Nanoparticles in the fight against mosquito-borne diseases: bioactivity of Bruguiera cylindrica-synthesized nanoparticles against dengue virus DEN-2 (in vitro) and its mosquito vector Aedes aegypti (Diptera: Culicidae)

Murugan, Kadarkarai; Dinesh, Devakumar; Paulpandi, Manickam; Althbyani, Abdulaziz Dakhellah Meqbel; Subramaniam, Jayapal; Madhiyazhagan, Pari; Wang, Lan; Suresh, Udaiyan; Kumar, Palanisamy Mahesh; Mohan, Jagathish; Rajaganesh, Rajapandian; Wei, Hui; Kalimuthu, K.; Parajulee, Megha N.; Mehlhorn, Heinz; Benelli, Giovanni

doi:10.1007/s00436-015-4676-8

Cited by 65 publications

(37 citation statements)

References 65 publications

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“…In addition, recent research highlighted the potential of plant-synthesized nanoparticles as inhibitors of dengue growth (Sujitha et al 2015;Benelli 2016a). From a mechanistic point of view, green-synthesized silver nanoparticles act as inhibitors of the production of dengue DEN-2 viral envelope (E) protein in Vero cells, and downregulate the expression of dengue viral E gene (Murugan et al 2015a). However, a certain level of cytotoxicity of the tested nanoparticles has been reported (e.g.…”

Section: The Rise Of Dengue Zika Virus and Other Arbovirusesmentioning

confidence: 99%

Declining malaria, rising of dengue and Zika virus: insights for mosquito vector control

2016

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The fight against mosquito-borne diseases is a challenge of huge public health importance. To our mind, 2015 was an extraordinary year for malaria control, due to three hot news: the Nobel Prize to Youyou Tu for the discovery of artemisinin, the development of the first vaccine against Plasmodium falciparum malaria [i.e. RTS,S/AS01 (RTS,S)], and the fall of malaria infection rates worldwide, with special reference to sub-Saharan Africa. However, there are major challenges that still deserve attention, in order to boost malaria prevention and control. Indeed, parasite strains resistant to artemisinin have been detected, and RTS,S vaccine does not offer protection against Plasmodium vivax malaria, which predominates in many countries outside of Africa. Furthermore, the recent outbreaks of Zika virus infections, occurring in South America, Central America and the Caribbean, represent the most recent of four arrivals of important arboviruses in the Western Hemisphere, over the last 20 years. Zika virus follows dengue (which slyly arrived in the hemisphere over decades and became more aggressive in the 1990s), West Nile virus (emerged in 1999) and chikungunya (emerged in 2013). Notably, there are no specific treatments for these arboviruses. The emerging scenario highlights that the effective and ecofriendly control of mosquito vectors, with special reference to highly invasive species such as Aedes aegypti and Aedes albopictus, is crucial. The concrete potential of screening plant species as sources of metabolites for parasitological purposes is worthy of attention, as elucidated by the Y. Tu's example. Notably, plant-borne molecules are often effective at few parts per million against Aedes, Ochlerotatus, Anopheles and Culex young instars, can be used for the rapid synthesis of mosquitocidal nanoformulations and even employed to prepare cheap repellents with low human toxicity. In addition, behaviour-based control tools relying to the employ of sound traps and the manipulation of swarming behaviour (i.e. Blure and kill^approach) are discussed. The importance of further research on the chemical cues routing mosquito swarming and mating dynamics is highlighted. Besides radiation, transgenic and symbiont-based mosquito control approaches, an effective option may be the employ of biological control agents of mosquito young instars, in the presence of ultra-low quantities of nanoformulated botanicals, which boost their predation rates.

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Section: The Rise Of Dengue Zika Virus and Other Arbovirusesmentioning

confidence: 99%

Declining malaria, rising of dengue and Zika virus: insights for mosquito vector control

2016

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“…Rampant growth of human population has led to major challenges of sustainable food production and disease control in the twenty-first century (Roni et al, 2015). Arthropods are vectors of some deadly diseases, which can lead to epidemics or pandemics (Murugan et al, 2015). On top of the list are mosquitoes (Diptera: Culicidae) that are a cause of a major concern around the world because they can act as vectors of a variety of harmful pathogens and parasites (Benelli, 2016;Benelli and Mehlhorn, 2016).…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Nanotechnology for Detection and Control of Aedes aegypti-Borne Diseases

Campos

Oliveira

Abrantes

et al. 2020

Front. Bioeng. Biotechnol.

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Arboviruses such as yellow fever, dengue, chikungunya and zika are transmitted mainly by the mosquito vector Aedes aegypti. Especially in the tropics, inefficacy of mosquito control causes arboviruses outbreaks every year, affecting the general population with debilitating effects in infected individuals. Several strategies have been tried to control the proliferation of A. aegypti using physical, biological, and chemical control measures. Other methods are currently under research and development, amongst which the use of nanotechnology has attracted a lot of attention of the researchers in relation to the production of more effective repellents and larvicides with less toxicity, and development of rapid sensors for the detection of virus infections. In this review, the utilization of nano-based formulations on control and diagnosis of mosquito-borne diseases were discussed. We also emphasizes the need for future research for broad commercialization of nano-based formulations in world market aiming a positive impact on public health.

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“…This is particularly true for studies focused on mosquito vectors. However, recent research showed that in some cases ultra-low doses of green-synthesized nanocomposites may boost the predation efficiency of natural enemies (e.g., copepods, tadpoles, and mosquito fishes) against mosquito young instars (e.g., Murugan et al 2015aMurugan et al ,b,c, 2016aSubramaniam et al 2015Subramaniam et al , 2016. As regards to genotoxicity, Murugan et al (2016c) recently reported no significant damages of Carassius auratus erythrocytes post-treatment with graphene quantum dots at doses lower than 25 ppm.…”

Section: Discussionmentioning

confidence: 99%

Artemisia absinthium-borne compounds as novel larvicides: effectiveness against six mosquito vectors and acute toxicity on non-target aquatic organisms

Govindarajan

Benelli

2016

Parasitol Res

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The eco-friendly control of mosquito vectors is a crucial challenge of public health importance. Here we evaluated the larvicidal potential of Artemisia absinthium essential oil (EO) and its three major chemical constituents against six mosquito vectors: Anopheles stephensi, Anopheles subpictus, Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Culex tritaeniorhynchus. The EO was obtained by leaf hydrodistillation. Its chemical composition was analyzed using gas chromatography-mass spectrometry. Major components were (E)-β-farnesene (31.6 %), (Z)-en-yn-dicycloether (11.12 %), and (Z)-β-ocimene (27.8 %). The EO was toxic effect against larval populations of An. stephensi, An. subpictus, Ae. aegypti, A e . a l b o p i c t u s, C x . q u i n q u e f a s c i a t u s , and C x . tritaeniorhynchus, with LC 50 values of 41. 85, 52.02, 46.33, 57.57, 50.57, and 62.16 μg/ml. (E)-β-farnesene, (Z)-en-yndicycloether, and (Z)-β-ocimene were highly effective on An. stephensi (LC 50 = 8.13, 16.24 and 25.84 μg/ml) followed by An. subpictus (LC 50 = 10.18, 20.99, and 30.86 μg/ml), Ae. aegypti (LC 50 = 8.83,17.66, and 28.35 μg/ml), Ae. albopictus (LC 50 = 11.38,23.47, and 33.72 μg/ml), Cx. quinquefasciatus (LC 5 0 = 9.66, 19.76, and 31.52 μ g/ml), and Cx. tritaeniorhynchus (LC 50 = 12.51,25.88, and 37.13 μg/ml). Notably, the EO and its major compounds were safer to the non-target organisms Chironomous circumdatus, Anisops bouvieri and Gambusia affinis, with LC 50 values ranging from 207.22 to 4385 μg/ml. Overall, our results highlight that (E)-β-farnesene, (Z)-en-yn-dicycloether, and (Z)-β-ocimene from the A. absinthium EO represent promising eco-friendly larvicides against six key mosquito vectors with moderate toxicity against non-target organisms.

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Nanoparticles in the fight against mosquito-borne diseases: bioactivity of Bruguiera cylindrica-synthesized nanoparticles against dengue virus DEN-2 (in vitro) and its mosquito vector Aedes aegypti (Diptera: Culicidae)

Cited by 65 publications

References 65 publications

Declining malaria, rising of dengue and Zika virus: insights for mosquito vector control

Declining malaria, rising of dengue and Zika virus: insights for mosquito vector control

Recent Developments in Nanotechnology for Detection and Control of Aedes aegypti-Borne Diseases

Artemisia absinthium-borne compounds as novel larvicides: effectiveness against six mosquito vectors and acute toxicity on non-target aquatic organisms

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