Nanoparticles as a novel and promising antiviral platform in veterinary medicine

Fawzy, Mohamed; Khairy, Gasser M.; Hesham, Ahmed; Rabaan, Ali A.; El-Shamy, Ahmed G.; Nagy, Abdou

doi:10.1007/s00705-021-05177-w

Cited by 13 publications

(11 citation statements)

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“…However, in the period studied, the new knowledge from universities and scientific instructions worldwide have not yet reached the vac-cine producer. Much research on natural, microbial, and nanotechnological adjuvants is left only for academic demonstrations (Fawzy et al, 2021); Heegaard et al, 2011). The results are still very far from benefiting the industry because the development of stable, reproducible, robust, scalable formulations that comply with good production practices remained in the background.…”

Section: Discussionmentioning

confidence: 99%

Technology surveillance in veterinary vaccine adjuvants (2015-2022): University-industry interaction

Odio¹,

Pérez²,

Batista-Duharte³

et al. 2022

J Pharm Pharmacogn Res

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Context: The new generation of immunoenhancers will have to offer solutions to each clinical and technological limitation that currently exists. This innovative context requires periodic technological surveillance by the veterinary biopharmaceutical industry to anticipate technological changes and predict future competitive advantages. Aims: To evaluate the current status, scientific trends, and technological projections in the use of veterinary immunological adjuvants for productive and companion species in the period 2015 and 2021. Methods: The bibliometric analysis included scientific articles on adjuvants in veterinary medicine published in English in 2015–2021 and indexed on the Scopus and Web of Science platforms. All relevant records retrieved between 2015 and 2022 were grouped using the EndNote bibliographic manager, while the analysis of the relational metric indicator was performed and viewed by VOSviewer®. Instead, data on the main commercial veterinary vaccine adjuvants in 2022 were collected from the official websites of 20 veterinary vaccine manufacturers with experience in the market. Results: The academy dedicated 68.2% of its production to disseminating articles with original experimental results with 73.6% being novel notifications about adjuvants of natural, microbial and nanotechnological origin. Industrial production mainly used monoadjuvation (86.9%), inorganic salts adjuvants (48.1%), particularly aluminum hydroxide (43.0%), and classical technology (89.2%) to produce their commercial formulations. Ruminants, swines, and poultry dominated both sectors, with ruminants being the main protagonist. Conclusions: The new scientific knowledge will not have a significant impact on the veterinary pharmaceutical industry in the short term and the hegemonic continuity of traditional adjuvants, in particular aluminum hydroxide, is expected.

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Section: Discussionmentioning

confidence: 99%

Technology surveillance in veterinary vaccine adjuvants (2015-2022): University-industry interaction

Odio¹,

Pérez²,

Batista-Duharte³

et al. 2022

J Pharm Pharmacogn Res

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“…A nanoparticle is defined as a particle with an average diameter between a nanometer and a hundred nanometers. Nano means "very small" since 1 nanometer (nm) is equivalent to 10 -9 meters (m) [44]. There are many unique properties of nanoparticles (NPs), which include their large surface-to-volume ratio, higher surface reactivity, stability, bioactivity, and bioavailability [43].…”

Section: Nanoparticles Application and Efficacy Of Nanoparticles Agai...mentioning

confidence: 99%

Nanoparticles in Feed: a Potential Approach for Mitigating Heat Stress on Broilers

Al‐Shuhaib

Ali

Ajafar

2022

RAS

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A major environmental stressor for the poultry industry is heat stress, which results in substantial economic losses. Heat stress has recently garnered increasing public awareness and concern for its adverse effects on poultry welfare. Several physiological changes happen under heat stress, including oxidative stress, acid-base imbalance, and immunosuppression, leading to increased mortality and decreased feed efficiency, body weight, feed intake, and egg production. Reduced nutrient intake is a significant contributor to the reduction in growth performance in heat-stressed animals, perhaps because they consume less feed to reduce heat production. Hence, heat stress can be attenuated in poultry using several different strategies, each with varying degrees of effectiveness. Nanotechnology strategies have gained more attention and are found to reduce heat stress's detrimental effects. Nanotechnology focuses on creating materials with nano-sized particles that have improved physical, chemical, and biological properties. Also, nanotechnology can be used in poultry production to improve the ability of birds to absorb nutrients and, in turn, increase growth performance, nutrient digestion, and productivity. Therefore, this review provides scientific evidence regarding the adverse effects of high ambient temperatures on poultry health and performance and potential nanoparticle approaches to mitigate those detrimental effects and their challenges.

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“…Nanotechnology-derived vaccine delivery systems have received a substantial amount of attention during the last two decades as viable alternatives to conventional veterinary vaccines, although most are in the early stages of development [ 15 , 16 ]. Nevertheless, the use of microparticles (MPs) or nanoparticles as vaccine adjuvant delivery vehicles for veterinary medicine remains largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

Physical, Chemical, and Biological Properties of Chitosan-Coated Alginate Microparticles Loaded with Porcine Interleukin-1β: A Potential Protein Adjuvant Delivery System

Chen

Lien

et al. 2022

IJMS

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We previously developed chicken interleukin-1β (IL-1β) mutants as single-dose adjuvants that induce protective immunity when co-administered with an avian vaccine. However, livestock such as pigs may require a vaccine adjuvant delivery system that provides long-lasting protection to reduce the need for successive booster doses. Therefore, we developed chitosan-coated alginate microparticles as a carrier for bovine serum albumin (BSA) or porcine IL-1β (pIL-1β) and assessed their physical, chemical, and biological properties. Electrospraying of the BSA-loaded alginate microparticles (BSA/ALG MPs) resulted in an encapsulation efficiency of 50%, and those MPs were then coated with chitosan (BSA/ALG/CHI MPs). Optical and scanning electron microscopy, zeta potential analysis, and Fourier transform infrared spectroscopy were used to characterize these MPs. The BSA encapsulation parameters were applied to ALG/CHI MPs loaded with pIL-1β, which were not cytotoxic to porcine fibroblasts but had enhanced bio-activity over unencapsulated pIL-1β. The chitosan layer of the BSA/ALG/CHI MPs prevented burst release and facilitated sustained release of pIL-1β for at least 28 days. In conclusion, BSA/ALG/CHI MPs prepared as a carrier for pIL-1β may be used as an adjuvant for the formulation of pig vaccines.

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Nanoparticles as a novel and promising antiviral platform in veterinary medicine

Cited by 13 publications

References 100 publications

Technology surveillance in veterinary vaccine adjuvants (2015-2022): University-industry interaction

Technology surveillance in veterinary vaccine adjuvants (2015-2022): University-industry interaction

Nanoparticles in Feed: a Potential Approach for Mitigating Heat Stress on Broilers

Physical, Chemical, and Biological Properties of Chitosan-Coated Alginate Microparticles Loaded with Porcine Interleukin-1β: A Potential Protein Adjuvant Delivery System

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