Nanoparticles Made From Xyloglucan-Block-Polycaprolactone Copolymers: Safety Assessment for Drug Delivery

Mazzarino, Letícia; Loch-Neckel, Gecioni; Bubniak, Lorena dos Santos; Ourique, Fabiana; Otsuka, Issei; Halila, Sami; Pedrosa, Rozangela Curi; Santos-Silva, Maria Cláudia; Lemos‐Senna, Elenara; Muniz, Edvani C.; Borsali, Rédouane

doi:10.1093/toxsci/kfv114

Cited by 72 publications

(46 citation statements)

References 43 publications

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“…Corresponding quantitative analyses by UV–vis spectrophotometer revealed that the hemolysis rates of the NBOF‐P‐FA were all lower than 3% (Figure 4B), far lower than the critical safe hemolytic ratio set by ISO/TR7406. [ 22 ] These results identified its excellent hemocompatibility, making it possible for in vivo administration.…”

Section: Resultsmentioning

confidence: 97%

Bismuth‐Based Mesoporous Nanoball Carrying Sorafenib for Computed Tomography Imaging and Synergetic Chemoradiotherapy of Hepatocellular Carcinoma

Zhang

Liu

et al. 2020

Adv Healthcare Materials

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Sorafenib (SOR), a multi-kinase inhibitor for advanced hepatocellular carcinoma (HCC), reveals a limited therapeutic effect due to a lack of selectivity and evident drug resistance. In the present study, bismuth-based mesoporous nanomaterial (NBOF) is loaded with SOR and then coated with polyethylene glycol and folic acid conjugates (P-FA) to form an NBOF@SOR-P-FA nanocarrier system. The system achieves significantly enhanced anti-cancer efficacy by combining chemotherapy with radiotherapy. To evaluate the effect of synergistic treatment, cytotoxicity detection, Live/Dead staining, apoptotic assay, and Western blot analysis are performed.

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Section: Resultsmentioning

confidence: 97%

Bismuth‐Based Mesoporous Nanoball Carrying Sorafenib for Computed Tomography Imaging and Synergetic Chemoradiotherapy of Hepatocellular Carcinoma

Zhang

Liu

et al. 2020

Adv Healthcare Materials

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“…They evaluated the toxicity through in vitro and in in vivo assays. The results did not indicate toxicity effects, being the material able to act as nanocarriers for drug delivery [24].…”

Section: Introductionmentioning

confidence: 78%

Drug carrier systems made from self-assembled glyco-nanoparticles of maltoheptaose-b-polyisoprene enhanced the distribution and activity of curcumin against cancer cells

Caldas

Lazarin-Bidóia²,

Nakamura³

et al. 2020

Journal of Molecular Liquids

Self Cite

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Controlled self-assembly of polymeric systems behave according to their composition and physicalchemical properties. Inclusion of a guest molecule may influence interactions and response to the media and to other surfaces and bodies, for example, cells. Hence, loading the polymeric system with curcumin (CUR), a natural and anticancer drug, confer interesting features to the carrier material.Micelle formation was achieved, in aqueous solution of carbohydrate-based block copolymer consisting in maltoheptaose-block-polyisoprene (MH-b-PI 3.8kDa ), by adding a large amount of water (a selective solvent for maltoheptaose, MH) into a solution of well-dissolved MH-b-PI 3.8kDa (THF/H 2 O 9:1 (% w/w)]. Morphology and size (ca. 89 nm) of these glyco-nanoparticles were characterized using light scattering (static and dynamic modes -SLS and DLS) complemented by nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM) and atomic force microscopy (AFM). The lyophilization efficiency was confirmed by measuring the relation between final and initial diameters (S f /S i ). CUR was successfully loaded into the nanoparticles with an entrapment efficiency of ca. 70%. CUR-charged nanoparticles showed stability into simulated gastric and intestinal fluids. Such micelles served as drug delivery system to carry CUR and presented a great role in wiping out unhealthy cells from many sorts.

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“…9 , Figure S6 ). In short, the antibacterial peptides RGD-hylin a1 enriched to HMS-COOH were released after RGD-hylin a1-HMS targeted the tumor and achieved a synergistic effect of tumor inhibition with no side effects in vivo 38 , 39 .…”

Section: Discussionmentioning

confidence: 99%

A pH-dependent Antibacterial Peptide Release Nano-system Blocks Tumor Growth in vivo without Toxicity

Cao

Zhang

Shan

et al. 2017

Sci Rep

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In this study, we designed a nano-system where a novel antibacterial peptide RGD-hylin a1 with reduced hemolysis than the commonly studied melittin was loaded onto mesoporous silica (HMS). We found out that the designed nano-system, RGD-hylin a1-HMS, released RGD-hylin a1 in a pH-dependent manner. It caused apoptosis of cancer cells at low dosage of the antibacterial peptide at pH = 5.5, but was safe to the cells at pH = 7. The hemolytic activity of RGD-hylin a1 itself was reduced by 50~100% by the nano-system depending on the dosage. When this nano-system was administered to tumor-bearing mice at low dosage via intravenous injection, the growth of the solid tumor was blocked by the RGD-hylin a1-HMS nano-system with a 50–60% inhibition rate relative to the PBS-treated control group in terms of tumor volume and weight. Further, the hemolytic activity of RGD-hylin a1 was completely eliminated within the delivery system with no other side effects observed. This study demonstrates that this smart pH-dependent antibacterial peptide release nano-system has superior potential for solid tumor treatments through intravenous administration. This smart-releasing system has great potential in further clinical applications.

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Nanoparticles Made From Xyloglucan-Block-Polycaprolactone Copolymers: Safety Assessment for Drug Delivery

Cited by 72 publications

References 43 publications

Bismuth‐Based Mesoporous Nanoball Carrying Sorafenib for Computed Tomography Imaging and Synergetic Chemoradiotherapy of Hepatocellular Carcinoma

Bismuth‐Based Mesoporous Nanoball Carrying Sorafenib for Computed Tomography Imaging and Synergetic Chemoradiotherapy of Hepatocellular Carcinoma

Drug carrier systems made from self-assembled glyco-nanoparticles of maltoheptaose-b-polyisoprene enhanced the distribution and activity of curcumin against cancer cells

A pH-dependent Antibacterial Peptide Release Nano-system Blocks Tumor Growth in vivo without Toxicity

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