Nanoparticulate Systems for Growth Factor Delivery

Zhang, Sufeng; Uludağ, Hasan

doi:10.1007/s11095-009-9897-z

Cited by 171 publications

(159 citation statements)

References 130 publications

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“…GFs are endogenous polypeptides that act through the cell-surface receptors to regulate cellular activities such as proliferation, migration and differentiation [155]. The outcome of GF therapeutics mainly depends on their delivery mode due to their rapid clearance in vivo [156]. Furthermore, one of the main challenges in TE is to find the best way to induce the correct differentiation of stem cells.…”

Section: Growth/differentiation Factor Deliverymentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

319

217

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Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

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Section: Growth/differentiation Factor Deliverymentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

319

217

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“…24 CNT, a water-soluble peptide, can change the distribution of negative and positive charges of polarity zones via ion-dipole interaction on the surface of the nanocapsules and hinder the aggregation and formation of larger particles. 25 The average size of CNT nanocapsules is smaller than blank nanocapsules due to interfacial interaction between CNT and lecithin. The positive charge of CNT can attract the negative charge of lecithin, making the nanocapsules compact and small.…”

Section: Results and Discussion Characteristics Of The Cnt Nanocapsulesmentioning

confidence: 99%

Photoresponsive nanocapsulation of cobra neurotoxin and enhancement of its central analgesic effects under red light

Yang

Zhao

et al. 2017

IJN

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Cobra neurotoxin (CNT), a peptide isolated from snake venom of Naja naja atra , shows central analgesic effects in our previous research. In order to help CNT pass through blood–brain barrier (BBB) and improve its central analgesic effects, a new kind of CNT nanocapsules were prepared by double emulsification with soybean lecithin and cholesterol as the shell, and pheophorbide as the photosensitizer added to make it photoresponsive. The analgesic effects were evaluated by hot plate test and acetic acid-induced writhing in mice. The CNT nanocapsules had an average particle size of 229.55 nm, zeta potential of −53.00 mV, encapsulation efficiency of 84.81% and drug loading of 2.98%, when the pheophorbide content was 1% of lecithin weight. Pheophorbide was mainly distributed in outer layer of the CNT nanocapsules and increased the release of the CNT nanocapsules after 650 nm illumination. The central analgesic effects were improved after intraperitoneal injection of CNT at 25 and 50 µg·kg −1 under 650 nm irradiation for 30 min in the nasal cavity. Activation of pheophorbide by red light generated reactive oxygen species which opened the nanocapsules and BBB and helped the CNT enter the brain. This research provides a new drug delivery for treatment of central pain.

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“…8,9 Nanotechnologies like nanoparticles or nanoreservoirs have also been introduced for the bioactivation of the scaffolds through the controlled release of bioactive therapeutics. [10][11][12][13][14][15] During the consolidation of a fracture, or during the continuous physiological bone remodeling, bone regeneration takes place. Medical applications for tissue-engineered (TE) bone implants can be divided into four categories.…”

Section: Introductionmentioning

confidence: 99%