Nanopillar array-based plasmonic metasurface for switchable multifunctional biosensing

Cui, Songya; Tian, Chengxiang; Mao, Jikai; Wu, Wei; Fu, Yongqi

doi:10.1016/j.optcom.2021.127548

Cited by 13 publications

(4 citation statements)

References 43 publications

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“…Since its inception, this technology has received a large amount of attention because it allows for the fabrication of uniform, periodic nanostructures of SERS substrates. Thus, silicon nanopillars modified with metal nanoparticles with a high surface-to-volume ratio have proven their effectiveness in detecting various biomolecules [ 103 , 104 , 105 ]. Today, special attention is also paid to the fabrication of SERS substrates using biomimetic natural materials as a template for the further distribution of plasmonic nanostructures.…”

Section: Application Of Sers and Sers-combined Raman Techniques In The Detection Of Biomoleculesmentioning

confidence: 99%

Raman Scattering-Based Biosensing: New Prospects and Opportunities

et al. 2021

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The growing interest in the development of new platforms for the application of Raman spectroscopy techniques in biosensor technologies is driven by the potential of these techniques in identifying chemical compounds, as well as structural and functional features of biomolecules. The effect of Raman scattering is a result of inelastic light scattering processes, which lead to the emission of scattered light with a different frequency associated with molecular vibrations of the identified molecule. Spontaneous Raman scattering is usually weak, resulting in complexities with the separation of weak inelastically scattered light and intense Rayleigh scattering. These limitations have led to the development of various techniques for enhancing Raman scattering, including resonance Raman spectroscopy (RRS) and nonlinear Raman spectroscopy (coherent anti-Stokes Raman spectroscopy and stimulated Raman spectroscopy). Furthermore, the discovery of the phenomenon of enhanced Raman scattering near metallic nanostructures gave impetus to the development of the surface-enhanced Raman spectroscopy (SERS) as well as its combination with resonance Raman spectroscopy and nonlinear Raman spectroscopic techniques. The combination of nonlinear and resonant optical effects with metal substrates or nanoparticles can be used to increase speed, spatial resolution, and signal amplification in Raman spectroscopy, making these techniques promising for the analysis and characterization of biological samples. This review provides the main provisions of the listed Raman techniques and the advantages and limitations present when applied to life sciences research. The recent advances in SERS and SERS-combined techniques are summarized, such as SERRS, SE-CARS, and SE-SRS for bioimaging and the biosensing of molecules, which form the basis for potential future applications of these techniques in biosensor technology. In addition, an overview is given of the main tools for success in the development of biosensors based on Raman spectroscopy techniques, which can be achieved by choosing one or a combination of the following approaches: (i) fabrication of a reproducible SERS substrate, (ii) synthesis of the SERS nanotag, and (iii) implementation of new platforms for on-site testing.

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Section: Application Of Sers and Sers-combined Raman Techniques In The Detection Of Biomoleculesmentioning

confidence: 99%

Raman Scattering-Based Biosensing: New Prospects and Opportunities

et al. 2021

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“…Here, we present a platform with nanoscale topography that combines biochemical and physical cues for regulating cell processes. Biomaterials with nanoscale topography have become increasingly attractive for regulating cell processes for a wide range of application in areas such as tissue engineering, − drug delivery, discovery, and development, − biosensing, − electrophysiology, as well as fundamental cell biology, biophysics, and mechanobiology. − One type of nanotopographies that has gained significant attention is repeating patterns of free-standing cylinders with diameters of few hundred nanometers commonly known as nanopillar arrays . Several studies have shown that cells on nanopillars display behaviors distinct from those on flat surfaces affecting crucial cellular processes including endocytosis, − adhesion, proliferation, , migration, , and differentiation. − These findings have propelled the development of advanced applications by leveraging nanopillar-induced changes in cellular processes.…”

Section: Introductionmentioning

confidence: 99%

Engineering the Cellular Microenvironment: Integrating Three-Dimensional Nontopographical and Two-Dimensional Biochemical Cues for Precise Control of Cellular Behavior

Sarikhani,

Meganathan,

Larsen

et al. 2024

ACS Nano

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The development of biomaterials capable of regulating cellular processes and guiding cell fate decisions has broad implications in tissue engineering, regenerative medicine, and cell-based assays for drug development and disease modeling. Recent studies have shown that three-dimensional (3D) nanoscale physical cues such as nanotopography can modulate various cellular processes like adhesion and endocytosis by inducing nanoscale curvature on the plasma and nuclear membranes. Two-dimensional (2D) biochemical cues such as protein micropatterns can also regulate cell function and fate by controlling cellular geometries. Development of biomaterials with precise control over nanoscale physical and biochemical cues can significantly influence programming cell function and fate. In this study, we utilized a laser-assisted micropatterning technique to manipulate the 2D architectures of cells on 3D nanopillar platforms. We performed a comprehensive analysis of cellular and nuclear morphology and deformation on both nanopillar and flat substrates. Our findings demonstrate the precise engineering of single cell architectures through 2D micropatterning on nanopillar platforms. We show that the coupling between the nuclear and cell shape is disrupted on nanopillar surfaces compared to flat surfaces. Furthermore, our results suggest that cell elongation on nanopillars enhances nanopillar-induced endocytosis. We believe our platform serves as a versatile tool for further explorations into programming cell function and fate through combined physical cues that create nanoscale curvature on cell membranes and biochemical cues that control the geometry of the cell.

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“…Nanopillars are powerful platforms for cellular biophysics and bioengineering. In recent years, platforms with nanoscale topography have become increasingly attractive for supporting cell growth for a wide range of application in areas such as tissue engineering [1][2][3] , drug delivery, discovery, and development [4][5][6] , biosensing [7][8][9] , electrophysiology 10 , as well as fundamental cell biology, biophysics and mechanobiology. One type of nanostructured platform that has gained significant attention are repeating patterns of free-standing cylinders with diameters of few hundred nanometers commonly known as nanopillar arrays.…”

Section: Introductionmentioning

confidence: 99%

Engineering cell and nuclear morphology on nano topography by contact-free protein micropatterning

Sarikhani,

Meganathan,

Rahmani

et al. 2023

Preprint

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Platforms with nanoscale topography have recently become powerful tools in cellular biophysics and bioengineering. Recent studies have shown that nanotopography affects various cellular processes like adhesion and endocytosis, as well as physical properties such as cell shape. To engineer nanopillars more effectively for biomedical applications, it is crucial to gain better control and understanding of how nanopillars affect cell and nuclear physical properties, such as shape and spreading area, and impact cellular processes like endocytosis and adhesion. In this study, we utilized a laser-assisted micropatterning technique to manipulate the 2D architectures of cells on 3D nanopillar platforms. We performed a comprehensive analysis of cellular and nuclear morphology and deformation on both nanopillar and flat substrates. Our findings demonstrate precise engineering of cellular architectures through 2D micropatterning on nanopillar platforms. We show that the coupling between nuclear and cell shape is disrupted on nanopillar surfaces compared to flat surfaces. Furthermore, we discovered that cell elongation on nanopillars enhances nanopillar-induced endocytosis. These results have significant implications for various biomedical applications of nanopillars, including drug delivery, drug screening, intracellular electrophysiology, and biosensing. We believe our platform serves as a versatile tool for further explorations, facilitating investigations into the interplay between cell physical properties and alterations in cellular processes.

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Nanopillar array-based plasmonic metasurface for switchable multifunctional biosensing

Cited by 13 publications

References 43 publications

Raman Scattering-Based Biosensing: New Prospects and Opportunities

Raman Scattering-Based Biosensing: New Prospects and Opportunities

Engineering the Cellular Microenvironment: Integrating Three-Dimensional Nontopographical and Two-Dimensional Biochemical Cues for Precise Control of Cellular Behavior

Engineering cell and nuclear morphology on nano topography by contact-free protein micropatterning

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