Nanoparticles retard immune cells recruitment in vivo by inhibiting chemokine expression

Xu, Jianxiong; Wang, Jinxuan; Qiu, Juhui; Liu, Hua; Wang, Yi; Cui, Yuliang; Humphry, Rose; Wang, Nan; Durkan, Colm; Chen, Yaokai; Lu, Yanqiu; Ma, Qinfeng; Wu, Wei; Luo, Yang; Xiao, Lehui; Wang, Guixue

doi:10.1016/j.biomaterials.2020.120392

Cited by 23 publications

(12 citation statements)

References 65 publications

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“…These bene cial properties have resulted in the widespread use of polymer nanoparticles as drug delivery systems and diagnostic contrast agents for medical applications. Despite their good biocompatibility, there are also disadvantages of polymer biomaterials in nano scale, especially under pathological conditions and the interactions of NPs with living cells are complex and still far from fully understood [35] .This article focuses on polymer nanoparticles and explores their impact on the development of cardiovascular diseases such as AS and possible mechanisms of function.…”

Section: Discussionmentioning

confidence: 99%

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice 

Yin

Atik

et al. 2020

Preprint

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The unique physiochemical properties of nanomaterials have been widely used in drug delivery systems and diagnostic contrast agents. The safety issues of biomaterials with exceptional biocompatibility and hemo-compatibility have also received extensive attention at the nanoscale, especially in cardiovascular disease. Therefore, we conducted a study of the effects of poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) on the development of aortic atherosclerotic plaques in ApoE-/- mice. The particle size of PLGA NPs was 92.69 ± 3.1 nm and the zeta potential were -31.6 ± 2.8 mV, with good blood compatibility. ApoE-/- mice were continuously injected with PLGA NPs intravenously for 4 and 12 weeks. Examination of oil red O stained aortic sinuses confirmed that the accumulation of PLGA NPs promoted the formation of atherosclerotic plaques and increasing the expression of associated inflammatory factors, such as TNF-α, IL-6, and IL-10. The combined exposure of ox-LDL and PLGA NPs accelerated the conversion of macrophages to foam cells. Our results highlight the potential risk for PLGA NPs in vivo and further understanding the interaction between PLGA NPs and the atherosclerotic plaques, which we should consider in future nanomaterial design and pay more attention to the process of using nano-medicines on cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice 

Yin

Atik

et al. 2020

Preprint

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“…Additionally, the Au NPs did not induce ROS [ 151 ]. Gold NPs were found to decrease cytokine expression and reduce the gene expression of chemokine receptors in THP-1 cells, as well as to slow the recruitment of immune cells to a wound in male C57BL/6 mice that had been irradiated to destroy their own immune cells and then transplanted with Au NP treated macrophages [ 152 ].…”

Section: Inflammatory and Anti-inflammatory Effects Of Nanoparticlesmentioning

confidence: 99%

“…Released cytokines and other inflammatory mediators function as soluble intercellular messengers to communicate with and recruit other immune cells and thus are integral in regulating inflammation and the immune response [119,141,142]. Many studies have found that various NPs induce an increase in both gene and/or protein expression of pro-inflammatory cytokines [25,98,117,131,134,136,137,[143][144][145][146][147][148], while other NPs have been found to be antiinflammatory [136,[149][150][151][152][153][154][155][156]. The transcription factor NF-κB has a central role in regulating the production of pro-inflammatory cytokines such as TNF-α, IL-8, IL-2, and IL-6, while MAPKs are involved in regulating the production of pro-inflammatory cytokines such as TNF-α, IL-1, IL-6, IL-8, and MCP-1 [101,157].…”

Section: Inflammatory and Anti-inflammatory Effects Of Nanoparticlesmentioning

confidence: 99%

Nanoparticle Effects on Stress Response Pathways and Nanoparticle–Protein Interactions

Cameron

Sheng

Hosseinian

et al. 2022

IJMS

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Nanoparticles (NPs) are increasingly used in a wide variety of applications and products; however, NPs may affect stress response pathways and interact with proteins in biological systems. This review article will provide an overview of the beneficial and detrimental effects of NPs on stress response pathways with a focus on NP–protein interactions. Depending upon the particular NP, experimental model system, and dose and exposure conditions, the introduction of NPs may have either positive or negative effects. Cellular processes such as the development of oxidative stress, the initiation of the inflammatory response, mitochondrial function, detoxification, and alterations to signaling pathways are all affected by the introduction of NPs. In terms of tissue-specific effects, the local microenvironment can have a profound effect on whether an NP is beneficial or harmful to cells. Interactions of NPs with metal-binding proteins (zinc, copper, iron and calcium) affect both their structure and function. This review will provide insights into the current knowledge of protein-based nanotoxicology and closely examines the targets of specific NPs.

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“…Macrophages/monocytes, as an important member of immune system, can be recruited to the injured site as soon as 15 min [ 54 ], and differentiate into pro-inflammatory M1 and anti-inflammatory M2 macrophages according to the injured degree and type of the injured location [ 137 ]; whereas uncontrivable M1 macrophages in cardiovascular will exacerbate a variety of inflammation-based disorders, such as atherosclerosis, MI, intimal hyperplasia and so on [ 11 , 18 ]. During myocardial I/R or other vascular injured diseases, abnormally accumulating M1 macrophages will result in inflammation and a disturbing reparative stage.…”

Section: The Bioengineered Strategies For Evs To Target Vascular Inju...mentioning

confidence: 99%

Recent advances of natural and bioengineered extracellular vesicles and their application in vascular regeneration

Wang

Chen

et al. 2022

Regenerative Biomaterials

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The progression of cardiovascular diseases such as atherosclerosis and myocardial infarction leads to serious vascular injury, highlighting the urgent need for targeted regenerative therapy. Extracellular vesicles (EVs) composed of a lipid bilayer containing nuclear and cytosolic materials are relevant to the progression of cardiovascular diseases. Moreover, EVs from multiple cells will deliver bioactive cargo in pathological cardiovascular and regulate the biological function of recipient cells, such as inflammation, proliferation, angiogenesis, and polarization. However, because the targeting and bioactivity of natural EVs are subject to several limitations, bioengineered EVs have achieved wide advancements in biomedicine. Bioengineered EVs involve three main ways to acquire including 1) Modification of the EVs after isolation; 2) Modification of producer cells before EVs’ isolation; 3) Synthesize EVs using natural or modified cell membranes, and encapsulating drugs or bioactive molecules into EVs. In this review, we firstly summarize the cardiovascular injury-related disease and describe the role of different cells and EVs in vascular regeneration. We also discuss the application of bioengineered EVs from different producer cells to cardiovascular diseases. Finally, we summarize the molecular that can be modified in EVs to specifically target abnormal cells in injured vascular.

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Nanoparticles retard immune cells recruitment in vivo by inhibiting chemokine expression

Cited by 23 publications

References 65 publications

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice

Nanoparticle Effects on Stress Response Pathways and Nanoparticle–Protein Interactions

Recent advances of natural and bioengineered extracellular vesicles and their application in vascular regeneration

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Nanoparticles retard immune cells recruitment in vivo by inhibiting chemokine expression

Cited by 23 publications

References 65 publications

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice&nbsp;

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice&nbsp;

Nanoparticle Effects on Stress Response Pathways and Nanoparticle–Protein Interactions

Recent advances of natural and bioengineered extracellular vesicles and their application in vascular regeneration

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Product

Resources

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Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice