Nanoparticles of Ni1−Cu  alloys for enhanced heating in magnetic hyperthermia

Araújo-Barbosa, S.; Morales, Marco A.

doi:10.1016/j.jallcom.2019.02.148

Cited by 20 publications

(10 citation statements)

References 51 publications

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“…The sizes of the NPs ranged between 11 and 20 nm. Magnetic moments increased (per unit cell) with increasing Ni concentration, and the samples had a specific loss power of up to 5.86 W/g at a low field and frequency, which indicated a promising efficiency for MH [99].…”

Section: Nicu Mnp Functionalization Methodsmentioning

confidence: 95%

“…Araújo-Barbosa et al [99] produced non-aggregated and monodispersed NiCu alloy NPs embedded in a chitosan matrix. A modified sol-gel method that included the use of the chitosan polymer prevented the particles from aggregating and favored the formation of particles with a narrow size distribution.…”

Section: Nicu Mnp Functionalization Methodsmentioning

confidence: 99%

“…As in the case of other superparamagnetic MNP investigations, most of the NiCu MNP research studies focused on MH applications [36][37][38][39][40]47,48,60,79,99]. In addition to the studies mentioned above, newer studies reported their potential use in bimodal cancer treatment formulations (e.g., a combination of MH and controlled drug delivery) [16], as part of medical implants [49,101], in formulations with antibacterial activity [102], and as part of dental materials [103].…”

Section: Application Of Nicu Mnps In Biomedicinementioning

confidence: 99%

“…The potential uses of NiCu MNPs in biomedicine are summarized in Figure 13. [60], Bimodal therapies [17], MH [37][38][39][40][41]48,49,96,98,99], Interstitial implants [50,100], Dental materials [101]. [60], Bimodal therapies [17], MH [37][38][39][40][41]48,49,96,98,99], Interstitial implants [50,100], Dental materials [101].…”

Section: Application Of Nicu Mnps In Biomedicinementioning

confidence: 99%

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The Potential Biomedical Application of NiCu Magnetic Nanoparticles

2019

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Magnetic nanoparticles became increasingly interesting in recent years as a result of their tailorable size-dependent properties, which enable their use in a wide range of applications. One of their emerging applications is biomedicine; in particular, bimetallic nickel/copper magnetic nanoparticles (NiCu MNPs) are gaining momentum as a consequence of their unique properties that are suitable for biomedicine. These characteristics include stability in various chemical environments, proven biocompatibility with various cell types, and tunable magnetic properties that can be adjusted by changing synthesis parameters. Despite the obvious potential of NiCu MNPs for biomedical applications, the general interest in their use for this purpose is rather low. Nevertheless, the steadily increasing annual number of related papers shows that increasingly more researchers in the biomedical field are studying this interesting formulation. As with other MNPs, NiCu-based formulations were examined for their application in magnetic hyperthermia (MH) as one of their main potential uses in clinics. MH is a treatment method in which cancer tissue is selectively heated through the localization of MNPs at the target site in an alternating magnetic field (AMF). This heating destroys cancer cells only since they are less equipped to withstand temperatures above 43 °C, whereas this temperature is not critical for healthy tissue. Superparamagnetic particles (e.g., NiCu MNPs) generate heat by relaxation losses under an AMF. In addition to MH in cancer treatment, which might be their most beneficial potential use in biomedicine, the properties of NiCu MNPs can be leveraged for several other applications, such as controlled drug delivery and prolonged localization at a desired target site in the body. After a short introduction that covers the general properties of NiCu MNPs, this review explores different synthesis methods, along with their main advantages and disadvantages, potential surface modification approaches, and their potential in biomedical applications, such as MH, multimodal cancer therapy, MH implants, antibacterial activity, and dentistry.

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Section: Nicu Mnp Functionalization Methodsmentioning

confidence: 95%

Section: Nicu Mnp Functionalization Methodsmentioning

confidence: 99%

Section: Application Of Nicu Mnps In Biomedicinementioning

confidence: 99%

Section: Application Of Nicu Mnps In Biomedicinementioning

confidence: 99%

See 2 more Smart Citations

The Potential Biomedical Application of NiCu Magnetic Nanoparticles

2019

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“…Many trials were performed to optimize some or all of those factors using different methods of particle preparations [16,17]. Other work has been developed to enhance the particles dispersion and biocompatibility in biological solutions using thermal seed of alloys, iron oxides as colloidal mediators, and Ni-Cu nanoparticles [17][18][19][20][21][22][23]. Although there have been many works to optimize the heating power-related factors, nanoparticles still represent considerable technical challenges like the formation of clusters and agglomerates, which negatively affect the total output heating power [24,25].…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic Fe/Au Nanoparticles and Their Feasibility for Magnetic Hyperthermia

et al. 2021

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Today, magnetic hyperthermia constitutes a complementary way to cancer treatment. This article reports a promising aspect of magnetic hyperthermia addressing superparamagnetic and highly Fe/Au core-shell nanoparticles. Those nanoparticles were prepared using a wet chemical approach at room temperature. We found that the as-synthesized core shells assembled with spherical morphology, including face-centered-cubic Fe cores coated and Au shells. The high-resolution transmission microscope images (HRTEM) revealed the formation of Fe/Au core/shell nanoparticles. The magnetic properties of the samples showed hysteresis loops with coercivity (HC) close to zero, revealing superparamagnetic-like behavior at room temperature. The saturation magnetization (MS) has the value of 165 emu/g for the as-synthesized sample with a Fe:Au ratio of 2:1. We also studied the feasibility of those core-shell particles for magnetic hyperthermia using different frequencies and different applied alternating magnetic fields. The Fe/Au core-shell nanoparticles achieved a specific absorption rate of 50 W/g under applied alternating magnetic field with amplitude 400 Oe and 304 kHz frequency. Based on our findings, the samples can be used as a promising candidate for magnetic hyperthermia for cancer therapy.

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