Nanoparticles for cancer therapy: a review of influencing factors and evaluation methods for biosafety

Li, Jinghua; Wu, Tao; Li, Shiman; Chen, Xinyan; Deng, Zhiming; Zhong, Liping

doi:10.1007/s12094-023-03117-5

Cited by 10 publications

(6 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The physicochemical characteristics of nanoparticles, including particle size, morphological and structural variations, surface charge, surface chemical modifications, chemical properties, composition, aggregation state, and stability, play crucial roles in influencing their biosafety. Additionally, factors such as concentration, crystallization, route of administration, dose, tissue distribution range of nanoparticles, cell type, and animal species are all contributors to their biosafety [ 68 ]. These variables impact cellular uptake, intracellular transport and localization, interaction with biomolecules like proteins and DNA, as well as in vivo distribution and metabolic clearance, thereby causing specific biological effects.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Nanomedicine on Soft Tissue Sarcoma Treated by Radiotherapy and/or Hyperthermia: A Review

Zachou,

Kouloulias,

Chalkia

et al. 2024

Cancers

View full text Add to dashboard Cite

This article presents a comprehensive review of nanoparticle-assisted treatment approaches for soft tissue sarcoma (STS). STS, a heterogeneous group of mesenchymal-origin tumors with aggressive behavior and low overall survival rates, necessitates the exploration of innovative therapeutic interventions. In contrast to conventional treatments like surgery, radiotherapy (RT), hyperthermia (HT), and chemotherapy, nanomedicine offers promising advancements in STS management. This review focuses on recent research in nanoparticle applications, including their role in enhancing RT and HT efficacy through improved drug delivery systems, novel radiosensitizers, and imaging agents. Reviewing the current state of nanoparticle-assisted therapies, this paper sheds light on their potential to revolutionize soft tissue sarcoma treatment and improve patient therapy outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

The Impact of Nanomedicine on Soft Tissue Sarcoma Treated by Radiotherapy and/or Hyperthermia: A Review

Zachou,

Kouloulias,

Chalkia

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…The biosafety of nanoparticles in vivo is largely influenced by their physicochemical properties, including particle shape, size, surface modification, surface charge, chemical properties, components, stability, and so on. [ 188 ] These factors will affect cellular uptake, interaction with biological macromolecules, biodistribution, biodegradation, and metabolic clearance, resulting in specific biological effects. After injection into the body, the stimulation caused by nanoparticles or their degradation products may induce a certain degree of inflammatory response, resulting in cellular and tissue damage.…”

Section: Challenges In Clinical Transformationmentioning

confidence: 99%

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

Cheng,

Shi,

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even under oxygen‐sufficient conditions. This metabolic alteration not only favors tumor cell progression and metastasis but also increases lactate accumulation in solid tumors. In addition to serving as a byproduct of glycolytic tumor cells, lactate also plays a central role in the construction of acidic and immunosuppressive tumor microenvironment, resulting in therapeutic tolerance. Recently, targeted drug delivery and inherent therapeutic properties of nanomaterials have attracted great attention, and research on modulating lactate metabolism based on nanomaterials to enhance antitumor therapy has exploded. In this review, the advanced tumor therapy strategies based on nanomaterials that interfere with lactate metabolism are discussed, including inhibiting lactate anabolism, promoting lactate catabolism, and disrupting the “lactate shuttle”. Furthermore, recent advances in combining lactate metabolism modulation with other therapies, including chemotherapy, immunotherapy, photothermal therapy, and reactive oxygen species‐related therapies, etc., which have achieved cooperatively enhanced therapeutic outcomes, are summarized. Finally, foreseeable challenges and prospective developments are also reviewed for the future development of this field.

show abstract

“…These unique capabilities enable enhanced drug delivery, improved therapeutic response, and reduced off-target effects. Moreover, the size of nanoparticles can also modulate their interactions with biological components, such as proteins, cell membranes, and intracellular organelles (15). The surface chemistry and charge of nanoparticles, which are intricately linked to their size, in uence their ability to escape immune recognition, traverse biological barriers, and engage speci c cellular receptors (16).…”

Section: Introductionmentioning

confidence: 99%

Size-Dependent Effects of Silver Nanoparticles in Colorectal Cancer Treatment: Apoptosis Activation, Anti-Metastatic Properties, and Tissue Accumulation

Karakurt,

BILGISEVEN,

CINAR

et al. 2024

Preprint

View full text Add to dashboard Cite

Nanoparticles possess unique characteristics due to their small size and high surface area-to-volume ratios, enabling facile interactions with biomolecules, cells, and tissues upon entry into the body. This study investigates the size-related effects of silver nanoparticles (AgNPs) in the context of colorectal cancer treatment. The proposed mechanism, resembling “Trojan horses”, elucidates the toxicity of AgNPs; AgNPs transport metallic silver across cell membranes and then dissolve intracellularly to release Ag2+ ions. To explore the impact of AgNP size, a range of AgNPs with varying sizes was synthesized. The cytotoxic effects of synthesized AgNPs (5 nm, 10 nm, 40 nm, and 100 nm) in colorectal cancer cell lines; CaCo-2, SW-620, DLD-1, HT-29, and healthy colon epithelial cell line CCD-18Co were determined in vitro. The distribution and amount of different-sized AgNPs in rat tissues at 24-hour and 48-hour post-administration were determined by ICP-MS method. Experimental findings revealed that the apoptotic pathway in DLD-1 and HT-29 cells was activated by AgNPs, and this activation exhibited a positive correlation with increasing AgNP size. Furthermore, an increase in size was associated with decreased metastatic properties, resulting in a reduced ability to form colonies. AgNP therapy induced the activation of proteins and genes involved in various pathways, including TGFβ, WNT, MAPK, PI3K-Akt, and p53. In vivo studies demonstrated the effective penetration of AgNPs into the circulatory system following intraperitoneal (IP) administration. These nanoparticles were found to accumulate extensively in the lungs, liver, heart, kidneys, and colon. 5 nm AgNPs were rapidly cleared from the kidney at 48 h, while 40 nm AgNPs exhibited the highest concentration in the lung at 24 h. Notably, different-sized AgNP nanoparticles exhibited distinct accumulation sites, suggesting a potential passive targeting approach for specific tissues. In conclusion, this study highlights the size-dependent effects of AgNPs in colorectal cancer treatment. The findings underscore the ability of AgNPs to activate apoptosis and modulate metastatic properties in colorectal cancer cells, with larger AgNPs exhibiting more pronounced effects. Moreover, the differential accumulation of AgNPs in various tissues offers a promising alternative strategy for passive targeting based on nanoparticle size. These insights contribute to the development of targeted therapies utilizing AgNPs in the field of cancer treatment.

show abstract

Nanoparticles for cancer therapy: a review of influencing factors and evaluation methods for biosafety

Cited by 10 publications

References 141 publications

The Impact of Nanomedicine on Soft Tissue Sarcoma Treated by Radiotherapy and/or Hyperthermia: A Review

The Impact of Nanomedicine on Soft Tissue Sarcoma Treated by Radiotherapy and/or Hyperthermia: A Review

Current Advances on Nanomaterials Interfering with Lactate Metabolism for Tumor Therapy

Size-Dependent Effects of Silver Nanoparticles in Colorectal Cancer Treatment: Apoptosis Activation, Anti-Metastatic Properties, and Tissue Accumulation

Contact Info

Product

Resources

About