Nanoparticles and mesenchymal stem cells: a win-win alliance for anticancer drug delivery

Li, Min; Zhang, Fangrong; Chen, Kerong; Wang, Cheng; Su, Yujie; Liu, Yuan; Zhou, Jianping; Wang, Wei

doi:10.1039/c6ra00398b

Cited by 12 publications

(6 citation statements)

References 124 publications

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“…According to the literature, a pathway, involving CXCR4 and its ligand stromal-derived factor-1 (SDF-1), is the main axis in MSCs and cancer cell cross-talk and stem cell mobilization to tumors . Yet, ex vivo- cultivated MSCs tend to lose the marker due to changes in the microenvironment and the shift from 3D to 2D space, which is confirmed by our results of low CXCR4 expression (Figure B). Nevertheless, there are multiple other pathways responsible for MSC migration, including but not limited to the vascular endothelial growth factor, platelet-derived growth factor and their respective receptors, monocyte chemoattractant protein-1 (MCP-1) paired with the C–C chemokine receptor type 2 (CCR2) and cellular adhesion molecules, and other signaling pathways …”

Section: Resultsmentioning

confidence: 99%

Hitchhiking Nanoparticles: Mesenchymal Stem Cell-Mediated Delivery of Theranostic Nanoparticles

Dapkutė

Pleckaitis

Bulotienė

et al. 2021

ACS Appl. Mater. Interfaces

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Nanotechnology has emerged as a promising solution to permanent elimination of cancer. However, nanoparticles themselves lack specificity to tumors. Due to enhanced migration to tumors, mesenchymal stem cells (MSCs) were suggested as cell-mediated delivery vehicles of nanoparticles. In this study, we have constructed a complex composed of photoluminescent quantum dots (QDs) and a photosensitizer chlorin e6 (Ce6) to obtain multifunctional nanoparticles, combining cancer diagnostic and therapeutic properties. QDs serve as energy donorsexcited QDs transfer energy to the attached Ce6 via Forster resonance energy transfer, which in turn generates reactive oxygen species. Here, the physicochemical properties of the QD-Ce6 complex and singlet oxygen generation were measured, and the stability in protein-rich media was evaluated, showing that the complex remains the most stable in proteinfree medium. In vitro studies on MSC and cancer cell response to the QD-Ce6 complex revealed the complex-loaded MSCs' potential to transport theranostic nanoparticles and induce cancer cell death. In vivo studies proved the therapeutic efficacy, as the survival of tumor-bearing mice was statistically significantly increased, while tumor progression and metastases were slowed down.

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Section: Resultsmentioning

confidence: 99%

Hitchhiking Nanoparticles: Mesenchymal Stem Cell-Mediated Delivery of Theranostic Nanoparticles

Dapkutė

Pleckaitis

Bulotienė

et al. 2021

ACS Appl. Mater. Interfaces

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“…UMSCs have been reported to possess tumor-homing activity [37][38][39] . The CXCR4 and CCR2 expressed on UMSCs can interact with overexpressed SDF-1α and MCP-1 in GBM [40][41][42] , thus providing tumorhoming tropism 38,43,44 . Moreover, after activation by SDF-1α, VLA-4 on the surface of UMSCs can interact with VCAM-1 adhesion molecules and β1 integrin on endothelial cells of the BBB and aid penetration of the barrier by rolling and migration to achieve intracranial Gd agent delivery [45][46][47] .…”

Section: Gbm Homing Features Of Snsmentioning

confidence: 99%

Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy

Lai

Cheng

et al. 2023

Nat Commun

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The potential clinical application of gadolinium-neutron capture therapy (Gd-NCT) for glioblastoma multiforme (GBM) treatment has been compromised by the fast clearance and nonspecific biodistribution of gadolinium-based agents. We have developed a stem cell–nanoparticle system (SNS) to actively target GBM for advanced Gd-NCT by magnetizing umbilical cord mesenchymal stem cells (UMSCs) using gadodiamide-concealed magnetic nanoparticles (Gd-FPFNP). Nanoformulated gadodiamide shielded by a dense surface composed of fucoidan and polyvinyl alcohol demonstrates enhanced cellular association and biocompatibility in UMSCs. The SNS preserves the ability of UMSCs to actively penetrate the blood brain barrier and home to GBM and, when magnetically navigates by an external magnetic field, an 8-fold increase in tumor-to-blood ratio is achieved compared with clinical data. In an orthotopic GBM-bearing rat model, using a single dose of irradiation and an ultra-low gadolinium dose (200 μg kg−1), SNS significantly attenuates GBM progression without inducing safety issues, prolonging median survival 2.5-fold compared to free gadodiamide. The SNS is a cell-based delivery system that integrates the strengths of cell therapy and nanotechnology, which provides an alternative strategy for the treatment of brain diseases.

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“…Another MSCs drug delivery strategy is to combine them with nanoparticles (NP). Nanoparticles are used to introduce genetic modification in MSCs by replacing viral vectors, stimulating their proliferation and migration, and what is more, protecting them against the cytotoxic effects of the drugs carried, or controlled drug release [20]. Mathilde et al studied MSCs as carriers of NPs in brain tumours.…”

Section: Msc-based Drug Delivery Strategiesmentioning

confidence: 99%

MSCs and CAFs interactions in the prostate and bladder cancer microenvironment as the potential cause of tumour progression

Balik

Kaźmierski

Maj

et al. 2023

Medical Research Journal

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The tumour microenvironment (TME) is the broadly understood environment around the tumour.Cancer-associated fibroblasts (CAFs), Mesenchymal Stromal Cells (MSCs), and molecules synthesized by them are part of it. Both CAFs and MSCs can promote tumour progression by induction of an immunosuppressive, pro-inflammatory environment. Through indirect and direct cell-to-cell interactions they also have a pro-proliferative, pro-angiogenic, and pro-invasive effect on cancer cells.They can lead to aggressive cancer formation. At this stage, it is important to conduct research to modulate TME towards inhibition of cancer progression and preventing resistance to already introduced drugs. Moreover, it is extremely important to study these interactions in light of using MSCs in a drug-delivery strategy.

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Nanoparticles and mesenchymal stem cells: a win-win alliance for anticancer drug delivery

Abstract: Schematic illustration of the combination of NPs and MSCs drug delivery systems for cancer therapy.

Cited by 12 publications

References 124 publications

Hitchhiking Nanoparticles: Mesenchymal Stem Cell-Mediated Delivery of Theranostic Nanoparticles

Hitchhiking Nanoparticles: Mesenchymal Stem Cell-Mediated Delivery of Theranostic Nanoparticles

Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy

MSCs and CAFs interactions in the prostate and bladder cancer microenvironment as the potential cause of tumour progression

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