Nanoparticles of lactoferrin for encapsulation of food ingredients

Bourbon, Ana I.; Martins, Joana T.; Pinheiro, Ana Cristina; Madalena, Daniel A.; Marques, Arlete Maria Lima; Nunes, Rafaela; Vicente, A. A.

doi:10.1016/b978-0-12-815663-6.00006-9

Cited by 8 publications

(11 citation statements)

References 102 publications

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“…Antimicrobial peptides have been previously proposed as biomarkers for brain infections involved in the AD developmental processes [ 151 ]. An example of such biomarkers is lactoferrin, a globular non-hemic iron-binding glycoprotein that belongs to the family of serum transferrin proteins, and it is mostly synthesized by glandular epithelial cells and neutrophils [ 159 , 160 , 161 , 162 ]. Owing to its iron-binding activity, lactoferrin is a multifunctional protein that exhibits antibacterial, antiviral, antifungal, antioxidant, immunomodulatory, anti-cancer, anti-inflammatory and anti-allergenic properties [ 160 , 162 , 163 , 164 ].…”

Section: Saliva Biomarkersmentioning

confidence: 99%

Body Fluid Biomarkers for Alzheimer’s Disease—An Up-To-Date Overview

2020

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Neurodegeneration is a highly complex process which is associated with a variety of molecular mechanisms related to ageing. Among neurodegenerative disorders, Alzheimer’s disease (AD) is the most common, affecting more than 45 million individuals. The underlying mechanisms involve amyloid plaques and neurofibrillary tangles (NFTs) deposition, which will subsequently lead to oxidative stress, chronic neuroinflammation, neuron dysfunction, and neurodegeneration. The current diagnosis methods are still limited in regard to the possibility of the accurate and early detection of the diseases. Therefore, research has shifted towards the identification of novel biomarkers and matrices as biomarker sources, beyond amyloid-β and tau protein levels within the cerebrospinal fluid (CSF), that could improve AD diagnosis. In this context, the aim of this paper is to provide an overview of both conventional and novel biomarkers for AD found within body fluids, including CSF, blood, saliva, urine, tears, and olfactory fluids.

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Section: Saliva Biomarkersmentioning

confidence: 99%

Body Fluid Biomarkers for Alzheimer’s Disease—An Up-To-Date Overview

2020

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“…Increased consumer demand for foods that promote nutrition and health encourages food manufacturers and researchers to innovate safe and cost-effective food that can provide multiple benefits in a single entity [ 69 ]. Consequently, bovine colostrum (BC) and its derivatives have attracted researchers to use their biologically active constituents to make functional food and feed supplements [ 28 ].…”

Section: Bovine Colostrum As Modern Deliverable Nutraceutical Formula...mentioning

confidence: 99%

“…The authors also suggested that purified IgG be added to infant formula, which could have protective effects in contrast to raw milk or colostrum and also be microbiologically safe. The BC antibodies showed positive results (in vitro) in the reduction in infection from bovine leukemia virus (BLV) in neonate calves [ 101 ], where BC-derived dietary exosomes encourage antiosteoporosis activity in vivo and in vitro [ 69 ]. The IgG from bovines assists in the modulation of intestinal cells and increases the adherence of bifidobacteria [ 102 ].…”

Section: Current Evidence Of Therapeutic Use Of Bcmentioning

confidence: 99%

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements

et al. 2022

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Bovine colostrum (BC) is the initial mammary secretion after parturition, which is nature’s bountiful source consisting of nutritional and bioactive components present in a highly concentrated low-volume format. All mammalian newborns require colostrum to enhance physiological processes such as lifelong immunity, gastrointestinal development, and resistance to microbial infections. The genetic, environmental, and processing methods can all have an impact on the biochemical contents of BC and its supplements. BC and its derivatives have been intensively researched for their potential use in functional foods, medicines, and animal feed. Evidence from clinical studies suggests that BC products are well-tolerated, nontoxic, and safe for human ingestion. Functional foods, feed, and pharmaceutical formulations based on bovine colostrum are playing noteworthy roles in the development of innovative products for promoting health and the prevention of chronic illnesses. This systematic review sheds light on recent research on (a) the effects of processing techniques on BC components, (b) emerging techniques used in the isolation and identification of novel components, (c) BC-based functional foods for human consumption and animal feed supplements, and (d) the role of BC in current drug delivery, as well as future recommendations.

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“…Lactoferrin (LF) is a multifunctional globular glycoprotein that can be characterized as a member of the transferrin family [1,2]. It is an iron-binding protein composed of a single-chain polypeptide with two globular lobes [3]. e polypeptide chain consists of approximately 600-700 amino acid residues and has a molecular weight of 80 kDa [4].…”

Section: Introductionmentioning

confidence: 99%

An Efficient Heparin Affinity Column Purification Method Coupled with Ultraperformance Liquid Chromatography for the Quantification of Native Lactoferrin in Breast Milk

Yuan

Xun³

et al. 2021

Journal of Food Quality

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Lactoferrin (LF) is a bioactive multifunctional protein and found in the highest amounts in human milk. Several methods can be used to quantify LF. However, quantification of native LF has garnered relatively little interest to date. This study aimed to develop a novel efficient two-step method for quantifying native LF in breast milk. During the analysis, LF was first extracted with phosphate buffer (pH 5.0), purified using a heparin affinity column. Subsequently, LF was detected using ultraperformance liquid chromatography (UPLC) at a wavelength of 201 nm. A linear calibration curve was obtained in the range of 5–200 mg/L. The limit of detection and limit of quantitation were 1 mg/L and 5 mg/L, respectively, indicating that the validated method could be employed to quantify LF in breast milk. Compared with previous HPLC methods, this method demonstrated several remarkable advantages, including simple operation, low-cost detection, and high accuracy. Hence, the results demonstrate an efficient method that can be employed commercially to purify and analyze LF in human milk samples.

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Nanoparticles of lactoferrin for encapsulation of food ingredients

Cited by 8 publications

References 102 publications

Body Fluid Biomarkers for Alzheimer’s Disease—An Up-To-Date Overview

Body Fluid Biomarkers for Alzheimer’s Disease—An Up-To-Date Overview

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements

An Efficient Heparin Affinity Column Purification Method Coupled with Ultraperformance Liquid Chromatography for the Quantification of Native Lactoferrin in Breast Milk

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