Nanoparticles and their applications in cell and molecular biology

Wang, Edina C.; Wang, Andrew Z.

doi:10.1039/c3ib40165k

Cited by 345 publications

(148 citation statements)

References 168 publications

(228 reference statements)

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“…The application of nanoscale materials and structures, usually ranging from 1 to 100 nm, has become an emerging area in the field of nanoscience and nanotechnology since from the past few decades (Wang and Wang 2014). Nanoparticles exhibit completely new or improved properties based on specific characteristics such as size, distribution and morphology.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted green synthesis of silver nanoparticles from Fraxinus excelsior leaf extract and its antioxidant assay

et al. 2015

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The biosynthesis of nanoparticles has been proposed as a cost effective and environmentally benevolent alternative to chemical and physical methods. In the present study, microwave assisted synthesis of silver nanoparticles (AgNPs) has been demonstrated using leaf extract of Fraxinus excelsior reducing aqueous AgNO 3 solution. The synthesized nanoparticles have been characterized on the basis of fourier transform infrared spectroscopy (FT-IR), UV-Vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy dispersive X-ray (EDX) analysis. The presence of a characteristic surface plasmon resonance (SPR) absorption band at 425 nm in UV-Vis reveals the reduction of silver metal ions into silver nanoparticles. FT-IR analysis was carried out to probe the possible functional group involved in the synthesis of AgNPs. Further leaf extracts and AgNPs were evaluated for antiradical scavenging activity by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay.

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Section: Introductionmentioning

confidence: 99%

Microwave-assisted green synthesis of silver nanoparticles from Fraxinus excelsior leaf extract and its antioxidant assay

et al. 2015

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“…6 A better understanding of the interactions between magnetic NPs and membranes can be achieved by assessment of their biocompatibility when used as potential diagnostic and therapeutic agents. 7,8 When NPs are administered intravenously, they interact with both target and nontarget cells, resulting in systemic effects including blood coagulation and changes in membrane permeability. 9 It has been proposed 10 that one of the first contacts between NPs and cells occurs at the cell membrane, where the NPs interact physically with the lipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Drašler¹,

Drobne²,

Novak³

et al. 2014

IJN

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Background The purpose of this work is to provide experimental evidence on the interactions of suspended nanoparticles with artificial or biological membranes and to assess the possibility of suspended nanoparticles interacting with the lipid component of biological membranes. Methods 1-Palmitoyl-2-oleoyl- sn -glycero-3-phosphocholine (POPC) lipid vesicles and human red blood cells were incubated in suspensions of magnetic bare cobalt ferrite (CoFe 2 O 4 ) or citric acid (CA)-adsorbed CoFe 2 O 4 nanoparticles dispersed in phosphate-buffered saline and glucose solution. The stability of POPC giant unilamellar vesicles after incubation in the tested nanoparticle suspensions was assessed by phase-contrast light microscopy and analyzed with computer-aided imaging. Structural changes in the POPC multilamellar vesicles were assessed by small angle X-ray scattering, and the shape transformation of red blood cells after incubation in tested suspensions of nanoparticles was observed using scanning electron microscopy and sedimentation, agglutination, and hemolysis assays. Results Artificial lipid membranes were disturbed more by CA-adsorbed CoFe 2 O 4 nanoparticle suspensions than by bare CoFe 2 O 4 nanoparticle suspensions. CA-adsorbed CoFe 2 O 4 -CA nanoparticles caused more significant shape transformation in red blood cells than bare CoFe 2 O 4 nanoparticles. Conclusion Consistent with their smaller sized agglomerates, CA-adsorbed CoFe 2 O 4 nanoparticles demonstrate more pronounced effects on artificial and biological membranes. Larger agglomerates of nanoparticles were confirmed to be reactive against lipid membranes and thus not acceptable for use with red blood cells. This finding is significant with respect to the efficient and safe application of nanoparticles as medicinal agents.

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“…The structure of low-generation dendrimers is usually flexible and open, whereas dendrimers of higher generations are dense and globular (26). Because of their unique design, dendrimers can be developed as sensors as well as drug and gene delivery carriers (27). The ability to tailor dendrimer properties to therapeutic needs makes them well suited as carriers for small-molecule drugs and biomolecules (28).…”

Section: Dendrimericmentioning

confidence: 99%

Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles

2016

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Over the last 2 decades, the use of nanoparticle imaging has been investigated extensively for both diagnosis and therapy of prostate cancer. This review discusses the various classes of nanoparticles currently in clinical use or at the advanced preclinical stage. In particular, we focus on the unique properties of nanoparticles, as a group, that make them suitable for imaging and therapy. The characteristics of each nanoparticle are detailed. Iron oxide nanoparticles, extensively used for MRI of prostate cancer, are discussed in depth.

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Nanoparticles and their applications in cell and molecular biology

Cited by 345 publications

References 168 publications

Microwave-assisted green synthesis of silver nanoparticles from Fraxinus excelsior leaf extract and its antioxidant assay

Microwave-assisted green synthesis of silver nanoparticles from Fraxinus excelsior leaf extract and its antioxidant assay

Effects of magnetic cobalt ferrite nanoparticles on biological and artificial lipid membranes

Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles

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