Nanoplatform Self‐Assembly from Small Molecules of Porphyrin Derivatives for NIR‐II Fluorescence Imaging Guided Photothermal‐Immunotherapy

Abstract

Combinatorial photothermal and immunotherapy have demonstrated great potential to remove primary tumors, suppress metastases, and prevent tumor recurrence. However, this strategy still confronts with many limitations, such as complex components, sophisticated construction and inadequate therapeutic e cacy. In this work, we develop small molecules of porphyrin derivatives (PPor) which can selfassemble into monodispersed nanoparticles without supplement of any other ingredients or surfactants.The formed PPor nanoparticles (PPor NPs) exhibit highly photothermal conversion efficiency of 70% and NIR-II luminous abilities originated from the strong intramolecular charge transfer (ICT) effect of D-A structure under 808 nm laser irradiation, thus achieving NIR-II uorescence imaging guided photothermal therapy (PTT) against primary tumor with a high cure rate. More importantly, tumor-associated antigens (TAAs) together with damage-associated molecular patterns (DAMPs) released from PTT-treated cancer cells are proved to elicit immune responses in some degree. After combination with programmed cell death-1 (PD-1) antibody, a robust systematic antitumor immunity are generated to restrain both primary and abscopal tumors growth, prolong survival, prevent pulmonary metastasis on an aggressive 4T1 murine breast tumor model. Thus, this study provides a promising therapeutic paradigm with porphyrin derivatives nano-assembly as phototheranostic agents for the treatment of aggressive tumor with high e ciency.

Design of Sonosensitizers Integrated with Resveratrol Motif for Synergetic Sonodynamic Therapy and Nuclear Factor Kappa B Transcription Suppression of Breast Cancer

“…The electron excitation of the compounds showed a poor overlapping between the electron and hole, indicating a typical charge transfer characteristic (Figure S3). 28 The calculated oscillator strength (f) also proved that TR2 and TR3 were more easily excited to S 1 than TR1. 29 These calculations showed that the f and ΔE ST of TR2 and TR3 were close in values, which could explain their similar 1 O 2 production under ultrasonic treatment.…”

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

“…(B) The chemical structure of PPor and self-assembly to form PPor nanoparticles, and their fluorescence intensity spectrum. Reproduced with permission from refs and . Copyright 2021, The Author(s), Published by Springer Nature under a Creative Commons (CC BY) 4.0 International License.…”

Porphyrin‐Based Nanoparticles: A Promising Phototherapy Platform

“…Combining ICB with phototherapy is one of the methods to improve the efficacy of ICB. [192][193][194] In order to effectively combine ICB with phototherapy and obtain efficient and safe combined treatment, Cao et al [195] proposed a porphyrin-based nanoparticles (PPor NPs) with a D-A structure. Based on the strong intramolecular charge transfer (ICT) effect of the D-A structure, the nanoparticles exhibited excellent NIR-I absorption and NIR-II fluorescence emission and showed a photothermal conversion efficiency of 70% under 808 nm laser irradiation.…”