Nanoparticles of Poorly Water-Soluble Drugs Prepared by Supercritical Fluid Extraction of Emulsions

Shekunov, Boris Y.; Chattopadhyay, Pratibhash; Seitzinger, Jeff; Huff, Robert

doi:10.1007/s11095-005-8635-4

Cited by 146 publications

(102 citation statements)

References 16 publications

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“…According to several articles, regarding to supercritical fluid extraction of emulsion technology, there is a significant correlation between the droplet size in initial emulsion and the final particle size distribution [19,17]. Thus, as a preliminary study, in the first set of the experiments the main process parameters analysed were those expected to influence the properties of the initial emulsion: quercetin concentration (0.02 -0.04 w/w%), Pluronic L64…”

Section: Experimental Plans and Statistical Analysis Of Resultsmentioning

confidence: 99%

“…Meanwhile in the SAS antisolvent precipitation method particle nucleation and growth occur across the whole solution volume, in the case of SFEE the formation of particles is confined within the emulsion droplets. This restrains the size of the particles obtained, that can be one order of magnitude smaller than particles produced by solution precipitation [17].…”

Section: (Figure 1)mentioning

confidence: 99%

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Production of stabilized quercetin aqueous suspensions by supercritical fluid extraction of emulsions

Lévai

Martín

Paz

et al. 2015

The Journal of Supercritical Fluids

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Quercetin is a flavonoid with highly promising bioactivity against a variety of diseases, due to its strong antioxidant, antiviral and antihistaminic effect, but these applications are limited by the low solubility of quercetin in gastrointestinal fluids and the correspondingly low bioavailability. The objective of this work is to produce encapsulated quercetin particles in sub-micrometric scale, in order to increase their low bioavailability. These particles were produced by extraction of organic solvent from oil in water emulsions by Supercritical Fluid Extraction of Emulsions (SFEE). Due to the rapid extraction of organic solvent by this method, the disperse organic phase becomes rapidly supersaturated, causing the precipitation of quercetin particles in sub-micrometric scale, encapsulated by the surfactant material. Two different biopolymers (Pluronic L64 ® poloxamers and soy bean lecithin) were used as carriers and surfactant materials. In experiments with Pluronic, needle quercetin particles were obtained after SFEE treatment, with particle sizes around 1 µm and poor encapsulation efficiency. In case of soy lecithin, quercetin-loaded multivesicular liposomes were obtained, with a mean particle size around 100 nm and around 70% encapsulation efficiency of quercetin, without presence of segregated quercetin crystals.

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Section: Experimental Plans and Statistical Analysis Of Resultsmentioning

confidence: 99%

Section: (Figure 1)mentioning

confidence: 99%

Production of stabilized quercetin aqueous suspensions by supercritical fluid extraction of emulsions

Lévai

Martín

Paz

et al. 2015

The Journal of Supercritical Fluids

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“…The most important two are supercritical antisolvent precipitation (SAS) 163,164 and supercritical fluid extraction of emulsions (SFEE). 165,166 The fundamental mechanism of SAS is based on rapid precipitation when a drug solution is brought into contact with a supercritical CO 2 . SFEE is based on extraction of the organic phase in oil-in-water or multiple emulsions using supercritical CO 2 .…”

Section: Supercritical Fluid Technology (Scf)mentioning

confidence: 99%

“…SFEE is based on extraction of the organic phase in oil-in-water or multiple emulsions using supercritical CO 2 . 165,166 The schematic representation of SAS and SFEE processes is shown in Figure 5. Because most of the drugs (eg, asthma drugs) are not soluble in CO 2 , SAS processes provide an easy and excellent way to produce dry powder inhalation formulations.…”

Section: Supercritical Fluid Technology (Scf)mentioning

confidence: 99%

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

405

269

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“…A possible alternative is the use of compressed gases or supercritical fluids to remove the organic solvent from the emulsion in order to produce essential oil-loaded micelles, according to the Supercritical Extraction from Emulsions (SFEE) process [87]. A schematic diagram of this process is presented in Fig.…”

Section: Encapsulation In Micelles and Liposomesmentioning

confidence: 99%

Encapsulation and Co-Precipitation Processes with Supercritical Fluids: Applications with Essential Oils

Martín¹,

Varona²,

Navarrete³

et al. 2010

TOCENGJ

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Essential oils have important commercial applications as preservatives and flavours, and more recently as natural antimicrobial agents. These applications require a suitable formulation constituted by biodegradable compounds that protect the essential oil from degradation and evaporation at the same time that allows for a sustained release. Microcapsules of biopolymers loaded with essential oils meet these requirements. Such microcapsules can be prepared with different processes such as spray-drying, freeze-drying and coacervation, and supercritical fluids are an advantageous medium for this purpose. Some supercritical fluid-based precipitation processes have already been applied to produce these microcapsules. Amongst them, the results obtained with Particles from Gas Saturated Solutions (PGSS), PGSS-drying and Concentrated Powder Form (CPF) processes are particularly promising. Recent developments in the preparation of formulations with supercritical fluids include the preparation of liposomes and micelles, which can be suitable carriers for essential oils.

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Nanoparticles of Poorly Water-Soluble Drugs Prepared by Supercritical Fluid Extraction of Emulsions

Cited by 146 publications

References 16 publications

Production of stabilized quercetin aqueous suspensions by supercritical fluid extraction of emulsions

Production of stabilized quercetin aqueous suspensions by supercritical fluid extraction of emulsions

Nanomedicine in pulmonary delivery

Encapsulation and Co-Precipitation Processes with Supercritical Fluids: Applications with Essential Oils

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