]. Apparently, DDSs with a more complex structure are required to induce the sequential release of multiple drugs, such as core–shell micro/nanoparticles, and fibers [ 32 , 33 , 34 , 35 ]. Nie et al [ 36 ] prepared poly( l -lactide)/poly(lactide- co -glycolide) (PLGA) core–shell microspheres by coaxial electrohydrodynamic atomization, in which suramin and paclitaxel were loaded in the core and shell layers, respectively.…”

Porous spherical gold nanoparticles via a laser induced process

“…These properties make them interesting for many areas of application such as catalysis, optical detection methods or biomedical applications. 7–9…”

“…These properties make them interesting for many areas of application such as catalysis, optical detection methods or biomedical applications. [7][8][9] The starting materials for manufacturing porous metals as particles or surfaces, as is used in the present item, are alloys from which the less noble metal is dissolved out. 7,10,11 For example, in, ref.…”

Synthesis of Cyclen‐Functionalized Ethenylene‐Based Periodic Mesoporous Organosilica Nanoparticles and Metal‐Ion Adsorption Studies

“…The development of Mesoporous Organosilica Nanoparticles (MON) has grown a lot the last decade for different applications, mainly drug delivery, but also catalysis. The field has been comprehensively reviewed [1] and recent examples have shown elaboration of complex core‐shell structures allowing sequential release of hydrophobic and hydrophilic drugs [2] . Regarding the emerging environmental applications field, the extraction of heavy metal ions from water was studied.…”

“…The field has been comprehensively reviewed [1] and recent examples have shown elaboration of complex core-shell structures allowing sequential release of hydrophobic and hydrophilic drugs. [2] Regarding the emerging environmental applications field, the extraction of heavy metal ions from water was studied. Hybrid organicinorganic mesoporous silica-based materials in bulk were first investigated.…”