Nanoparticles as labels of specific-recognition reactions for the determination of biomolecules by inductively coupled plasma-mass spectrometry

Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events

“…The signal-tonoise ratio drastically improves and the influence of spectral interference decreases, unless the interference occurs due to the presence of a parent element in the target nanostructures. 35 The work by Hu et al was followed by another article by some of the same authors comparing figures of merit for the determination of Au-labeled IgG using ICP-MS in both conventional and single particle mode. The latter offered an order of magnitude of improvement in terms of limit of detection, at the cost of a slightly worse performance in terms of precision and linear range.…”

Mass Spectrometric Biosensing: A Powerful Approach for Multiplexed Analysis of Clinical Biomolecules

“…With the development of nanoscience, researchers have paid more attention to nanomaterials serving as elemental tags . The large amount of metal atoms in nanoparticles (NPs), such as AuNPs, AgNPs, PtNPs, − quantum dots, upconversion NPs, and metal nanoclusters, make them excellent amplification tags for metal stable isotope tagging-based detection with enhanced sensitivity.…”

Immunoassays based on inductively coupled plasma mass spectrometry detection: So far so good, so what?

“…amino groups, etc.). A wide selection of element tags has been proposed in the literature but REE chelates [24,25] and inorganic NPs of different composition and size are, by far, the most employed [26]. The conjugation process between the element tag and the antibody mostly determines immunoassay figures of merit.…”

“…Au, Ag, etc.) [26] fulfil most of these requirements and, hence, they are widely employed as element tags for antibody conjugation. Though REE elements have been employed as NPs (e.g.…”