Nanopatterned Bulk Metallic Glass Biosensors

Kinser, Emily; Padmanabhan, Jagannath; Yu, Roy; Corona, Sydney L.; Li, Jinyang; Vaddiraju, Santhisagar; Legassey, Allen; Loye, Ayomiposi M.; Balestrini, Jenna L.; Solly, Dawson A.; Schroers, Jan; Taylor, André D.; Papadimitrakopoulos, Fotios; Herzog, Raimund I.; Kyriakides, Themis R.

doi:10.1021/acssensors.7b00455

Cited by 27 publications

(12 citation statements)

References 40 publications

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“…It is also important to note that recent reports on approaches to improve sensor sensitivity by way of increased surface area and biocompatibility on glass, graphene, and biomass-derived nanocomposites have demonstrated the unique utility of techniques, such as nanopatterning, activated carbon transition metal oxides, and graphene nanomesh technology [ 34 , 35 , 36 ]. These approaches improved biosensor sensitivity above standard protocols for electrodes, receptor-guided biomarkers, and small molecule detection.…”

Section: Resultsmentioning

confidence: 99%

Peptide-Cellulose Conjugates on Cotton-Based Materials Have Protease Sensor/Sequestrant Activity

Edwards

Fontenot

Liebner

et al. 2018

Sensors

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The growing incidence of chronic wounds in the world population has prompted increased interest in chronic wound dressings with protease-modulating activity and protease point of care sensors to treat and enable monitoring of elevated protease-based wound pathology. However, the overall design features needed for the combination of a chronic wound dressing that lowers protease activity along with protease detection capability as a single platform for semi-occlusive dressings has scarcely been addressed. The interface of dressing and sensor specific properties (porosity, permeability, moisture uptake properties, specific surface area, surface charge, and detection) relative to sensor bioactivity and protease sequestrant performance is explored here. Measurement of the material’s zeta potential demonstrated a correlation between negative charge and the ability of materials to bind positively charged Human Neutrophil Elastase. Peptide-cellulose conjugates as protease substrates prepared on a nanocellulosic aerogel were assessed for their compatibility with chronic wound dressing design. The porosity, wettability and absorption capacity of the nanocellulosic aerogel were consistent with values observed for semi-occlusive chronic wound dressing designs. The relationship of properties that effect dressing functionality and performance as well as impact sensor sensitivity are discussed in the context of the enzyme kinetics. The sensor sensitivity of the aerogel-based sensor is contrasted with current clinical studies on elastase. Taken together, comparative analysis of the influence of molecular features on the physical properties of three forms of cellulosic transducer surfaces provides a meaningful assessment of the interface compatibility of cellulose-based sensors and corresponding protease sequestrant materials for potential use in chronic wound sensor/dressing design platforms.

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Section: Resultsmentioning

confidence: 99%

Peptide-Cellulose Conjugates on Cotton-Based Materials Have Protease Sensor/Sequestrant Activity

Edwards

Fontenot

Liebner

et al. 2018

Sensors

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“…Despite not being able to fully resolve the electrochemical processes for devices such as energy-storage or sensors, [8] these calculations could be useful for predicting boundary properties such as ion diffusion and double-layer morphology in the presence of an electric field to study the electrochemical reactions more in depth. Although not always reported, surface modifications were likely to occur.…”

Section: Can Computational Modeling and Advances In Mgns Help On Unramentioning

confidence: 99%

“…[4] In fact, many studies have shown that with reduction in size, nanomaterials display novel electrical, mechanical, chemical and optical properties, which are largely believed to be the result of surface and quantum confinement effects. [4,5] Remarkably, this trend has found traction in the metallic glass field where metallic glasses nanostructures (MGNs) demonstrate an important role in many applications such as light harvesting, [6] photovoltaic, [7] biomedical, [8] magneto-optical, [9] organic synthesis, [10] lithium-ion batteries [11] and electrocatalysis. [12] Recently, MGNs are receiving increased attention due to their distinguished performance, such as high activity and long term stability in electrocatalytic reactions.…”

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confidence: 99%

Recent Advances in Metallic Glass Nanostructures: Synthesis Strategies and Electrocatalytic Applications

Doubek

McMillon‐Brown

et al. 2018

Advanced Materials

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transformers [2] and load bearing applications. [3] In the last few decades, the study of nanomaterials has become a central focus in nanoscience and nanotechnology. [4] In fact, many studies have shown that with reduction in size, nanomaterials display novel electrical, mechanical, chemical and optical properties, which are largely believed to be the result of surface and quantum confinement effects. [4,5] Remarkably, this trend has found traction in the metallic glass field where metallic glasses nanostructures (MGNs) demonstrate an important role in many applications such as light harvesting, [6] photovoltaic, [7] biomedical, [8] magneto-optical, [9] organic synthesis, [10] lithium-ion batteries [11] and electrocatalysis. [12] Recently, MGNs are receiving increased attention due to their distinguished performance, such as high activity and long term stability in electrocatalytic reactions. [12,13] Although several review papers have already covered the topic of nanopatterning of bulk metallic glasses (BMGs), [14][15][16] the correlation between recent synthetic methods and electrocatalytic applications for MGNs has not been thoroughly addressed. Moreover, there is currently no review that unites MGNs synthesized from different approaches (top-down and bottom-up) with conventional electrochemical reactions. Therefore, in this review our mission is to: 1) present a focused perspective on the latest fabrication techniques of MGNs toward the pursuit of novel electrocatalysts and electrodes; 2) highlight recent advances in computational screening and predictions that could be applied toward new metallic glass electrocatalyst discovery; and 3) report distinct advancements in electrocatalytic applications related to MGNs by creating a comprehensive discussion for commonly employed kinetic parameters and their connection with the unique material structure. Finally, as the first progress report on the metallic glass based electrocatalysts, we will also highlight some of the challenges that need to be addressed toward future progress in this field.BMGs are those metallic glasses (MGs) that can be made in 'bulk' scale with good glass forming abilities, [17] representing a versatile platform for many applications. To date, a wide range of BMG-forming alloys have been developed, including Zr-, [18] Fe-, [19] Cu-, [20] Ni-, [21] Ti-, [22] Mg-, [23] Pd-, [24] Au-, [25] and Pt-based compositions. [26] Moreover, the increased disorder brought by the higher degree of multinary systems is believed to contribute to improving the glass formation. [27] The evolution to multicomponent alloys of the most recent MG studies has also made them natural candidates for catalysis. The amorphous multinary Recent advances in metallic glass nanostructures (MGNs) are reported, covering a wide array of synthesis strategies, computational discovery, and design solutions that provide insight into distinct electrocatalytic applications. A brief introduction to the development and unique features of MGNs with an overview of top-down and bottom-up sy...

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“…using platinum‐based BMGs to enhance the signal and sensitivity compared to planar electrodes, for the detection of glucose. [ 62 ]…”

Section: Materials Selection For Ec Biosensor Electrode Transducersmentioning

confidence: 99%

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

Elbadawi

Ong

Pollard

et al. 2020

Adv Funct Materials

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With the impending Industrial Revolution 4.0, the information produced by sensors will be central in many applications. This includes the healthcare sector, where affordable healthcare and precision medicine are highly sought after. Electrochemical sensors have the potential to produce affordable, high sensitivity and specificity, intuitive, and rapid point‐of‐care diagnostics. Underpinning these achievements is the choice of material and the fabrication thereof. In this review, the different types of materials used in electrochemical biosensors are reported, with a focus on synthetic conductive materials. The review demonstrates that there is an abundance of materials to select from, and compositing different types of materials further widens their applicability in biosensors. In addition, the fabrication of such materials using the state‐of‐the‐art of fabrication technology, additive manufacturing (AM), is also detailed. The need for compositing is evident in AM, as the feedstock for certain AM technologies is inherently nonconductive. Both material choice and fabrication technologies limitations are also discussed to highlight opportunities for growth. The review highlights how recent technological advancements have the potential to drive the healthcare industry toward achieving its primary goals.

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Nanopatterned Bulk Metallic Glass Biosensors

Cited by 27 publications

References 40 publications

Peptide-Cellulose Conjugates on Cotton-Based Materials Have Protease Sensor/Sequestrant Activity

Peptide-Cellulose Conjugates on Cotton-Based Materials Have Protease Sensor/Sequestrant Activity

Recent Advances in Metallic Glass Nanostructures: Synthesis Strategies and Electrocatalytic Applications

Additive Manufacturable Materials for Electrochemical Biosensor Electrodes

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