Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide

Hu, Xiaoxiao; Wang, Caifen; Wang, Lebing; Liu, Zhaoxin; Wu, Li; Zhang, Guoqing; Yu, Lingfei; Ren, Xiuyan; York, Peter; Sun, Lixin; Zhang, Jiwen; Li, Haiyan

doi:10.1016/j.ijpharm.2019.04.030

Cited by 60 publications

(37 citation statements)

References 27 publications

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“…Cyclodextrin metal-organic frameworks (CD-MOFs) have recently been described as a new type of particle which is the result of the combination between cyclodextrins and potassium ions [63]. The objective is to produce porous cubic powder particles supposed to be associated with a good lung deposition.…”

Section: Pore Forming Agentsmentioning

confidence: 99%

Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review

Lechanteur

Évrard

2020

Pharmaceutics

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Although dry powder inhalers (DPIs) have attracted great interest compared to nebulizers and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to enhance therapeutic activity. Indeed, it is estimated that only 10–15% of the drug reaches the deep lung while 20% of the drug is lost in the oropharyngeal sphere and 65% is not released from the carrier. The potentiality of the powders to disperse in the air during the patient’s inhalation, the aerosolization, should be optimized. To do so, new strategies, in addition to classical lactose-carrier, have emerged. The lung deposition of carrier-free particles, mainly produced by spray drying, is higher due to non-interparticulate forces between the carrier and drug, as well as better powder uniformity and aerosolization. Moreover, the association of two or three active ingredients within the same powder seems easier. This review is focused on a new type of carrier-free particles which are characterized by a sugar-based core encompassed by a corrugated shell layer produced by spray drying. All excipients used to produce such particles are dissected and their physico-chemical properties (Péclet number, glass transition temperature) are put in relation with the lung deposition ability of powders. The importance of spray-drying parameters on powders’ properties and behaviors is also evaluated. Special attention is given to the relation between the morphology (characterized by a corrugated surface) and lung deposition performance. The understanding of the closed relation between particle material composition and spray-drying process parameters, impacting the final powder properties, could help in the development of promising DPI systems suitable for local or systemic drug delivery.

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Section: Pore Forming Agentsmentioning

confidence: 99%

Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review

Lechanteur

Évrard

2020

Pharmaceutics

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“…However, most of these studies have focused on enhancing the solubility, stability and bioavailability of drugs 40 , 41 . It is noteworthy that budesonide has been reported being encapsulated in the pores of CD-MOF as a new inhalers of pulmonary drug delivery due to its uniform inhalation size 42 . All in all, CD-MOF has the characteristics of special porous for loading of insoluble drugs, uniform controllable cubic morphology and size for quality control and high portability, which provide the basis for inhalable CD-MOF particles as a potential new carrier for laryngeal administration in the field of laryngeal delivery.…”

Section: Introductionmentioning

confidence: 99%

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Zhao

Guo

Wang

et al. 2020

Acta Pharmaceutica Sinica B

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It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ -cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.

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“…Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide Xiaoxiao Hu et al, [44], 2019…”

Section: Control Of Nucleation and Growthmentioning

confidence: 99%

“…The modified preparation process of MOFs made smaller particles with a 1-10 μm using cetyltrimethyl ammonium bromide as a capping agent. Also, the synthesis of CD-MOFs with a smaller size than 40 μm needed a long incubation time of about 24-32 h. Therefore, having this in mind and by a solvothermal method in temperature of 50 C, Hu and coworkers could prepare porous CD-MOF crystals with uniform and proper size (with most of the particles in the range of 2-3 μm) for pulmonary drug delivery and inhalation administration [44].…”

Section: Particle Sizementioning

confidence: 99%

An investigation of affecting factors on MOF characteristics for biomedical applications: A systematic review

Ahmadi

Ayyoubzadeh

Ghorbani‐Bidkorbeh

et al. 2021

Heliyon

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Metal-organic frameworks (MOFs) are a fascinating class of crystalline porous materials composed of metal ions and organic ligands. Due to their attractive properties, MOFs can potentially offer biomedical field applications, such as drug delivery and imaging. This study aimed to systematically identify the affecting factors on the MOF characteristics and their effects on structural and biological characteristics. An electronic search was performed in four databases containing PubMed, Scopus, Web of Science, and Embase, using the relevant keywords. After analyzing the studies, 20 eligible studies were included in this review. As a result, various factors such as additives and organic ligand can influence the size and structure of MOFs. Additives are materials that can compete with ligand and may affect the nucleation and growth processes and, consequently, particle size. The nature and structure of ligand are influential in determining the size and structure of MOF. Moreover, synthesis parameters like the reaction time and initial reagents ratio are critical factors that should be optimized to regulate the size and structure. Of note is that the nature of the ligand and using a suitable additive can control the porosity of MOF. The more extended ligands aid in forming large pores. The choice of metallic nodes and organic ligand, and the MOF concentration are important factors since they can determine toxicity and biocompatibility of the final structure. The physicochemical properties of MOFs, such as hydrophobicity, affect the toxicity of nanoparticles. An increase in hydrophobicity causes increased toxicity of MOF. The biodegradability of MOF, as another property, depends on the organic ligand and metal ion and environmental conditions like pH. Photocleavable ligands can be served for controlled degradation of MOFs. Generally, by optimizing these affecting factors, MOFs with desirable properties will be obtained for biomedical applications.

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Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide

Cited by 60 publications

References 27 publications

Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review

Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

An investigation of affecting factors on MOF characteristics for biomedical applications: A systematic review

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