Nanoparticles for bioimaging

Sharma, Prashant; Brown, Scott C.; Walter, Glenn A.; Santra, Swadeshmukul; Moudgil, Brij M.

doi:10.1016/j.cis.2006.05.026

Cited by 673 publications

(460 citation statements)

References 242 publications

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“…LNPs display a number of features that make them interesting for in vivo imaging, such as tunable pharmacokinetics (blood half-life and clearance mode), resistance to photobleaching and large surface to volume ratios (so that multiple targeting groups and therapeutic agents can be conjugated to them). 15,16 A great variety of LNPs have been applied in biomedical research, not only for imaging but also for other purposes including drug delivery and in vitro and in vivo photothermal therapies. 17 Quantum dots (QDs), 18,19 gold NPs, 20 carbonbased NPs (C-NPs), 21,22 organic NPs, 23 and rare earth-doped nanocrystals (RENPs) 24 are among the nanoparticle-based fluorescent probes that have been successfully used in biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Rosal

Pérez‐Delgado

Misiak

et al. 2015

Journal of Applied Physics

107

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The spectroscopic properties of different infrared-emitting neodymium-doped nanoparticles (LaF 3 :Nd 3þ , SrF 2 :Nd 3þ , NaGdF 4 : Nd 3þ , NaYF 4 : Nd 3þ , KYF 4 : Nd 3þ , GdVO 4 : Nd 3þ , and Nd:YAG) have been systematically analyzed. A comparison of the spectral shapes of both emission and absorption spectra is presented, from which the relevant role played by the host matrix is evidenced. The lack of a "universal" optimum system for infrared bioimaging is discussed, as the specific bioimaging application and the experimental setup for infrared imaging determine the neodymiumdoped nanoparticle to be preferentially used in each case. V C 2015 AIP Publishing LLC.

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Section: Introductionmentioning

confidence: 99%

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Rosal

Pérez‐Delgado

Misiak

et al. 2015

Journal of Applied Physics

107

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“…Their carbonaceous nature, resonance Raman scattering, photoluminescence, strong near-infrared optical absorption, notable photothermal therapy properties, close structural resemblance with biomolecules and the possibility of tethering various functional groups on the surface of CNTs promote their application for multimodal therapy, as carrier for therapeutics, in diagnosis, for prosthesis delivery, and as a matrix for fabricating tissue regeneration scaffolds [2 -7]. Metal nanoparticles (NPs) or quantum dot-conjugated CNTs have been used as labelling, imaging and tracking agents [2,8,9]. Folic acid and nucleic acid aptamers are examples of targeting moieties studied for cancer therapy that can bind specifically to target cells [10,11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxicity, biophysics and biomechanics of cells treated with functionalized hybrid nanomaterials

Subbiah

Ramasundaram

et al. 2013

J. R. Soc. Interface.

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Hybrids consisting of carboxylated, single-walled carbon nanotube (c-SWNT)-silver nanoparticles (AgNPs)-DNA-poly vinyl alcohol (PVA) are synthesized via sequential functionalization to mimic the theragnostic (therapy and diagnosis) system. Carboxylation of SWNT has minimized the metal impurities with plenty of -COOH groups to produce hybrid (c-SWNT-AgNPs). The hybrid is further wrapped with DNA (hybrid-DNA) and encapsulated with PVA as hybrid composite (HC). Materials were tested against human alveolar epithelial cells (A549), mouse fibroblasts cells (NIH3T3) and human bone marrow stromal cells (HS-5). The composition-sensitive physico-chemical interactions, biophysics and biomechanics of materials-treated cells are evaluated. The cell viability was improved for HC, hybrid-PVA and c-SWNT when compared with SWNT and hybrid. SWNT and hybrid showed cell viability less than 60% at high dose (40 mg ml 21 ) and hybrid-PVA and HC retained 80% or more cell viability. The treatment of hybrid nanomaterials considerably changed cell morphology and intercellular interaction with respect to the composition of materials. Peculiarly, PVA-coated hybrid was found to minimize the growth of invadopodia of A549 cells, which is responsible for the proliferation of cancer cells. Surface roughness of cells increased after treatment with hybrid, where cytoplasmic regions specifically showed higher roughness. Nanoindentation results suggest that changes in biomechanics occurred owing to possible internalization of the hybrid. The changes in force spectra of treated cells indicated a possible greater interaction between the cells and hybrid with distinct stiffness and demonstrated the surface adherence and internalization of hybrid on or inside the cells.

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“…20 Nanoparticles can be coated with multiple ligands or probes and the consequent multivalent binding to target molecules could result in dramatically increased uptake and retention of the particles. Nanoparticles can be coated with a large number of such signal-generating molecules, thereby increasing the intensity of the imaging signal.…”

Section: Imaging Of Target Expressionmentioning

confidence: 99%

Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs

et al. 2008

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SUMMARYTargeted drugs hold great promise for the treatment of malignant tumors; however, there are several challenges for efficient evaluation of these drugs in preclinical and clinical studies. These challenges include identifying the 'correct', biologically active concentration and dose schedule, selecting the patients likely to benefit from treatment, monitoring inhibition of the target protein or pathway, and assessing the response of the tumor to therapy. Although anatomic imaging will remain important, molecular imaging provides several new opportunities to make the process of drug development more efficient. Various techniques for molecular imaging that enable noninvasive and quantitative imaging are now available in the preclinical and clinical settings, to aid development and evaluation of new drugs for the treatment of cancer. In this Review, we discuss the integration of molecular imaging into the process of drug development and how molecular imaging can address key questions in the preclinical and clinical evaluation of new targeted drugs. Examples include imaging of the expression and inhibition of drug targets, noninvasive tissue pharmacokinetics, and early assessment of the tumor response.

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Nanoparticles for bioimaging

Cited by 673 publications

References 242 publications

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Evaluation of cytotoxicity, biophysics and biomechanics of cells treated with functionalized hybrid nanomaterials

Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs

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