Nanoparticles for Biosensors

Kang, Huizhi; Wang, Lin; O’Donoghue, Meghan B.; Cao, Y. Charles; Tan, Weihong

doi:10.1016/b978-044453125-4.50017-6

Cited by 9 publications

(3 citation statements)

References 128 publications

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“…Mesoporous materials have been synthesized using two key approaches: one is the soft-templating method and the other is the hard-templating method with desired morphology . It is mostly synthesized by using the soft-templating method because of the easy approach with a low molecular weight polymer like polyethylene glycol (PEG) as a surfactant. , Many researchers have employed iron oxide nanoparticles thoroughly because of their unique properties such as low Curie temperature, high magnetic susceptibility, high surface area-to-volume ratio, high surface energy, tunable pore size, and uniform distribution, which provide a high demand for in vivo and in vitro application in the field of biomedical science to targeted drug delivery, magnetic resonance imaging (MRI), cancer hyperthermia, catalysis, biosensing, environmental remediations, and other industrial applications . The use of iron nanoparticles in the biomedical field has led to significant advantages in terms of diagnosis, − biomedical detection, , therapy, and drug delivery. , The surface morphology and particle size of iron/iron oxide NPs could easily be controlled by a suitable synthetic method, which provides a specific application .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

et al. 2022

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In the present work, iron nanoparticles were synthesized in the α-Fe 2 O 3 phase with the reduction of potassium hexachloroferrate(III) by using l -ascorbic acid as a reducing agent in the presence of an amphiphilic non-ionic polyethylene glycol surfactant in an aqueous solution. The synthesized α-Fe 2 O 3 NPs were characterized by powder X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, atomic force microscopy, dynamic light scattering, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and ultraviolet–visible spectrophotometry. The powder X-ray diffraction analysis result confirmed the formation of α-Fe 2 O 3 NPs, and the average crystallite size was found to be 45 nm. The other morphological studies suggested that α-Fe 2 O 3 NPs were predominantly spherical in shape with a diameter ranges from 40 to 60 nm. The dynamic light scattering analysis revealed the zeta potential of α-Fe 2 O 3 NPs as −28 ± 18 mV at maximum stability. The ultraviolet–visible spectrophotometry analysis shows an absorption peak at 394 nm, which is attributed to their surface plasmon vibration. The cytotoxicity test of synthesized α-Fe 2 O 3 NPs was investigated against human carcinoma A549 lung cancer cells, and the biological adaptability exhibited by α-Fe 2 O 3 NPs has opened a pathway to biomedical applications in the drug delivery system. Our investigation confirmed that l -ascorbic acid-coated α-Fe 2 O 3 NPs with calculated IC 50 ≤ 30 μg/mL are the best suited as an anticancer agent, showing the promising application in the treatment of carcinoma A549 lung cancer cells.

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Section: Introductionmentioning

confidence: 99%

Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

et al. 2022

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“…NMs play an important role in enzyme-based biosensors, boosting a sensor’s efficiency and sensitivity. These novel nanoscale materials have unique features that can considerably increase the sensing capacities of biosensors [ 68 ]. By adding NMs into enzyme-based biosensors, the surface area-to-volume ratio may be greatly boosted, allowing for the immobilization of a greater number of enzyme molecules and improving the overall enzyme–substrate interaction [ 69 ].…”

Section: Nanomaterials That Are Generally Used In the Design Of Enzym...mentioning

confidence: 99%

Novel Approaches to Enzyme-Based Electrochemical Nanobiosensors

Kilic,

Singh,

Keles

et al. 2023

Biosensors

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Electrochemistry is a genuinely interdisciplinary science that may be used in various physical, chemical, and biological domains. Moreover, using biosensors to quantify biological or biochemical processes is critical in medical, biological, and biotechnological applications. Nowadays, there are several electrochemical biosensors for various healthcare applications, such as for the determination of glucose, lactate, catecholamines, nucleic acid, uric acid, and so on. Enzyme-based analytical techniques rely on detecting the co-substrate or, more precisely, the products of a catalyzed reaction. The glucose oxidase enzyme is generally used in enzyme-based biosensors to measure glucose in tears, blood, etc. Moreover, among all nanomaterials, carbon-based nanomaterials have generally been utilized thanks to the unique properties of carbon. The sensitivity can be up to pM levels using enzyme-based nanobiosensor, and these sensors are very selective, as all enzymes are specific for their substrates. Furthermore, enzyme-based biosensors frequently have fast reaction times, allowing for real-time monitoring and analyses. These biosensors, however, have several drawbacks. Changes in temperature, pH, and other environmental factors can influence the stability and activity of the enzymes, affecting the reliability and repeatability of the readings. Additionally, the cost of the enzymes and their immobilization onto appropriate transducer surfaces might be prohibitively expensive, impeding the large-scale commercialization and widespread use of biosensors. This review discusses the design, detection, and immobilization techniques for enzyme-based electrochemical nanobiosensors, and recent applications in enzyme-based electrochemical studies are evaluated and tabulated.

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“…Kang, H et al have effectively explained the application of nanoparticles in biosensors to increase its working efficiency. 53 Amperometric biosensors have been modified and tested with palladium and platinum nanoparticles by L. Shkotova et. al.…”

Section: (I) Detection Of Ethanol Concentration In Alcoholic Beveragesmentioning

confidence: 99%

Amperometric Biosensors as an Analytical Tool in Food, Dairy and Fermentation Industries

Sivashankar¹,

Kumar²,

Kiran³

et al. 2020

IJPSRR

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Biosensors are analytical devices that sense the presence of a biological component in the vicinity and generate signals that can be easily detected using a physicochemical detector. With the advent of biosensors, conventional methodologies such as the detection of contaminants in pharmaceutical industries and the diagnosis of diseases via biomarkers have been accelerated to a great extent. The review highlights the use of Amperometric biosensors in three important industries namely, the food, fermentation, and dairy industries, and highlights the potential use of these biosensors in various domains of these industries. These industries can employ the use of amperometric biosensors to control and monitor the presence of various metabolites and constituents that may either be of economic importance or toxic to the consumers. The continuous monitoring of these metabolites is of prime importance as they ultimately determine the quality of the end product. The review also gives a comprehensive description of the modifications done in the amperometric biosensors, using specific biomolecules and chemicals, along with their associated analytical features.

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Nanoparticles for Biosensors

Cited by 9 publications

References 128 publications

Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

Novel Approaches to Enzyme-Based Electrochemical Nanobiosensors

Amperometric Biosensors as an Analytical Tool in Food, Dairy and Fermentation Industries

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Nanoparticles for Biosensors

Cited by 9 publications

References 128 publications

Fabrication of α-Fe2O3 Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

Fabrication of α-Fe2O3 Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

Novel Approaches to Enzyme-Based Electrochemical Nanobiosensors

Amperometric Biosensors as an Analytical Tool in Food, Dairy and Fermentation Industries

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Product

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Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells