Nanoparticles in the Treatment of Infections Caused by Multidrug-Resistant Organisms

Lee, Nan Yao; Ko, Wen Chien; Hsueh, Po-Ren

doi:10.3389/fphar.2019.01153

Cited by 410 publications

(265 citation statements)

References 77 publications

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“…In this section, the basic characteristics of each type of synthesis are briefly described. In chemical synthesis, the Turkevich method and Brust-Schiffrin synthesis are mainly used [43]. The Turkevich method is based on the reduction of the boiling solution of silver salt with a solution of citrate salt.…”

Section: Synthesis Of Agnpsmentioning

confidence: 99%

“…One problematic aspect of AgNPs wound dressings is that there are reported cases of bacterial resistance to AgNPs. For example, resistance to AgNPs attributed to sil genes has been reported in clinical isolates of Klebsiella pneumoniae and Enterobacter cloacae from burn cases [43]. Thus, the continuous development of a new combination of nanomaterials, antibiotics, polymers, methods of incorporation and types of reduction of silver to obtain various shapes of NPs is essentially necessary.…”

Section: Introductionmentioning

confidence: 99%

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Silver Nanomaterials for Wound Dressing Applications

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Silver nanoparticles (AgNPs) have recently become very attractive for the scientific community due to their broad spectrum of applications in the biomedical field. The main advantages of AgNPs include a simple method of synthesis, a simple way to change their morphology and high surface area to volume ratio. Much research has been carried out over the years to evaluate their possible effectivity against microbial organisms. The most important factors which influence the effectivity of AgNPs against microorganisms are the method of their preparation and the type of application. When incorporated into fabric wound dressings and other textiles, AgNPs have shown significant antibacterial activity against both Gram-positive and Gram-negative bacteria and inhibited biofilm formation. In this review, the different routes of synthesizing AgNPs with controlled size and geometry including chemical, green, irradiation and thermal synthesis, as well as the different types of application of AgNPs for wound dressings such as membrane immobilization, topical application, preparation of nanofibers and hydrogels, and the mechanism behind their antimicrobial activity, have been discussed elaborately.

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Section: Synthesis Of Agnpsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Silver Nanomaterials for Wound Dressing Applications

et al. 2020

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“…Nevertheless, there are some limitations to the use of these nanomaterials before their successful translation to clinics. One is the limited amount of data on the use of such systems to tackle infection in in vivo models, thus preventing adequate assessment of optimal dose, appropriate administration routes and possible interaction of nanoparticles with cells and tissues, whose toxicological profile is not completely understood ( Baptista et al, 2018 ; Lee et al, 2019 ).…”

Section: Alternative Antibacterial Therapiesmentioning

confidence: 99%

Tackling Multidrug Resistance in Streptococci – From Novel Biotherapeutic Strategies to Nanomedicines

et al. 2020

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The pyogenic streptococci group includes pathogenic species for humans and other animals and has been associated with enduring morbidity and high mortality. The main reason for the treatment failure of streptococcal infections is the increased resistance to antibiotics. In recent years, infectious diseases caused by pyogenic streptococci resistant to multiple antibiotics have been raising with a significant impact to public health and veterinary industry. The rise of antibiotic-resistant streptococci has been associated to diverse mechanisms, such as efflux pumps and modifications of the antimicrobial target. Among streptococci, antibiotic resistance emerges from previously sensitive populations as result of horizontal gene transfer or chromosomal point mutations due to excessive use of antimicrobials. Streptococci strains are also recognized as biofilm producers. The increased resistance of biofilms to antibiotics among streptococci promote persistent infection, which comprise circa 80% of microbial infections in humans. Therefore, to overcome drug resistance, new strategies, including new antibacterial and antibiofilm agents, have been studied. Interestingly, the use of systems based on nanoparticles have been applied to tackle infection and reduce the emergence of drug resistance. Herein, we present a synopsis of mechanisms associated to drug resistance in (pyogenic) streptococci and discuss some innovative strategies as alternative to conventional antibiotics, such as bacteriocins, bacteriophage, and phage lysins, and metal nanoparticles. We shall provide focused discussion on the advantages and limitations of agents considering application, efficacy and safety in the context of impact to the host and evolution of bacterial resistance.

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“…For NPs combined with antibiotics, the antimicrobial effects were found to be increased considerably. [ 206 ] Gandhi and Khan reported enhanced antimicrobial activity of AgNPs in the presence of bacitracin against E. coli and S. paratyphi (control 0 mm, test 22 and 18 mm inhibition zone, respectively), ampicillin against Corynebacterium diphtheria (control 0 mm, test 14 mm), kanamycin against K. pneumoniae (control 19 mm, test 30 mm), for gentamycin against P. aeruginosa (control 18 mm, test 34 mm), and bacitracin, gentamycin, erythromycin, and ciprofloxacin against S. aureus (control 0, 14, 19, and 21 mm, test 12, 29, 32, and 30 mm, respectively). [ 38 ] Singh et al found an antimicrobial activity of biosynthesized AgNPs against B. anthracis , B. cereus , E. coli , C. albicans, V. parahaemolyticus , and S. enterica .…”

Section: Antimicrobial Efficacy Of Nanoparticlesmentioning

confidence: 99%

Metal Nanoparticle–Microbe Interactions: Synthesis and Antimicrobial Effects

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Rizvi

et al. 2020

Part & Part Syst Charact

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metal solution, reduction of the metal ions leads to the generation of metal atom clustering generating nanosized particles. A characteristic of biosynthetic NPs is their high stability as the organisms provide their own biomolecular capping agent(s). [1] While plant-based production of NPs is now considered a scientific curiosity rather than a promising biotechnology, [2] bacteriamediated NP biosynthesis offers better chances, in light of the poorly characterized microbial diversity and the complex chemistry of enzymes in metal-reducing bacteria. Two recent works focused on directed biofabrication of CdSe-nanoparticles through regulating extracellular electron transfer [3] and the biosynthesis of highly active copper NPs (CuNP) by Shewanella oneidensis. [4] However, the description of molecular mechanism(s) involved in the biosynthesis of NPs has received little attention, which is the focus of this review.The CFCF or culture supernatants (CS) of bacteria mediate the synthesis of AgNPs [5] as presented in this section. The CFCF from the family Enterobacteriaceae reduce silver ions to AgNPs ( Table 1). CFCF of Klebsiella pneumoniae, Escherichia coli, and Metal nanoparticles (NPs), chalcogenides, and carbon quantum dots can be easily synthesized from whole microorganisms (fungi and bacteria) and cell-free sterile filtered spent medium. The particle size distribution and the biosynthesis time can be somewhat controlled through the biomass/metal solution ratio. The biosynthetic mechanism can be explained through the ionreduction theory and UV photoconversion theory. Formation of biosynthetic NPs is part of the detoxification strategy employed by microorganisms, either in planktonic or biofilm form, to reduce the chemical toxicity of metal ions. In fact, most reports on NP biosynthesis show extracellular metal ion reduction. This is important for environmental and industrial applications, particularly in biofilms, as it allows in principle high biosynthetic rates. The antimicrobial and antifungal effect on biosynthetic NPs can be explained in terms of reactive oxygen species and can be enhanced by the capping agents attached to the NP during the biosynthesis process. Industrial applications of NP biosynthesis are still lagging, due to the difficulty of controlling NP size and low titer. Further, the environmental assessment of biosynthetic NPs has not yet been carried out. It is expected that further advancements in biosynthetic NP research will lead to applications, particularly in environmental biotechnology.

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Nanoparticles in the Treatment of Infections Caused by Multidrug-Resistant Organisms

Cited by 410 publications

References 77 publications

Silver Nanomaterials for Wound Dressing Applications

Silver Nanomaterials for Wound Dressing Applications

Tackling Multidrug Resistance in Streptococci – From Novel Biotherapeutic Strategies to Nanomedicines

Metal Nanoparticle–Microbe Interactions: Synthesis and Antimicrobial Effects

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