Nanoparticles from the Cosmetics and Medical Industries in Legal and Environmental Aspects

Włodarczyk, Renata; Kwarciak‐Kozłowska, Anna

doi:10.3390/su13115805

Cited by 20 publications

(12 citation statements)

References 62 publications

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“…in identifying and investigating the safety aspects of nanomaterials in cosmetics. There are compilations in the literature that summarize the legal aspects of nanomaterials [ 138 ] or the use of nanomaterials specifically in cosmetics [ 139 ]. Here, we briefly summarize the main recommendations of a few important guidance documents.…”

Section: Regulatory Guidelines Of Cosmetics and Cosmeceuticalsmentioning

confidence: 99%

Nanotechnology in Cosmetics and Cosmeceuticals—A Review of Latest Advancements

Gupta

Mohapatra

Mishra

et al. 2022

Gels

106

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Nanotechnology has the potential to generate advancements and innovations in formulations and delivery systems. This fast-developing technology has been widely exploited for diagnostic and therapeutic purposes. Today, cosmetic formulations incorporating nanotechnology are a relatively new yet very promising and highly researched area. The application of nanotechnology in cosmetics has been shown to overcome the drawbacks associated with traditional cosmetics and also to add more useful features to a formulation. Nanocosmetics and nanocosmeceuticals have been extensively explored for skin, hair, nails, lips, and teeth, and the inclusion of nanomaterials has been found to improve product efficacy and consumer satisfaction. This is leading to the replacement of many traditional cosmeceuticals with nanocosmeceuticals. However, nanotoxicological studies on nanocosmeceuticals have raised concerns in terms of health hazards due to their potential skin penetration, resulting in toxic effects. This review summarizes various nanotechnology-based approaches being utilized in the delivery of cosmetics as well as cosmeceutical products, along with relevant patents. It outlines their benefits, as well as potential health and environmental risks. Further, it highlights the regulatory status of cosmeceuticals and analyzes the different regulatory guidelines in India, Europe, and the USA and discusses the different guidelines and recommendations issued by various regulatory authorities. Finally, this article seeks to provide an overview of nanocosmetics and nanocosmeceuticals and their applications in cosmetic industries, which may help consumers and regulators to gain awareness about the benefits as well as the toxicity related to the continuous and long-term uses of these products, thus encouraging their judicious use.

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Section: Regulatory Guidelines Of Cosmetics and Cosmeceuticalsmentioning

confidence: 99%

Nanotechnology in Cosmetics and Cosmeceuticals—A Review of Latest Advancements

Gupta

Mohapatra

Mishra

et al. 2022

Gels

106

View full text Add to dashboard Cite

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“…The degree of toxicity of a particular NM depends on the extent of exposure and its physicochemical properties, as well as the sensitivity of the test organism. To compare the toxicity of different types of NMs, a group of scientists from Netherlands evaluated the toxicities of multiple types of NMs and classified the hazard of different NMs into four classes based on their respective nanoreference values, including class 1 high toxicity with a nano reference value of 0.01 fibers cm À3 for rigid carbon nanofibers and metal oxide fibers (e.g., SWCNT), class 2 medium or low toxicity with a nano reference value of 20,000 particles cm À3 for granular NM (nonfibrous), stable in the environment, with a density >6 g cm À3 (e.g., Ag and CeO 2 NPs), and class 3 medium or low toxicity with a nano reference value of 40,000 particles cm À3 for granular NM and nanofibers, stable in the environment with a density <6 g cm À3 (e.g., TiO 2 and ZnO NPs), and class 4 low toxicity for granular NMs, unstable or soluble in water (e.g., NaCl and lipid NPs) (Van Broekhuizen et al, 2012;Włodarczyk & Kwarciak-Kozłowska, 2021).…”

Section: Hazard Identificationmentioning

confidence: 99%

Toxicokinetics, dose–response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives

Chen

Riviere

Lin

2022

WIREs Nanomed Nanobiotechnol

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The rapid growth of nanomaterial applications has raised safety concerns for human health. A number of studies have been conducted to assess the toxicokinetics, toxicology, dose–response, and risk assessment of different nanomaterials using in vitro and in vivo animal and human models. However, current studies cannot meet the demand for efficient assessment of toxicokinetics, dose–response relationships, or the toxicological risk arising from the rapidly increasing number of newly synthesized nanomaterials. In this article, we review the methods for conducting toxicokinetics, hazard identification, dose–response, exposure, and risk assessment studies of nanomaterials, identify the knowledge gaps, and discuss the challenges remaining. We provide the rationale behind the appropriate design of nanomaterial plasma toxicokinetic and tissue distribution studies, including caveats on the interpretation and correlation of in vitro and in vivo toxicology studies. The potential of using physiologically based pharmacokinetic (PBPK) models to extrapolate toxicokinetic and toxicity findings from in vitro to in vivo and from animals to humans is discussed, and the knowledge gaps of PBPK modeling for nanomaterials are identified. While challenges still exist, there has been progress in the toxicokinetics, hazard identification, and risk assessment of nanomaterials in the past two decades. Recent advancements in the field are highlighted with relevant examples. We also share latest guidelines as well as our perspectives on future studies needed to characterize the toxicokinetics, toxicity, and dose–response relationship in support of nanomaterial risk assessment.This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials Toxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine

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“…The FDA explicitly allows the use of silver nanoparticles in the biomedical field where they are shown to be safe and biocompatible, and where they meet appropriate quality standards in the manufacturing process. Recently, several silver nanoparticle products have been used in fabrics, cosmetics, storage containers, and medicine [11], reflecting the biocompatibility of silver nanoparticles for application to the skin.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Coated by Water Soluble Chitosan and Its Potency as Non-Alcoholic Hand Sanitizer Formulation

et al. 2022

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The synthesis of silver nanoparticles using plant extracts, widely known as a green synthesis method, has been extensively studied. Nanoparticles produced through this method have applications as antibacterial agents. Bacterial and viral infection can be prevented by use of antibacterial agents such as soap, disinfectants, and hand sanitizer. Silver nanoparticles represent promising hand sanitizer ingredients due to their antibacterial activity and can enable reduced use of alcohol and triclosan. This study employed silver nanoparticles synthesized using Kepok banana peel extract (Musa paradisiaca L.). Nanoparticle effectiveness as a hand sanitizer can be enhanced by coating with a biocompatible polymer such as chitosan. The characterization of silver nanoparticles was conducted using UV-Vis, with an obtained peak at 434.5 nm. SEM-EDX analysis indicated nanoparticles with a spherical morphology. Silver nanoparticles coated with chitosan were characterized through FTIR to verify the attached functional groups. Gel hand sanitizers were produced using silver nanoparticles coated with different chitosan concentrations. Several tests were undertaken to determine the gel characteristics, including pH, syneresis, and antibacterial activity. Syneresis leads to unstable gels, but was found to be inhibited by adding chitosan at a concentration of 2%. Antibacterial activity was found to increase with increase in chitosan concentration.

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Nanoparticles from the Cosmetics and Medical Industries in Legal and Environmental Aspects

Cited by 20 publications

References 62 publications

Nanotechnology in Cosmetics and Cosmeceuticals—A Review of Latest Advancements

Nanotechnology in Cosmetics and Cosmeceuticals—A Review of Latest Advancements

Toxicokinetics, dose–response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives

Green Synthesis of Silver Nanoparticles Coated by Water Soluble Chitosan and Its Potency as Non-Alcoholic Hand Sanitizer Formulation

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