Nanoparticles Biosynthesized by Fungi and Yeast: A Review of Their Preparation, Properties, and Medical Applications

Moghaddam, Amin Boroumand; Namvar, Farideh; Moniri, Mona; Tahir, Paridah Md.; Azizi, Susan; Mohamad, Rosfarizan

doi:10.3390/molecules200916540

Cited by 341 publications

(70 citation statements)

References 142 publications

(116 reference statements)

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“…Although several reviews reported the importance of biogenically synthesized Ag°nanoparticles for several applications (Abbasi et al 2014;Faramarzi and Sadighi, 2013;de Lima et al 2012; , 2014aIngal and Chaudhari, 2013;Keat et al 2015;Mashwani et al 2015;Mittal et al 2014;Moghaddam et al 2015;Natsuki et al 2015;Rai et al 2009) to our best knowledge, this is the first review to critically discuss the common problems on the erroneous characterization of Ag°nanoparticles obtained by biogenic routes. This review does not intend to cover all the literature; however, the aim of this paper is to alert that there are many published papers with confusing characterization of biogenic synthesized Ag°nanoparticles and their antibacterial effects, and it aims to be an alert for new developments in this field.…”

Section: Introductionmentioning

confidence: 94%

“…Biogenic synthesis of Ag°nanoparticles is from a long time known for many researchers, and several excellent reviews were published in the last 6 years (Abbasi et al 2014;Faramarzi and Sadighi, 2013;de Lima et al 2012;Durán et al 2009Durán et al , 2010Durán et al , 2014aIngal and Chaudhari, 2013;Keat et al 2015;Mashwani et al 2015;Mittal et al 2014;Moghaddam et al 2015;Natsuki et al 2015;Rai et al 2009). Biogenic synthetic routes have several advantages over traditional chemical or physical ones, since they are environmentally friendly technology (Seabra and Durán, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial activity of biogenic silver nanoparticles, and silver chloride nanoparticles: an overview and comments

Durán

Nakazato

Seabra

2016

Appl Microbiol Biotechnol

223

117

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The antimicrobial impact of biogenic-synthesized silver-based nanoparticles has been the focus of increasing interest. As the antimicrobial activity of nanoparticles is highly dependent on their size and surface, the complete and adequate characterization of the nanoparticle is important. This review discusses the characterization and antimicrobial activity of biogenic synthesized silver nanoparticles and silver chloride nanoparticles. By revising the literature, there is confusion in the characterization of these two silver-based nanoparticles, which consequently affects the conclusion regarding to their antimicrobial activities. This review critically analyzes recent publications on the synthesis of biogenic silver nanoparticles and silver chloride nanoparticles by attempting to correlate the characterization of the nanoparticles with their antimicrobial activity. It was difficult to correlate the size of biogenic nanoparticles with their antimicrobial activity, since different techniques are employed for the characterization. Biogenic synthesized silver-based nanoparticles are not completely characterized, particularly the nature of capped proteins covering the nanomaterials. Moreover, the antimicrobial activity of theses nanoparticles is assayed by using different protocols and strains, which difficult the comparison among the published papers. It is important to select some bacteria as standards, by following international foundations (Pharmaceutical Microbiology Manual) and use the minimal inhibitory concentration by broth microdilution assays from Clinical and Laboratory Standards Institute, which is the most common assay used in antibiotic ones. Therefore, we conclude that to have relevant results on antimicrobial effects of biogenic silver-based nanoparticles, it is necessary to have a complete and adequate characterization of these nanostructures, followed by standard methodology in microbiology protocols.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of biogenic silver nanoparticles, and silver chloride nanoparticles: an overview and comments

Durán

Nakazato

Seabra

2016

Appl Microbiol Biotechnol

223

117

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“…Green strategies frequently employ either living organisms or natural extracts since these contain a plethora of biodegradable, generally nontoxic biomolecules that can serve both as reducing and stabilizing agents. 12,14,15 Plant extracts offer a large variety of antioxidants that could contribute to nanoparticle formation in various ways. 16 For instance, flavonoid-rich plant extracts proved to be excellent candidates for silver ion reduction, according to a variety of different publications.…”

Section: Introductionmentioning

confidence: 99%

<p>Silver nanoparticles: aggregation behavior in biorelevant conditions and its impact on biological activity</p>

Bélteky

Rónavári

Igaz

et al. 2019

IJN

138

109

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PurposeThe biomedical applications of silver nanoparticles (AgNPs) are heavily investigated due to their cytotoxic and antimicrobial properties. However, the scientific literature is lacking in data on the aggregation behavior of nanoparticles, especially regarding its impact on biological activity. Therefore, to assess the potential of AgNPs in therapeutic applications, two different AgNP samples were compared under biorelevant conditions.MethodsCitrate-capped nanosilver was produced by classical chemical reduction and stabilization with sodium citrate (AgNP@C), while green tea extract was used to produce silver nanoparticles in a green synthesis approach (AgNP@GTs). Particle size, morphology, and crystallinity were characterized using transmission electron microscopy. To observe the effects of the most important biorelevant conditions on AgNP colloidal stability, aggregation grade measurements were carried out using UV-Vis spectroscopy and dynamic light scatterig, while MTT assay and a microdilution method were performed to evaluate the effects of aggregation on cytotoxicity and antimicrobial activity in a time-dependent manner.ResultsThe aggregation behavior of AgNPs is mostly affected by pH and electrolyte concentration, while the presence of biomolecules can improve particle stability due to the biomolecular corona effect. We demonstrated that high aggregation grade in both AgNP samples attenuated their toxic effect toward living cells. However, AgNP@GT proved less prone to aggregation thus retained a degree of its toxicity.ConclusionTo our knowledge, this is the first systematic examination regarding AgNP aggregation behavior with simultaneous measurements of its effect on biological activity. We showed that nanoparticle behavior in complex systems can be estimated by simple compounds like sodium chloride and glutamine. Electrostatic stabilization might not be suitable for biomedical AgNP applications, while green synthesis approaches could offer new frontiers to preserve nanoparticle toxicity by enhancing colloidal stability. The importance of properly selected synthesis methods must be emphasized as they profoundly influence colloidal stability, and therefore biological activity.

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“…21, 22 Further development in this arena could exploit interactions of novel ENMs with bacterial EPS as well as inhibition of functional amyloids associated with bacterial genera such as certain E. coli and Pseudomonas strains. 276–279 In addition, with highly active research in green chemistry and biosynthesis of antibacterial ENMs using extracts and extracellular substances from various organisms, 280, 281 it is increasingly important to focus on the biocorona formed during NP synthesis to avoid introducing potentially cytotoxic biomolecules. This area is potentially rewarding scientifically, with far-reaching implications in medicine, food science, agriculture, wastewater treatment, and environmental remediation and engineering.…”

Section: Discussionmentioning

confidence: 99%

NanoEHS beyond toxicity – focusing on biocorona

Lin

Mortimer

Chen

et al. 2017

Environ. Sci.: Nano

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The first phase of environmental health and safety of nanomaterials (nanoEHS) studies has been mainly focused on evidence-based investigations that probe the impact of nanoparticles, nanomaterials and nano-enabled products on biological and ecological systems. The integration of multiple disciplines, including colloidal science, nanomaterial science, chemistry, toxicology/immunology and environmental science, is necessary to understand the implications of nanotechnology for both human health and the environment. While strides have been made in connecting the physicochemical properties of nanomaterials with their hazard potential in tiered models, fundamental understanding of nano-biomolecular interactions and their implications for nanoEHS is largely absent from the literature. Research on nano-biomolecular interactions within the context of natural systems not only provides important clues for deciphering nanotoxicity and nanoparticle-induced pathology, but also presents vast new opportunities for screening beneficial material properties and designing greener products from bottom up. This review highlights new opportunities concerning nano-biomolecular interactions beyond the scope of toxicity.

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Nanoparticles Biosynthesized by Fungi and Yeast: A Review of Their Preparation, Properties, and Medical Applications

Cited by 341 publications

References 142 publications

Antimicrobial activity of biogenic silver nanoparticles, and silver chloride nanoparticles: an overview and comments

Antimicrobial activity of biogenic silver nanoparticles, and silver chloride nanoparticles: an overview and comments

<p>Silver nanoparticles: aggregation behavior in biorelevant conditions and its impact on biological activity</p>

NanoEHS beyond toxicity – focusing on biocorona

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