Nanoplastics exposure induces vascular malformation by interfering with the VEGFA/VEGFR pathway in zebrafish (Danio rerio)

Dai, Lu; Luo, Juanjuan; Feng, Meilan; Wang, Maya Zhe; Zhang, Jiannan; Cao, Xiaoqian; Yang, Xiaojun; Li, Juan

doi:10.1016/j.chemosphere.2022.137360

Cited by 12 publications

(3 citation statements)

References 57 publications

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“…Additionally, NP exposure led to vascular malformation by modulating VEGFA/VEGFR pathway-correlated gene expression during the early developmental stages of zebrafish. Thus, their findings demonstrated the toxicological effects of NPs on the development of the cardiovascular system [95]. Santos et al investigated vasotoxicity, developmental toxicity, cytotoxicity, and behavioral impairments in zebrafish induced by NPs exposure.…”

Section: Toxicities In Other Animal Cellsmentioning

confidence: 99%

An Emerging Role of Micro- and Nanoplastics in Vascular Diseases

Lee,

Yoon,

Kim

et al. 2024

Life

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Vascular diseases are the leading causes of death worldwide, and they are attributable to multiple pathologies, such as atherosclerosis, diabetes, and chronic obstructive pulmonary disease. Exposure to various environmental contaminants is associated with the development of various diseases, including vascular diseases. Among environmental contaminants, micro- and nanoplastics have gained attention as global environmental risk factors that threaten human health. Recently, extensive research has been conducted on the effects of micro- and nanoplastics on various human diseases, including vascular diseases. In this review, we highlight the effects of micro- and nanoplastics on vascular diseases.

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Section: Toxicities In Other Animal Cellsmentioning

confidence: 99%

An Emerging Role of Micro- and Nanoplastics in Vascular Diseases

Lee,

Yoon,

Kim

et al. 2024

Life

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“…Impeding intestinal angiogenesis can diminish nutrient absorption and stunt animal growth . Nanoplastics have been shown to inhibit subintestinal angiogenesis in transgenic zebrafish embryos and interfere with the vascular endothelial growth factor (VEGF-A) pathway, leading to vascular malformations during early developmental stages in zebrafish embryos . A previous study showed that exposure to MPs increased reactive oxygen species (ROS) levels in the intestine .…”

Section: Introductionmentioning

confidence: 99%

“…11 Nanoplastics have been shown to inhibit subintestinal angiogenesis in transgenic zebrafish embryos 12 and interfere with the vascular endothelial growth factor (VEGF-A) pathway, leading to vascular malformations during early developmental stages in zebrafish embryos. 13 A previous study showed that exposure to MPs increased reactive oxygen species (ROS) levels in the intestine. 14 Our previous study showed that elevated ROS can impair vascular endothelial cell function and reduce angiogenesis in the intestine.…”

Section: Introductionmentioning

confidence: 99%

Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway

Zou,

Yang,

et al. 2024

J. Agric. Food Chem.

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Due to the immature intestinal digestion, immunity, and barrier functions, weaned infants are more susceptible to pathogens and develop diarrhea. Microplastics (MPs), pervasive contaminants in food, water, and air, have unknown effects on the intestinal development of weaned infants. This study explored the impact of polystyrene MPs on intestinal development using a weaned piglet model. Piglets in the control group received a basal diet, and those in the experimental groups received a basal diet contaminated with 150 mg/kg polystyrene MPs. The results showed that exposure to polystyrene MPs increased the diarrhea incidence and impaired the intestinal barrier function of weaned piglets. Notably, the exposure led to oxidative stress and inflammation in the intestine. Furthermore, polystyrene MPs-treated weaned piglets showed a reduced level of intestinal angiogenesis. Mechanistically, polystyrene MPs suppressed methyltransferase-like 3 (METTL3) expression by increasing reactive oxygen species (ROS) production, consequently destabilizing angiogenic factors' mRNA and hindering intestinal angiogenesis. In summary, polystyrene MPs contamination in the diet increases diarrhea and compromises intestinal angiogenesis through the ROS/ METTL3 pathway, demonstrating their toxic effects on the intestine health of weaned infants.

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