Nanoparticles of cerium dioxide – an effective antiviral agent and adjuvant of biologically active molecules

Shydlovska, Olga; Kharchenko, Eugene; Osenniy, Ivan; Spivak, Mykola; Shcherbakov, A. B.; Zholobak, Nadezhda

doi:10.15587/2519-8025.2018.124686

Cited by 9 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the pioneering work of Zholobak et al [ 116 ], demonstrating the antiviral ability of polymer-coated ceria nanoparticles, the antiviral/virucide properties of nanoceria have been studied intensively. Cerium oxide nanoparticles have been demonstrated to protect against the Herpes simplex virus 1 (HSV-1) in the RF cell line [ 117 ], and vesicular stomatitis Indiana virus (VSV) in L929 [ 116 , 117 ], EPT [ 116 ] and ST [ 118 ] cell lines. The activity of biogenic CeO 2 nanoparticles against the Sabin-like poliovirus has been reported recently [ 119 ].…”

Section: Ceria-containing Antibacterial and Antiviral Multifunctiomentioning

confidence: 99%

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

et al. 2021

View full text Add to dashboard Cite

The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

show abstract

Section: Ceria-containing Antibacterial and Antiviral Multifunctiomentioning

confidence: 99%

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…For example, the conjugation of noble metal NPs (Ag and Au) with the antiviral peptide FluPep was reported to enhance the inhibition of the Influenza virus compared to the peptide alone, which may be related to the high grafting density of the FluPep ligand on the surface of the NPs [33]. Cerium oxide (CeO 2 ) NPs were reported in link with Vesicular stomatitis virus [34] and in association with interferon to allow its prolonged effect in the treatment of Herpes [35]. Other particulate systems were also investigated.…”

Section: Nanocarriers Of Active Agentsmentioning

confidence: 99%

Nanotechnologies: A Key Role in Virus Fight

Drouet¹

2020

BJSTR

View full text Add to dashboard Cite

Zika, Ebola, Covid-19… Viruses from their nanoworld are at the origin of major health challenges and may cause pandemic threats. In the crusade for virus fight, being "small" may be an asset, for being active at the right scale. Nanosystems have recurrently been used to enhance the immune response of the body, by themselves or in combination with active agents (e.g. antigens) as well as for virus detection and isolation. This article is not an exhaustive review, but it envisions giving a general overview of the rationale behind the use of nanotechnology in virus fight, as illustrated by several significant examples including recent findings. Nanosystems, and in particular inorganic nanoparticles, offer a large variety of declinations that may be tailored in terms of physical and chemical characteristics to address the needs of virology. Among them, noble metals, metal oxides, mesoporous silica and calcium phosphates showed special promise. In particular, the bio-inspired character and modularity of calcium phosphates is appealing and allows envisioning further original developments in the fight against infections.

show abstract

“…It is also well known that cerium oxide nanoparticles mimic the activity of endogenous enzymes such as superoxide dismutase (SOD) [17][18][19] and catalase [20]. Cerium oxide nanoparticles are considered as a promising anticancer [21][22][23], antibacterial [24][25][26] and antiviral [27][28][29] agent as well as a promising inorganic antioxidant for diverse biomedical applications [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biocompatibility study of ceria-mildronate nanocomposite in vitro

Попов¹,

Kolmanovich²,

Popova³

et al. 2022

Nanosystems: Phys. Chem. Math.

View full text Add to dashboard Cite

Nanoscale cerium dioxide (CeO 2 , nanoceria) possesses notable redox activity, which is actively used in advanced biomedical applications. The low toxicity, high biocompatibility and antioxidant activity of nanoceria make it a new generation nanozyme with a unique activity. Combination of nanoceria with various biologically active substances results in organic-inorganic nanocomposites possessing enhanced activity. Here, we synthesized a novel organic-inorganic hybrid material (Mil-CeO 2 ) based on 2-(2-carboxylatoethyl)-1,1,1-trimethylhydrazinium and nanoceria, which has an ultra-small particle size, high antioxidant activity and pronounced biological activity. The analysis of cytotoxicity of the composite did not reveal any negative effects on the NCTC L929 mouse fibroblasts at concentrations below 10 mM. It was shown that the nanocomposite did not cause morphological changes in cells, or lead to cell death and mitochondrial membrane potential disruption, while maintaining viability in mouse fibroblasts in vitro. Additionally, we showed that Mil-CeO 2 is capable of protecting cells from hydrogen peroxide (H 2 O 2 )-induced or radiation-induced oxidative stress.

show abstract

Nanoparticles of cerium dioxide – an effective antiviral agent and adjuvant of biologically active molecules

Cited by 9 publications

References 5 publications

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

Nanotechnologies: A Key Role in Virus Fight

Synthesis and biocompatibility study of ceria-mildronate nanocomposite in vitro

Contact Info

Product

Resources

About