Nanoparticles that communicate in vivo to amplify tumour targeting

Maltzahn, Geoffrey von; Park, Ji-Ho; Lin, Kevin Y.; Singh, Neetu; Schwöppe, Christian; Mesters, Rolf M.; Berdel, Wolfgang E.; Ruoslahti, Erkki; Sailor, Michael J.; Bhatia, Sangeeta N.

doi:10.1038/nmat3049

Cited by 463 publications

(386 citation statements)

References 36 publications

(23 reference statements)

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“…Their potential use in the field ranges from detection by imaging, labeling, or sensing [1][2][3][4][5] to treatment, including drug delivery and phototherapy [6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia

Kodiha

Hutter

Boridy

et al. 2014

Cell. Mol. Life Sci.

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nanospheres, damaged the nucleus at normal growth temperature, several of these defects were further exacerbated by mild hyperthermia. Taken together, the toxicity of gold nanoparticles correlated with changes in nuclear organization and function. These results emphasize that the cell nucleus is a prominent target for gold nanoparticles of different morphologies. Moreover, we demonstrated that RNA synthesis in nucleoli provides quantitative information on nuclear damage and cancer cell survival.

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Section: Introductionmentioning

confidence: 99%

Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia

Kodiha

Hutter

Boridy

et al. 2014

Cell. Mol. Life Sci.

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“…This can be achieved through passive or active targeting mechanisms: passive targeting is enabled by enhanced vascular permeability during neoangiogenesis of injured or pathological body sites, while active targeting benefits from overexpression in the infectious or damaged areas of several cell surface molecules that can bind specifically to precoated nanoparticle ligands [58,59]. Recently, a dual modular system that mimics the communication-dependent recruitment of inflammatory cells to regions of disease has been developed to improve the tissue target efficiency of nanoparticles [60]. Another more recent study has demonstrated the programming and assembly of DNA-based nanorobots that are able to carry molecular loads, transport chemical ingredients to target cells and stimulate their intracellular alterations [61].…”

Section: Nanomedicine: a Giant Leap Forward In Disease Diagnosis And Trmentioning

confidence: 99%

Nanodentistry: Combining Nanostructured Materials and Stem Cells for Dental Tissue Regeneration

2012

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Regenerative dentistry represents an attractive multidisciplinary therapeutic approach that complements traditional restorative/surgery techniques and benefits from recent advances in stem cell biology, molecular biology, genomics and proteomics. Materials science is important in such advances to move regenerative dentistry from the laboratory to the clinic. The design of novel nanostructured materials, such as biomimetic matrices and scaffolds for controlling cell fate and differentiation, and nanoparticles for diagnostics, imaging and targeted treatment, is needed. The combination of nanotechnology, which allows the creation of sophisticated materials with exquisite fine structural detail, and stem cell biology turns out to be increasingly useful in regenerative medicine. The administration to patients of dynamic biological agents comprising stem cells, bioactive scaffolds and/or nanoparticles will certainly increase the regenerative impact of dental pathological tissues. This overview briefly describes some of the actual benefits and future possibilities of nanomaterials in the emerging field of stem cell-based regenerative dentistry.

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“…For example, tumor targeting, imaging and drug delivery were performed with sequentially administrated gold nanorods, iron oxide nanoworms and drug loaded liposomes [142]. Gold nanorods bound to tumor vessels converted electromagnetic energy into heat, which triggered a blood coagulation cascades.…”

Section: Nanoparticles For Combined Imaging and Therapymentioning

confidence: 99%

Engineering imaging probes and molecular machines for nanomedicine

Tong

Cradick

et al. 2012

Sci. China Life Sci.

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Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Due to the size-compatibility of nano-scale structures and devices with proteins and nucleic acids, the design, synthesis and application of nanoprobes, nanocarriers and nanomachines provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection, therapy, and prevention. Recent advances in nanomedicine include the development of functional nanoparticle based molecular imaging probes, nano-structured materials as drug/gene carriers for in vivo delivery, and engineered molecular machines for treating single-gene disorders. This review focuses on the development of molecular imaging probes and engineered nucleases for nanomedicine, including quantum dot bioconjugates, quantum dot-fluorescent protein FRET probes, molecular beacons, magnetic and gold nanoparticle based imaging contrast agents, and the design and validation of zinc finger nucleases (ZFNs) and TAL effector nucleases (TALENs) for gene targeting. The challenges in translating nanomedicine approaches to clinical applications are discussed. Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, biology, and medicine [1]. It focuses on the development of engineered nano-scale (1100 nm) materials, structures and devices for better diagnostics and highly specific medical intervention in curing disease or repairing damaged tissues. As a basis for nanomedicine, nanotechnology is the science, engineering, and technology related to the understanding and control of matter at the nano-scale, and the development of materials, devices, and systems that have novel properties and functions due to their nano-scale dimensions or components. Nanotechnology also provides new abilities to measure, control and manipulate matter (including soft matter) at the nano-scale what was unthinkable with conventional tools. Owing to the size-compatibility of nano-scale structures with proteins and nucleic acids in living cells, nanomedicine approaches have the potential to provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection, therapy, and prevention, thus revolutionizing medicine. Over the last ten years or so, significant efforts have been made in the US, China, Europe and elsewhere to develop nanomedicine. For example, the US National Institutes of Health has developed a nanomedicine centers network, and invested a significant amount of research funding to nanomedicine development. Just in FY 2009 (Oct. 1, 2008Sept. 30, 2009, the total NIH funding in nanotechnology/ nanoscience projects was more than 410 million US dollars. SPECIAL TOPIC

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Nanoparticles that communicate in vivo to amplify tumour targeting

Cited by 463 publications

References 36 publications

Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia

Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia

Nanodentistry: Combining Nanostructured Materials and Stem Cells for Dental Tissue Regeneration

Engineering imaging probes and molecular machines for nanomedicine

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