Nanoparticles and Liposomes for the Surface Modification of Implants: A Comparative Study of Spraying and Dipping Techniques

Abstract

Polysiloxane and polyurethane are one of the most commonly employed synthetic polymers for medical devices. Both materials are inexpensive and can be modified easily. The layer-by-layer technique is a well-documented method for surface modification. There are only two ways to modify large surface areas i.e. dipping and spraying. Both methods can be used to create anti-adhesive, antibacterial and anti-inflammatory layers. Particle density on the surface is an important parameter for preventing biofilm formation, bacterial adhesion and release of active agents. There should be an optimal number of particles covering the coated surface due to its direct correlation with the release of active agent (per time) and contact area with bacteria. Preliminary studies using regular dipping technique of layer-by-layer method have not produced substantial particle densities. Therefore, spraying method is employed using an atomiser to produce a fine mist containing norfloxacinloaded nanoparticles and liposomes. An optimal density of particles on the implant surface together with a homogeneous distribution is achieved using this method.

Biological Effects, Applications and Design Strategies of Medical Polyurethanes Modified by Nanomaterials

“…162 In LBL assembly, electrostatic interactions are used to drive the sequential adsorption of oppositely charged materials onto a PU substrate, resulting in a multilayer nanoscale coating. 27,163 These coatings have controllable thickness,…”

“…In LBL assembly, electrostatic interactions are used to drive the sequential adsorption of oppositely charged materials onto a PU substrate, resulting in a multilayer nanoscale coating. 27 , 163 These coatings have controllable thickness, predictable physicochemical properties, and bioefficacy (eg antibacterial and anticoagulative properties) and are used primarily for cardiovascular system which multiple properties are needed. 164–166 …”