Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability inTrypanosoma brucei
Marija Krasiļņikova,
Catarina A. Marques,
Emma M. Briggs
et al.
Abstract:The genome of Trypanosoma brucei is structurally complex. Eleven megabase-sized chromosomes each comprise a transcribed core flanked by silent subtelomeres, housing thousands of Variant Surface Glycoprotein (VSG) genes. Additionally, silent VSGs are also found on hundreds of sub-megabase chromosomes that harbour 177 bp repeats of unknown function, and multiple VSG transcription sites localise to the telomeres of both chromosome types. DNA replication dynamics have been described in the megabase chromosome core… Show more
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