Nanoporous gold film based immunosensor for label-free detection of cancer biomarker

Wei, Qin; Zhao, Yanfang; Xu, Caixia; Wu, Dan; Cai, Yanyan; He, Jing; Li, He; Du, Bin; Yang, Minghui

doi:10.1016/j.bios.2011.02.024

Cited by 96 publications

(41 citation statements)

References 26 publications

(15 reference statements)

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“…The linear range for this sensor was reported to be 0.02 to 14 ng/mL with a detection limit of 6.31 pg/mL [126]. In another similar study, prostatespecific antigen (PSA) served as the analyte using an anti-PSA antibody-immobilized nanoporous gold film on glassy carbon and potassium ferricyanide as the redox probe was described [127]. The linear range was reported to be 0.05-26 ng/mL with a detection limit of 3 pg/mL [127].…”

Section: Electrochemicalmentioning

confidence: 97%

“…In another similar study, prostatespecific antigen (PSA) served as the analyte using an anti-PSA antibody-immobilized nanoporous gold film on glassy carbon and potassium ferricyanide as the redox probe was described [127]. The linear range was reported to be 0.05-26 ng/mL with a detection limit of 3 pg/mL [127]. In all three studies, the dealloying time, which influences pore size and the amount of residual silver, was investigated [125][126][127].…”

Section: Electrochemicalmentioning

confidence: 99%

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Nanoporous Gold Electrodes and Their Applications in Analytical Chemistry

Collinson

2013

ISRN Analytical Chemistry

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Nanoporous gold prepared by dealloying Au:Ag alloys has recently become an attractive material in the field of analytical chemistry. This conductive material has an open, 3D porous framework consisting of nanosized pores and ligaments with surface areas that are 10s to 100s of times larger than planar gold of an equivalent geometric area. The high surface area coupled with an open pore network makes nanoporous gold an ideal support for the development of chemical sensors. Important attributes include conductivity, high surface area, ease of preparation and modification, tunable pore size, and a bicontinuous open pore network. In this paper, the fabrication, characterization, and applications of nanoporous gold in chemical sensing are reviewed specifically as they relate to the development of immunosensors, enzyme-based biosensors, DNA sensors, Raman sensors, and small molecule sensors.

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Section: Electrochemicalmentioning

confidence: 97%

Section: Electrochemicalmentioning

confidence: 99%

Nanoporous Gold Electrodes and Their Applications in Analytical Chemistry

Collinson

2013

ISRN Analytical Chemistry

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“…NPG has been the subject of much attention for a range of applications including catalysis [4][5][6], optical sensing [7,8] and analysis [9]. NPG electrodes have been used in the development of immunosensors [10][11][12], DNA sensors [13,14], enzymatic biosensors [15,16] and as enzyme-free sensors [17][18][19]. 35 In this mini-review, we describe the use of dealloyed NPG for bioelectrochemical applications in biosensors and enzymatic biofuel cells.…”

Section: Introductionmentioning

confidence: 99%

An overview of dealloyed nanoporous gold in bioelectrochemistry

Xiao

Magner

2016

Bioelectrochemistry

112

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“…NPAu film-modified electrode was recently used in the construction of label-free immunosensors for PSA detection (Wei et al, 2011). Taking advantage of the large surface area of NPAu, a great amount of PSA antibodies could be absorbed into its pores.…”

Section: Gold Nanomaterialsmentioning

confidence: 99%

Detection of Cancer Biomarkers With Nanotechnology

Zhang

et al. 2013

American Journal of Biochemistry and Biotechnology

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Early detection of cancer biomarkers with high precision is critically important for cancer therapy. A variety of sensors based on different nanostructured materials have attracted intensive research interest due to their potential for highly sensitive and selective detection of cancer biomarkers. This review covers the use of a variety of nanostructured materials, including carbon nanotubes, silicon nanowires, gold nanoparticles and quantum dots, in the fabrication of sensors. Emphases are placed on how the detection systems work and what detection limits can be achieved. Some assays described in this review outperform established methods for cancer biomarker detection. It is highly promising that these sensors would soon move into commercial-scale production and find routine use in hospitals.

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Nanoporous gold film based immunosensor for label-free detection of cancer biomarker

Cited by 96 publications

References 26 publications

Nanoporous Gold Electrodes and Their Applications in Analytical Chemistry

Nanoporous Gold Electrodes and Their Applications in Analytical Chemistry

An overview of dealloyed nanoporous gold in bioelectrochemistry

Detection of Cancer Biomarkers With Nanotechnology

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