Nanoparticles based on quantum dots and a luminol derivative: implications for in vivo imaging of hydrogen peroxide by chemiluminescence resonance energy transfer

Lee, Eun Sook; You, Dong Gil; Jeon, Jueun; Yi, Gi‐Ra; Lee, Jung Young; Lee, Sang Soo; Suh, Yung Doug; Park, Jae Hyung

doi:10.1039/c5cc09850e

Cited by 67 publications

(56 citation statements)

References 31 publications

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“…PEG−QDs containing a CdSeTe core coated with an amphiphilic polymer emitted at 800 nm. The designed CRET platform was used in CL imaging and in vivo detection of ROS through NIR light generation …”

Section: Semiconductor Quantum Dotsmentioning

confidence: 99%

Quantum dots‐based chemiluminescence probes: an overview

Song

Zhang

et al. 2019

Luminescence

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This mini-review describes the recent developments in quantum dots-based nanoprobes in liquid-phase chemiluminescence (CL) analysis. In the referenced reports, multiple quantum dots (QDs) were adopted as final emission species either after direct oxidation reactions (direct CL) or after chemiluminescence resonance energy transfer (indirect CL). This review does not include papers in which QDs have been used as enhancers, catalysts, carriers or quenchers in chemiluminescence systems. A brief overview on the CL mechanisms of various QDs-based nanoprobes and their analytical applications over the last decade is given, followed by comments on the future challenges and prospects in this field. KEYWORDS chemiluminescence (CL), nanoprobe, quantum dots (QDs)

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Section: Semiconductor Quantum Dotsmentioning

confidence: 99%

Quantum dots‐based chemiluminescence probes: an overview

Song

Zhang

et al. 2019

Luminescence

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“…However, owing to fast consumption of CL donor energy within the nanostructure (9), the optical signals of CRET-NPs disappear in a few minutes. This short duration of the CL signal produced by conventional CRET-NPs limits in vivo applications for diagnoses of intractable diseases, such as cancer and rheumatoid arthritis, and inflammatory disorders (5,6). To overcome such limitations of conventional CRET-NPs, we used a new approach by reinterpreting the hidden nature of CRET (Fig.…”

Section: Discussionmentioning

confidence: 99%

Chemiluminescence resonance energy transfer–based nanoparticles for quantum yield–enhanced cancer phototheranostics

Jeon

You

et al. 2020

Sci. Adv.

Self Cite

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Chemiluminescence (CL) has recently gained attention for CL resonance energy transfer (CRET)–mediated photodynamic therapy of cancer. However, the short duration of the CL signal and low quantum yield of the photosensitizer have limited its translational applications. Here, we report CRET-based nanoparticles (CRET-NPs) to achieve quantum yield–enhanced cancer phototheranostics by reinterpreting the hidden nature of CRET. Owing to reactive oxygen species (ROS)–responsive CO2 generation, CRET-NPs were capable of generating a strong and long-lasting photoacoustic signal in the tumor tissue via thermal expansion–induced vaporization. In addition, the CRET phenomenon of the NPs enhanced ROS quantum yield of photosensitizer through both electron transfer for an oxygen-independent type I photochemical reaction and self-illumination for an oxygen-dependent type II photochemical reaction. Consequently, owing to their high ROS quantum yield, CRET-NPs effectively inhibited tumor growth with complete tumor growth inhibition in 60% of cases, even with a single treatment.

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“…Alternatively, QDs with high quantum yield exhibit good stability against photobleaching. In order to reduce the cytotoxicity of QDs and increase their biocompatibility for in vivo imaging, polymer-covered and surface-modified QDs, poly(ethylene glycol)-QDs (PEG-QDs), were fabricated 88. To detect in vitro and in vivo H 2 O 2 , PEG and luminol derivative L012 were modified on the surface of QDs.…”

Section: In Vivo CL Imagingmentioning

confidence: 99%

Chemiluminescence and Bioluminescence Imaging for Biosensing and Therapy: In Vitro and In Vivo Perspectives

Yan

Shi

Song³

et al. 2019

Theranostics

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Chemiluminescence (CL) and bioluminescence (BL) imaging technologies, which require no external light source so as to avoid the photobleaching, background interference and autoluminescence, have become powerful tools in biochemical analysis and biomedical science with the development of advanced imaging equipment. CL imaging technology has been widely applied to high-throughput detection of a variety of analytes because of its high sensitivity, high efficiency and high signal-to-noise ratio (SNR). Using luciferase and fluorescent proteins as reporters, various BL imaging systems have been developed innovatively for real-time monitoring of diverse molecules in vivo based on the reaction between luciferin and the substrate. Meanwhile, the kinetics of protein interactions even in deep tissues has been studied by BL imaging. In this review, we summarize in vitro and in vivo applications of CL and BL imaging for biosensing and therapy. We first focus on in vitro CL imaging from the view of improving the sensitivity. Then, in vivo CL applications in cells and tissues based on different CL systems are demonstrated. Subsequently, the recent in vitro and in vivo applications of BL imaging are summarized. Finally, we provide the insight into the development trends and future perspectives of CL and BL imaging technologies.

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Nanoparticles based on quantum dots and a luminol derivative: implications for in vivo imaging of hydrogen peroxide by chemiluminescence resonance energy transfer

Cited by 67 publications

References 31 publications

Quantum dots‐based chemiluminescence probes: an overview

Quantum dots‐based chemiluminescence probes: an overview

Chemiluminescence resonance energy transfer–based nanoparticles for quantum yield–enhanced cancer phototheranostics

Chemiluminescence and Bioluminescence Imaging for Biosensing and Therapy: In Vitro and In Vivo Perspectives

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