Nanoparticles vs Cancer: A Multifuncional Tool

Sánchez‐Domínguez, Celia Nohemí; Gallardo‐Blanco, Hugo L.; Rodríguez-Rodríguez, Arturo; Vela-Gonzalez, Andrea V.; Sánchez-Domínguez, Margarita

doi:10.2174/1568026614666140118213316

Cited by 7 publications

(9 citation statements)

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“…However, synthesis of nanoparticles with an emphasis on the use of self-assembled systems such as micelles, microemulsions, nanoemulsions, and liposomes can increase the drug distribution, bioavailability, and its targeted action [258]. Thus, for better chemotherapeutics liposomal drug carriers are used for controlled release of active drug formulations at a predetermined rate.…”

Section: Drug Delivery Methodsmentioning

confidence: 99%

“…Further, anticancer drugs are designed that work with mild hyperthermia-mediated triggering and tumor-specific delivery. Hence, thermosensitive liposomes [258] are made by using thermosensitive polymers [259]. Further, targeted and ultrasound triggered drug delivery systems are made in which liposomes are comodified with cancer cell-targeting aptamers and thermosensitive polymers [259].…”

Section: Drug Delivery Methodsmentioning

confidence: 99%

“…However, liposomal nanoparticles are proved to be multifunctional tools [258] to carry various drugs for cancer therapy. These liposomal siRNA nanocarriers are also used in tumor therapy [239, 246] while enhanced endosomal/lysosomal escape by diesteryl phosphoethanolamine-polycarboxybetaine lipid is used for systemic delivery of siRNA [294].…”

Section: Drug Delivery Methodsmentioning

confidence: 99%

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Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

Upadhyay

2014

BioMed Research International

317

222

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Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB) for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs, radiopharmaceuticals, proteins, immunoglobulins, and chimeric peptides to the target sites in deep tissue locations inside tumor sites of brain has been explained. In addition, therapeutic applications of various types of nanoparticles such as chitosan based nanomers, dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers, cholesterol mediated cationic solid lipid nanoparticles, colloidal drug carriers, liposomes, and micelles have been discussed with their recent advancements. Emphasis has been given on the need of physiological and therapeutic optimization of existing drug delivery methods and their carriers to deliver therapeutic amount of drug into the brain for treatment of various neurological diseases and disorders. Further, strong recommendations are being made to develop nanosized drug carriers/vehicles and noninvasive therapeutic alternatives of conventional methods for better therapeutics of CNS related diseases. Hence, there is an urgent need to design nontoxic biocompatible drugs and develop noninvasive delivery methods to check posttreatment clinical fatalities in neuropatients which occur due to existing highly toxic invasive drugs and treatment methods.

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Section: Drug Delivery Methodsmentioning

confidence: 99%

Section: Drug Delivery Methodsmentioning

confidence: 99%

Section: Drug Delivery Methodsmentioning

confidence: 99%

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Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

Upadhyay

2014

BioMed Research International

317

222

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“…Different chemical, physical and biological characteristics, unique in nanoparticles, can be controlled during their synthesis to be used in biomedical applications. These physicochemical properties such as size, shape, surface charge, hydrophilic interactions, magnetism, and electrical characteristics as well as the lack of ability to produce an undesirable immunological reaction, make nanoparticles a promising tool in medicine (6). A special condition that makes nanotechnology so attractive for medicine is the capacity to target the therapy directly to the cancerous tissue without affecting healthy tissues, avoiding side effects.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for death‑induced gene therapy in cancer (Review)

et al. 2017

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Due to the high toxicity and side effects of the use of traditional chemotherapy in cancer, scientists are working on the development of alternative therapeutic technologies. An example of this is the use of death‑induced gene therapy. This therapy consists of the killing of tumor cells via transfection with plasmid DNA (pDNA) that contains a gene which produces a protein that results in the apoptosis of cancerous cells. The cell death is caused by the direct activation of apoptosis (apoptosis‑induced gene therapy) or by the protein toxic effects (toxin‑induced gene therapy). The introduction of pDNA into the tumor cells has been a challenge for the development of this therapy. The most recent implementation of gene vectors is the use of polymeric or inorganic nanoparticles, which have biological and physicochemical properties (shape, size, surface charge, water interaction and biodegradation rate) that allow them to carry the pDNA into the tumor cell. Furthermore, nanoparticles may be functionalized with specific molecules for the recognition of molecular markers on the surface of tumor cells. The binding between the nanoparticle and the tumor cell induces specific endocytosis, avoiding toxicity in healthy cells. Currently, there are no clinical protocols approved for the use of nanoparticles in death‑induced gene therapy. There are still various challenges in the design of the perfect transfection vector, however nanoparticles have been demonstrated to be a suitable candidate. This review describes the role of nanoparticles used for pDNA transfection and key aspects for their use in death‑induced gene therapy.

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“…[11][12][13] However, their performance is significantly limited by their fast photobleaching. [15][16][17][18] Chu et al conjugated aptamers to QDs through biotin-streptavidin system, and specifically recognized prostate tumor cells. [15][16][17][18] Chu et al conjugated aptamers to QDs through biotin-streptavidin system, and specifically recognized prostate tumor cells.…”

Section: Introductionmentioning

confidence: 99%

A recognition-before-labeling strategy for sensitive detection of lung cancer cells with a quantum dot–aptamer complex

Liu

Zhang

et al. 2015

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A highly specific recognition-before-labeling strategy has been developed for sensitive detection of non-small cell lung cancer A549 cells, by using fluorescent QDs as signal units and DNA aptamers as recognition elements. A QD-aptamer system used for cell imaging and bioanalysis mostly relies on the recognition-after-labeling strategy in which aptamers were firstly labeled with QDs and then the QD-aptamer conjugates as a whole were utilized for specific recognition. Here in our strategy, aptamers were used firstly to recognize target cells, and then fluorescent QDs were sequentially added to bind the aptamers and light the target cells. The proposed recognition-before-labeling strategy didn't require the complex process of QD functionalization, and avoided the possible impact on the aptamer configuration from steric hindrance. Meanwhile, QDs, with strong fluorescence and good photostability, also give this method a high signal-to-background ratio (S/B). The recognition-before-labeling strategy is simple and sensitive, suggesting a new method for in vitro diagnostic assays of cancer cells.

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Nanoparticles vs Cancer: A Multifuncional Tool

Cited by 7 publications

References 0 publications

Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

Nanoparticles for death‑induced gene therapy in cancer (Review)

A recognition-before-labeling strategy for sensitive detection of lung cancer cells with a quantum dot–aptamer complex

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