Nanoparticles for drug delivery to the anterior segment of the eye

Janagam, Dileep R.; Wu, Liangliang; Lowe, Timothy J.

doi:10.1016/j.addr.2017.04.001

Cited by 252 publications

(152 citation statements)

References 240 publications

(402 reference statements)

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“…One example of an ion-responsive material is gellan gum, an anionic polysaccharide produced by the bacterium Pseudomonas elodea [73]. After dispersion in aqueous solutions, gellan gum undergoes a liquid-gel transition in response to increases in ionic strength [74]. This sol-gel transition process is induced by the presence of monovalent or divalent ions, such as Na + and Ca 2+ .…”

Section: In-situ-forming Gels Influenced By Ionic Strengthmentioning

confidence: 99%

Polysaccharides in Ocular Drug Delivery

et al. 2019

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Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

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Section: In-situ-forming Gels Influenced By Ionic Strengthmentioning

confidence: 99%

Polysaccharides in Ocular Drug Delivery

et al. 2019

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“…A growing area of ocular research concerns the delivery of drugs and gene therapies [128][129][130][131]. Many papers have described the use of nanoparticles as drug delivery systems, which offer attractive advantages over conventional methods including targeted delivery, increased drug bioavailability with lower doses, sustained release, and reduced side effects [132].…”

Section: Future Perspectives: Potential Applications Of Tnts In Oculamentioning

confidence: 99%

Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease

Chinnery

Keller

2020

BioMed Research International

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Cellular communication is an essential process for the development and maintenance of all tissues including the eye. Recently, a new method of cellular communication has been described, which relies on formation of tubules, called tunneling nanotubes (TNTs). These structures connect the cytoplasm of adjacent cells and allow the direct transport of cellular cargo between cells without the need for secretion into the extracellular milieu. TNTs may be an important mechanism for signaling between cells that reside long distances from each other or for cells in aqueous environments, where diffusion-based signaling is challenging. Given the wide range of cargoes transported, such as lysosomes, endosomes, mitochondria, viruses, and miRNAs, TNTs may play a role in normal homeostatic processes in the eye as well as function in ocular disease. This review will describe TNT cellular communication in ocular cell cultures and the mammalian eye in vivo, the role of TNTs in mitochondrial transport with an emphasis on mitochondrial eye diseases, and molecules involved in TNT biogenesis and their function in eyes, and finally, we will describe TNT formation in inflammation, cancer, and stem cells, focusing on pathological processes of particular interest to vision scientists.

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“…9 Various methods, such as punctum plugs, drugeluting contact lenses, ocular implants, and nanocarrier systems, have been explored to prolong the pre-corneal time and improve the drug concentration in the ocular tissues for treating anterior ocular segment diseases. [10][11][12] However, limiting factors of these methods are biodegradation, an inability to precisely control drug delivery, and idiopathic harm to the eyeball. 7,[13][14][15] The continuous topical ocular instillation drug delivery (CTOIDD) system in our study consists of a cribriform polyvinyl chloride tube with a ring shape and an attached drug pump ( Figure 1A).…”

Section: Introductionmentioning

confidence: 99%

<p>Comparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop</p>

Lin

Zhao

Huang

et al. 2020

DDDT

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Background: The aim of this study was to compare the distribution characteristics and ocular pharmacokinetics of norvancomycin (NVCM) in ocular tissues of the anterior segment between continuous topical ocular instillation and hourly administration of eye drop in rabbits. Methods: Sixty rabbits were randomly divided into two groups: continuous topical ocular instillation drug delivery (CTOIDD) group and eye drop (control) group. In the CTOIDD group, NVCM solution (50 mg/mL) was perfused to the ocular surface using the CTOIDD system at 2 mL/ h up to 10 h and the same solution was administered at one drop (50 μL) per hour for 10 h in the control group. Animals (N=6 per time-point per group) were humanely killed at 2, 4, 6, 10, and 24 h to analyze their ocular tissues and plasma. The concentrations of NVCM in the conjunctiva, cornea, aqueous humour, iris, ciliary body and plasma were measured by HPLC with photodiode array detector. The pharmacokinetic parameters were calculated by Kinetica 5.1. Results: The highest concentrations of NVCM for the CTOIDD group and control group were 2105.45±919.89 μg/g and 97.18±43.14 μg/g in cornea, 3033.92±1061.95 μg/g and 806.99 ±563.02 μg/g in conjunctiva, 1570.19±402.87 μg/g and 46.93±23.46 μg/g in iris, 181.94 ±47.11 μg/g and 15.38±4.00 μg/g in ciliary body, 29.78±4.90 μg/mL and 3.20±1.48 μg/mL in aqueous humour, and 26.89±5.57 μg/mL and 1.90±1.87 μg/mL in plasma, respectively. The mean NVCM levels significantly increased at all time-points in cornea, iris, and ciliary body (p<0.05) in the CTOIDD group. The AUC 0-24 values in the CTOIDD group were 27,543.70 μg•h/g in cornea, 32,514.48 μg•h/g in conjunctiva, 8631.05 μg•h/g in iris, 2194.36 μg•h/g in ciliary body and 343.9 μg•h/mL in aqueous humour, which were higher than for the eye drop group in all tissues. Conclusion: Since continuous instillation of NVCM with CTOIDD could reach significantly higher concentrations and was sustained for a longer period compared with hourly administration of eye drop, CTOIDD administered NVCM could be a possible method to treat bacterial keratitis.

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Nanoparticles for drug delivery to the anterior segment of the eye

Cited by 252 publications

References 240 publications

Polysaccharides in Ocular Drug Delivery

Polysaccharides in Ocular Drug Delivery

Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease

<p>Comparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop</p>

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