Nanoparticles and their antimicrobial properties against pathogens including bacteria, fungi, parasites and viruses

Khezerlou, Arezou; Sani, Mahmood Alizadeh; Azizi‐Lalabadi, Maryam; Ehsani, Ali

doi:10.1016/j.micpath.2018.08.008

Cited by 287 publications

(170 citation statements)

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“…Research on the synthesis of nanoparticles of binary inorganic compounds is chiefly important due to the countless possibilities of their application. Zinc oxide nanoparticles, the study of which has been described in this work, can be successfully utilized as vulcanization activators in the rubber industry, UV filters in sunscreen products, antibacterial agents in dermatological drugs, anode materials in lithium‐ion batteries, coating materials for orthopaedic and dental implants, or as catalysts in water purification from multiple pollutions (e.g. from potentially carcinogenic and mutagenic substances like methylene blue) …”

Section: Introductionmentioning

confidence: 99%

Structurally diverse coordination compounds of zinc as effective precursors of zinc oxide nanoparticles with various morphologies

Świątkowski

Kruszyński

2019

Applied Organom Chemis

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The structurally diverse coordination compounds of zinc were designed and synthesized using two types of building blocks: short‐chain carboxylate ions and hexamethylenetetraamine. They were characterized by X‐ray crystallography, infrared spectroscopy and thermal analysis. The studied compounds were used as precursors for production (via controlled thermal conversion) of zinc oxide nanoparticles. The conversion process was optimized in terms of two parameters (heating rate and maximum temperature). Such an approach, combined with proper design of the precursor structure, allows fabrication of various zinc oxide micro‐ and nanoparticles. The influence of a precursor structure and modifications of conversion parameters on size and morphology of ZnO particles were studied and discussed.

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Section: Introductionmentioning

confidence: 99%

Structurally diverse coordination compounds of zinc as effective precursors of zinc oxide nanoparticles with various morphologies

Świątkowski

Kruszyński

2019

Applied Organom Chemis

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“…As regards the use of antifungal agents, these can lead to the development of resistance in some fungal strains (Caniça et al 2019; Chechi et al 2019). AgNPs do not exert selective pressure on microorganisms and, therefore, do not lead to resistance (Lemire et al 2013; Khezerlou et al 2018); thus, these may be less toxic than synthetic fungicides.…”

Section: Discussionmentioning

confidence: 99%

“…AgNPs that manage to penetrate inside the cell cause an increase of Ag+ cations, which could affect the electrical potential of the membrane. According to Srikar et al (2016) and Khezerlou et al (2018), these Ag+ ions denaturate proteins, deplete intracellular ATP, and form complexes with DNA bases, so that the DNA loses its replication ability. On the other hand, the reaction of Ag + with thiol, carboxylate, phosphate, hydroxyl, amine, imidazole, and indole groups in enzymes may lead to their inactivation and cell death (Lin et al 1998; Ashraf et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…These have been used as antimicrobial agents for the in-vitro culture of various plant species (Spinoso-Castillo et al 2017; Tung et al 2018). The mechanisms of action of AgNPs as antifungal agent have not been fully elucidated because most studies have addressed antiviral and antibacterial properties (Pařil et al 2017; Khezerlou et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Antifungal activity of silver nanoparticles during in-vitro culture of Stevia rebaudiana Bertoni

Sánchez-Segura

et al. 2019

Preprint

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30Contamination by fungi and bacteria during the in-vitro propagation of plants leads to considerable losses of biological 31 material and precludes phytosanitary certification. The anti-microbial effect of silver nanoparticles (AgNPs) may be 32 an alternative for the eradication of in-vitro contaminants. This study evaluated the microbicidal activity of AgNPs on 33 a recurrent fungus during the micropropagation of stevia (Stevia rebaudiana Bertoni). First, the fungus was isolated 34 and identified at a molecular level by the sequencing and analysis of the ITS4/ITS5 rDNA region. The results of the 35 phylogenetic analysis of various fungi species showed that the strain under study (16-166-H) belongs to the genus 36 Sordaria and is 86.74% similar to S. tomento-alba (strain CBS 260.78). Subsequently, the inhibition of the growth of 37 S. tomento-alba was tested under different concentrations of AgNPs (0, 25, 50, 100, and 200 mg L -1 ), observing that 38 50 and 100 mg L -1 achieve ca. 50% growth inhibition (IC 50 ), while 200 mg L -1 produces a drastic inhibition. On the 39 other hand, the shape and size of AgNPs was examined using transmission electron microscopy (TEM), and the 40 transport and accumulation of AgNPs in S. tomento-alba cells were monitored through multiphoton microscopy. The 41 morphological and fluorescence analyses showed that AgNPs display different sizes, with larger nanoparticles retained 42 in fungal cell walls while smaller AgNPs penetrate into fungal cells. Probably, apoplastic and symplastic mechanisms 43 involved in the accumulation and transport of AgNPs affect the metabolic processes of the fungus, thus inhibiting its 44 growth. These results suggest that AgNPs possess antifungal activity and can be used in the eradication of contaminants 45 during the in-vitro culture of plant species.46 47

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“…Moreover, Ag-NPs prevent the biofilm formation of L. monocytogenes in humid conditions of growth at concentrations of 500 ppm. Additional studies under different conditions are needed to test the durability of nanoparticle containing polyester surfaces with antimicrobial properties to optimize their use.Foods 2020, 9, 442 2 of 15 studies include the development of antimicrobial surfaces capable of preventing and/or inhibiting bacterial adhesion [8][9][10][11].Metal agents such as silver, copper, zinc, titanium, and cobalt have antimicrobial properties. When these agents remain on surfaces, their biocidal properties are gradually released onto the surface through a process of ion exchange, providing continuous, lasting antimicrobial activity [12][13][14].…”

mentioning

confidence: 99%

Antimicrobial Activity and Prevention of Bacterial Biofilm Formation of Silver and Zinc Oxide Nanoparticle-Containing Polyester Surfaces at Various Concentrations for Use

Fontecha‐Umaña

Ríos-Castillo

Ripolles‐Avila

et al. 2020

Foods

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Food contact surfaces are primary sources of bacterial contamination in food industry processes. With the objective of preventing bacterial adhesion and biofilm formation on surfaces, this study evaluated the antimicrobial activity of silver (Ag-NPs) and zinc oxide (ZnO-NPs) nanoparticle-containing polyester surfaces (concentration range from 400 ppm to 850 ppm) using two kinds of bacteria, Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli), and the prevention of bacterial biofilm formation using the pathogen Listeria monocytogenes. The results of antimicrobial efficacy (reductions ≥ 2 log CFU/cm 2 ) showed that at a concentration of 850 ppm, ZnO-NPs were effective against only E. coli (2.07 log CFU/cm 2 ). However, a concentration of 400 ppm of Ag-NPs was effective against E. coli (4.90 log CFU/cm 2 ) and S. aureus (3.84 log CFU/cm 2 ). Furthermore, a combined concentration of 850 ppm Ag-NPs and 400 ppm ZnO-NPs showed high antimicrobial efficacy against E. coli (5.80 log CFU/cm 2 ) and S. aureus (4.11 log CFU/cm 2 ). The results also showed a high correlation between concentration levels and the bacterial activity of Ag-ZnO-NPs (R 2 = 0.97 for S. aureus, and R 2 = 0.99 for E. coli). They also showed that unlike individual action, the joint action of Ag-NPs and ZnO-NPs has high antimicrobial efficacy for both types of microorganisms. Moreover, Ag-NPs prevent the biofilm formation of L. monocytogenes in humid conditions of growth at concentrations of 500 ppm. Additional studies under different conditions are needed to test the durability of nanoparticle containing polyester surfaces with antimicrobial properties to optimize their use.Foods 2020, 9, 442 2 of 15 studies include the development of antimicrobial surfaces capable of preventing and/or inhibiting bacterial adhesion [8][9][10][11].Metal agents such as silver, copper, zinc, titanium, and cobalt have antimicrobial properties. When these agents remain on surfaces, their biocidal properties are gradually released onto the surface through a process of ion exchange, providing continuous, lasting antimicrobial activity [12][13][14]. The biocidal properties of metal agents depend on the characteristics of their nanoparticles, such as size, distribution, morphology, and the release of very small quantities of their cations on the substrates on which they are acting [15,16]. The antimicrobial activity of these agents is also affected by extrinsic factors, such as the pH of the medium, time of exposure, concentration, UV radiation, and the presence of other substances or microorganisms [17][18][19].Two of the most extended nanocomposites for antibacterial purposes are silver and zinc oxides embedded in polymeric matrices [20][21][22]. The antimicrobial activity of silver (Ag) and zinc (Zn) repels or inhibits the initial attachment of bacteria by either exhibiting an anti-biofouling effect or by inactivating cells in contact with surfaces, causing their death [23,24]. Additionally, the antibacterial properties of these agents reduce the risk o...

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Nanoparticles and their antimicrobial properties against pathogens including bacteria, fungi, parasites and viruses

Cited by 287 publications

References 292 publications

Structurally diverse coordination compounds of zinc as effective precursors of zinc oxide nanoparticles with various morphologies

Structurally diverse coordination compounds of zinc as effective precursors of zinc oxide nanoparticles with various morphologies

Antifungal activity of silver nanoparticles during in-vitro culture of Stevia rebaudiana Bertoni

Antimicrobial Activity and Prevention of Bacterial Biofilm Formation of Silver and Zinc Oxide Nanoparticle-Containing Polyester Surfaces at Various Concentrations for Use

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