Nanoparticulated magnetic drug delivery systems: Preparation and magnetic characterization

Morais, P.C.

doi:10.1088/1742-6596/217/1/012091

Cited by 1 publication

(2 citation statements)

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“…In this context, particular interest is on nanometer-sized particles of iron oxide that allow combination of cancer therapy with their in vivo degradation into non-toxic iron ions. 7 MNPs showing superparamagnetic (SPM) behavior have indeed demonstrated their potential in anticancer drug delivery. 13−18 Magnetite (Fe 3 O 4 ) is a promising candidate as drug delivery medium owing to low toxicity and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…The growing interest in magnetic nanoparticles (MNPs) is mainly due to their versatility in a wide number of applicative fields, such as removal of toxic elements from industrial wastes, − magnetic resonance imaging (MRI) techniques for cancer diagnosis, and cancer therapy. − Integration of imaging-diagnostic systems based on positron emission tomography (PET) and MRI in a single diagnostic device PET/MRI (up to now the more advanced medical diagnostic instrumentation) moreover requires an effort on advanced material, instrumentation studies, and quality control. − The main advantage of using MNPs in biomedical field is due to the possibility to guide the drug to the target by means of an external magnetic field. In this context, particular interest is on nanometer-sized particles of iron oxide that allow combination of cancer therapy with their in vivo degradation into non-toxic iron ions . MNPs showing superparamagnetic (SPM) behavior have indeed demonstrated their potential in anticancer drug delivery. − …”

Section: Introductionmentioning

confidence: 99%

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Magnetic Nanoparticles Coated with (R)-9-Acetoxystearic Acid for Biomedical Applications

et al. 2020

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The well-known ability to selectively drive nanomagnetic materials coated with anticancer drugs into tumor cells suggested the synthesis and the characterization of magnetic nanoparticles (MNPs) functionalized with (R)-9-acetoxystearic acid, the acetic ester of (R)-9-hydroxystearic acid (9-HSA), an antiproliferative agent active against different cancer cells. The acyl chloride of (R)-9-acetoxystearic acid, synthesized in two steps from 9-HSA, was reacted with (3-aminopropyl)triethoxysilane, chosen as a linker between MNPs and the stearyl moiety. In the last step, the novel amide was bound to magnetite NPs by reaction with silyl groups. A detailed structural, chemical, and magnetic characterization of the obtained material proved that it possesses properties in agreement with the requirements for drug delivery, opening the possibility to further insights focused on the 9-HSA biomedical applications.

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Section: Introductionmentioning

confidence: 99%