Nanoparticles: New agents toward treatment of leishmaniasis

Nafari, Amirhossein; Cheraghipour, Kourosh; Sepahvand, Maryam; Shahrokhi, Ghazal; Gabal, Esraa; Mahmoudvand, Hossein

doi:10.1016/j.parepi.2020.e00156

Cited by 74 publications

(38 citation statements)

References 81 publications

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“…Leishmaniasis is one of the most important infectious diseases in the world with 30,000 deaths annually 54 , which leads to the death by damaging macrophage cells, spleen, bone marrow, and liver. With the advancement of technology and the inadequacy of current therapeutic drugs, the application of nanostructures with unique properties and plant extracts with antimicrobial activities has recently attracted the attention of researchers 55 .…”

Section: Discussionmentioning

confidence: 99%

“…With the advancement of technology and the inadequacy of current therapeutic drugs, the application of nanostructures with unique properties and plant extracts with antimicrobial activities has recently attracted the attention of researchers 55 . Today, various nanostructures with different structures, suitable permeability, targeting properties, low toxicity, lack of resistance, high stability, and cost-effectiveness properties are widely deployed in the treatment of different diseases 54 , 56 . The transfer of amphotericin to glycine polymer-coated iron oxide nanoparticles could significantly reduce Leishmania parasite in the spleen 57 .…”

Section: Discussionmentioning

confidence: 99%

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Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications

Alijani

Iravani

Pourseyedi

et al. 2021

Sci Rep

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Greener methods for the synthesis of various nanostructures with well-organized characteristics and biomedical applicability have demonstrated several advantages, including simplicity, low toxicity, cost-effectiveness, and eco-friendliness. Spinel nickel ferrite (NiFe2O4) nanowhiskers with rod-like structures were synthesized using a simple and green method; these nanostructures were evaluated by X-ray diffraction analysis, transmission electron microscopy, scanning electron microscopy, and X-ray energy diffraction spectroscopy. Additionally, the prepared nanowhiskers could significantly reduce the survival of Leishmania major promastigotes, at a concentration of 500 μg/mL; the survival of promastigotes was reduced to ≃ 26%. According to the results obtained from MTT test (in vitro), it can be proposed that further studies should be conducted to evaluate anti-leishmaniasis activity of these types of nanowhiskers in animal models.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications

Alijani

Iravani

Pourseyedi

et al. 2021

Sci Rep

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“…Silver nanoparticles (nano-Ag) represent antimicrobial agents with unique properties that improve their biocompatibility because of their high ratio of surface area to volume, no charge, and nontoxicity to humans. Some studies show that nano-Ag interacts with membrane or cell wall, DNA, and proteins of microorganisms to produce the antimicrobial effect [56].…”

Section: Nanoparticle-based Treatment For Infectious Diseasesmentioning

confidence: 99%

Nanobiotechnology for the Detection and Control of Waterborne Parasites

Hikal¹,

Bratovčić²,

Baeshen³

et al. 2021

OJE

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Nowadays, the fast development of nanobiotechnology, has led to rapid diagnosis of important infectious diseases such as arboviruses-borne diseases, vector-borne infections and waterborne parasites diseases and others in order to reduce and avoid further dissemination of the infections within the general population. Furthermore, new nanomedicines based on the application of silver and gold nanoparticles which are less toxic, more effective, and that does not generate resistance could help to solve the problems of parasitic disease like leishmaniasis and chagas disease. It turns out that the combination of nanoparticles with antibiotics not only reduces the toxicity of both agents towards human cells but also enhances their ability to destroy bacteria by facilitating the binding of antibiotics to the microbes. Moreover, combining nanoparticles with antimicrobial peptides and essential oils with nanoparticles generates genuine synergy against microbial resistance.

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“…The benefits of encapsulation include increased solubility and bioavailability, protection against degradation, and the potential for modified release kinetics or targeting to specific sites in the body, thereby reducing toxicity of the compound of interest ( Banik et al., 2016 ; Barouti et al., 2017 ). This increase in bioavailability while limiting toxicity has resulted in improved safety profiles and efficacy of a multitude of anti- Leishmania compounds including liposomal AmB that is currently approved for clinical use ( Croft and Coombs, 2003 ; Nafari et al., 2020 ). Thus, it is likely that Retro-2 and SAR DHQZ analogs would greatly benefit from nanoparticle encapsulation to improve efficacy of these compounds through improved solubility and delivery.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections

Craig

Calarco²,

Conte³

et al. 2021

Front. Cell. Infect. Microbiol.

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Clinical manifestations of leishmaniasis range from self-healing, cutaneous lesions to fatal infections of the viscera. With no preventative Leishmania vaccine available, the frontline option against leishmaniasis is chemotherapy. Unfortunately, currently available anti-Leishmania drugs face several obstacles, including toxicity that limits dosing and emergent drug resistant strains in endemic regions. It is, therefore, imperative that more effective drug formulations with decreased toxicity profiles are developed. Previous studies had shown that 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide (also called Retro-2) has efficacy against Leishmania infections. Structure–activity relationship (SAR) analogs of Retro-2, using the dihydroquinazolinone (DHQZ) base structure, were subsequently described that are more efficacious than Retro-2. However, considering the hydrophobic nature of these compounds that limits their solubility and uptake, the current studies were initiated to determine whether the solubility of Retro-2 and its SAR analogs could be enhanced through encapsulation in amphiphilic polymer nanoparticles. We evaluated encapsulation of these compounds in the amphiphilic, thermoresponsive oligo(ethylene glycol) methacrylate-co-pentafluorostyrene (PFG30) copolymer that forms nanoparticle aggregates upon heating past temperatures of 30°C. The hydrophobic tracer, coumarin 6, was used to evaluate uptake of a hydrophobic molecule into PFG30 aggregates. Mass spectrometry analysis showed considerably greater delivery of encapsulated DHQZ analogs into infected cells and more rapid shrinkage of L. amazonensis communal vacuoles. Moreover, encapsulation in PFG30 augmented the efficacy of Retro-2 and its SAR analogs to clear both L. amazonensis and L. donovani infections. These studies demonstrate that encapsulation of compounds in PFG30 is a viable approach to dramatically increase bioavailability and efficacy of anti-Leishmania compounds.

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Nanoparticles: New agents toward treatment of leishmaniasis

Cited by 74 publications

References 81 publications

Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications

Biosynthesis of spinel nickel ferrite nanowhiskers and their biomedical applications

Nanobiotechnology for the Detection and Control of Waterborne Parasites

Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections

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