Nanopore Detection of Cancer Biomarkers: A Challenge to Science

Abstract

Cancer is the most complex and leading cause of fatality worldwide. Despite meritorious research in the field of cancer, it is still a substantial threat to human life. In this article, we address a question on the present strategies and manifest the importance of critical biomarkers for cancer screening and early diagnosis before the symptoms appear. However, this goal can only be achieved if scientists will focus on ultra-sensitive detection techniques such as “Nanopore.” Nanopore sensing is a simple and rapid single-molecule detection technique that can detect multiple cancer biomarkers in femto-Molar concentrations in real time. Last but not least, we propose a systematic policy to win the war against cancer that is a big challenge to science.

Glass Capillary-Based Nanopores for Single Molecule/Single Cell Detection

“…Nanopore detection (analytics) is an emerging single molecule detection technique that uses ionic conductivity variation in small nanoscale pores to “visualize” the binding process or translocation event of single molecules to their targets at the nanoscale. , Because of its low cost, label-free quality, high stability and sensitivity, and easy functionalization of pore size and surface properties (especially for solid-state nanopores), it has been widely used in single cell and single molecule detections and in diagnostic sensing and assays of cancers. − …”