Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells

Weber, Annkatrin; Schwiebs, Anja; Solhaug, Helene; Stenvik, Jørgen; Nilsen, Asbjørn Magne; Wagner, Martin; Relja, Borna; Radeke, Heinfried H.

doi:10.1016/j.envint.2022.107173

Cited by 67 publications

(33 citation statements)

References 61 publications

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“…It is known that microplastics are ubiquitous, and humans are exposed to them. Literature has depicted several risks to human health due to exposure to microplastics, mainly inflammation [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] . Recently, some authors revealed a correlation between fecal microplastics and inflammatory bowel disease [31] .…”

Section: Resultsmentioning

confidence: 99%

The impact of plastic during the COVID-19 pandemic: The point of view of the environmental science literature

Sousa

2023

Materials Today: Proceedings

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Section: Resultsmentioning

confidence: 99%

The impact of plastic during the COVID-19 pandemic: The point of view of the environmental science literature

Sousa

2023

Materials Today: Proceedings

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“…We also observe that MPs and NPs are internalized (Figure S3A) inducing reduction of proliferation in U-937 monocytes cell line after 48 h exposure (Figure S3B), although they do not induce monocyte differentiation as compared to PMA treatment (Figure S3C). These results could be due to the use of spherical NP and MP particles that might underestimate their immunogenic properties (Weber et al, 2022), so they might not be harmful on our immune cells model.…”

Section: [U-13 C 6 ]Glucose and [U-13 C 5 ]Glutamine Labeling Confirm...mentioning

confidence: 94%

Polystyrene Micro and Nano-Particles Induce Metabolic Rewiring in Normal Human Colon Cells: A Risk Factor for Human Health

Bonanomi¹,

Salmistraro²,

Porro³

et al. 2022

SSRN Journal

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“…Strong macrophage-mediated immune effects, such as various (non-) immunological foreign body responses to polymer implant wear particles, have been observed in both human patients and animals already for decades (Goodman et al, 1994;Wooley et al, 2002;Vasconcelos et al, 2016;Wright and Kelly, 2017). More recently also information about the immunological responses of cells and organisms to MPs have been published (Hirt and Body-Malapel, 2020;González-Fernández and Cuesta, 2022;Weber et al, 2022). These reactions to polymer particles can be considered red flags when reflecting on the potential for similar effects induced by MPs.…”

Section: Microplasticsmentioning

confidence: 99%

Relationship Between Particle Properties and Immunotoxicological Effects of Environmentally-Sourced Microplastics

Beijer¹,

Dehaut²,

Carlier³

et al. 2022

Front. Water

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BackgroundConcerns on microplastics (MPs) in food are increasing because of our increased awareness of daily exposure and our knowledge gap on their potential adverse health effects. When particles are ingested, macrophages play an important role in scavenging them, potentially leading to an unwanted immune response. To elucidate the adverse effects of MPs on human health, insights in the immunotoxicity of MPs are essential.ObjectivesTo assess the effect of environmentally collected ocean and land weathered MP particles on the immunological response of macrophages using a state-of-the art in vitro immunotoxicity assay specifically designed for measuring particle toxicity.MethodsEnvironmentally-weathered macroplastic samples were collected from the North Pacific Subtropical Gyre and from the French coastal environment. Macroplastics were identified using (micro)Raman-spectrometry, FT-IR and Py-GC-MS and cryo-milled to obtain size-fractionated samples up to 300 μm. Physiochemical MP properties were characterized using phase contrast microscopy, gel-permeation chromatography, nuclear magnetic resonance, and differential scanning colorimetry. Macrophages (differentiated THP-1 cells) were exposed to particles (<300 μm) for 48 h before assessment of cell viability and cytokine release. Using both the physiochemical particle properties and biological data, we performed multi-dimensional data analysis to explore relationships between particle properties and immunotoxicological effects.ResultsWe investigated land-derived polyethylene, polypropylene, polystyrene, and polyethylene terephthalate, water-derived polypropylene macroplastics, and virgin polyethylene fibers and nylon MPs. The different plastic polymeric compositions and MP size classes induced distinct cytokine responses. Macrophages had the largest response to polyethylene terephthalate-particle exposure, including a dose-related increase in IL-1β, IL-8, and TNF-α secretion. Smaller MPs induced cytokine production at lower concentrations. Additionally, a relationship between both physical and chemical particle properties and the inflammatory response of macrophages was found.DiscussionThis research shows that MP exposure could lead to an inflammatory response in vitro, depending on MP material and size. Whether this implies a risk to human health needs to be further explored.

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Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells

Cited by 67 publications

References 61 publications

The impact of plastic during the COVID-19 pandemic: The point of view of the environmental science literature

The impact of plastic during the COVID-19 pandemic: The point of view of the environmental science literature

Polystyrene Micro and Nano-Particles Induce Metabolic Rewiring in Normal Human Colon Cells: A Risk Factor for Human Health

Relationship Between Particle Properties and Immunotoxicological Effects of Environmentally-Sourced Microplastics

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